Representation of Major Biochemical Pathway categories by the genes in PCMdb


A list of genes in PCMdb that can be classified as "Signal Transducers" by the UniProt database has been provided below.
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Gene Symbol Gene Name # of Entries
HTR1B5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled1
HTR1E5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled10
HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled10
HTR3B5-hydroxytryptamine (serotonin) receptor 3B, ionotropic20
HTR45-hydroxytryptamine (serotonin) receptor 4, G protein-coupled20
HTR5A5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled20
HTR65-hydroxytryptamine (serotonin) receptor 6, G protein-coupled21
HTR75-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled20
ADORA3adenosine A3 receptor9
ABCA17PATP-binding cassette, sub-family A (ABC1), member 11
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 81
CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal)20
CHRNA4cholinergic receptor, nicotinic, alpha 4 (neuronal)21
CHRNB2cholinergic receptor, nicotinic, beta 2 (neuronal)1
CHRNEcholinergic receptor, nicotinic, epsilon (muscle)10
CHRM1cholinergic receptor, muscarinic 19
CHRM2cholinergic receptor, muscarinic 210
ACVR1Cactivin A receptor, type IC1
ACVRL1activin A receptor type II-like 11
ADRA1Aadrenoceptor alpha 1A31
ADRA1Badrenoceptor alpha 1B1
ADRA1Dadrenoceptor alpha 1D20
ADRA2Aadrenoceptor alpha 2A10
ADRA2Badrenoceptor alpha 2B30
ADRA2Cadrenoceptor alpha 2C10
ADRB1adrenoceptor beta 120
ADRB3adrenoceptor beta 351
AGTR1angiotensin II receptor, type 110
AHRRaryl-hydrocarbon receptor repressor10
ALKBH4anaplastic lymphoma receptor tyrosine kinase1
PRMT2protein arginine methyltransferase 21
NPR2natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)20
NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)30
ANTXR1anthrax toxin receptor 11
ARAFv-raf murine sarcoma 3611 viral oncogene homolog10
ARNTLaryl hydrocarbon receptor nuclear translocator1
ACVR2Bactivin A receptor, type IIB13
BAI1brain-specific angiogenesis inhibitor 111
BAI2brain-specific angiogenesis inhibitor 29
BCAR1breast cancer anti-estrogen resistance 120
BDKRB1bradykinin receptor B120
ARNTaryl hydrocarbon receptor nuclear translocator-like10
CALCRcalcitonin receptor20
CBLBCbl proto-oncogene, E3 ubiquitin protein ligase B1
CBLCCbl proto-oncogene, E3 ubiquitin protein ligase C40
CREBBPCREB binding protein13
CCKcholecystokinin A receptor74
CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)13
CCR9chemokine (C-C motif) receptor 920
CD79ACD79a molecule, immunoglobulin-associated alpha20
CD79BCD79b molecule, immunoglobulin-associated beta1
CD8ACD8a molecule30
PCTK3cyclin-dependent kinase 189
CELSR1cadherin, EGF LAG seven-pass G-type receptor 110
CELSR3cadherin, EGF LAG seven-pass G-type receptor 331
CLEC1AC-type lectin domain family 1, member A20
CLDN3claudin 320
CLDN4claudin 413
CLTCL1clathrin, heavy chain-like 121
CNTFRciliary neurotrophic factor receptor2
COLEC12collectin sub-family member 1230
NR2F1nuclear receptor subfamily 2, group F, member 110
NR2F2nuclear receptor subfamily 2, group F, member 210
CR1complement component (3b/4b) receptor 1 (Knops blood group)97
CRHR1corticotropin releasing hormone receptor 19
CRHR2corticotropin releasing hormone receptor 241
CSF1Rcolony stimulating factor 1 receptor13
SLC44A2solute carrier family 44, member 29
IL8RBchemokine (C-X-C motif) receptor 220
CXCR3chemokine (C-X-C motif) receptor 31
CXCR4chemokine (C-X-C motif) receptor 48
DCCdeleted in colorectal carcinoma192
DCLK1doublecortin-like kinase 110
DCAMKL1doublecortin-like kinase 11
DDR1discoidin domain receptor tyrosine kinase 120
DKK1dickkopf WNT signaling pathway inhibitor 16
HLA-DQB1major histocompatibility complex, class II, DQ beta 11
DRD1dopamine receptor D150
DRD2dopamine receptor D231
DRD4dopamine receptor D421
DRD5dopamine receptor D520
EDNRBendothelin receptor type B100
EEF1Deukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)1
EFNA4ephrin-A49
EFNB3ephrin-B340
ELOVL4ELOVL fatty acid elongase 441
EMR3egf-like module containing, mucin-like, hormone receptor-like 313
EPHA2EPH receptor A21
EPHA4EPH receptor A41
EPHA5EPH receptor A563
EPHA8EPH receptor A820
EPHA10EPH receptor A1041
EPHB4EPH receptor B413
EPORerythropoietin receptor9
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)49
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)52
ESRRBestrogen-related receptor beta10
ESR1estrogen receptor 1109
GPR37G protein-coupled receptor 37 like 129
EFEMP1EGF containing fibulin-like extracellular matrix protein 140
FGFR1fibroblast growth factor receptor 114
FGFR2fibroblast growth factor receptor 214
FGFR3fibroblast growth factor receptor 31
FGFR4fibroblast growth factor receptor 413
FGFRL1fibroblast growth factor receptor-like 19
FLNAfilamin A, alpha10
FLRT2fibronectin leucine rich transmembrane protein 230
FLT3fms-related tyrosine kinase 342
FZD1frizzled family receptor 1041
FZD10frizzled family receptor 131
FZD2frizzled family receptor 210
FZD5frizzled family receptor 51
FZD7frizzled family receptor 710
FZD8frizzled family receptor 89
FZD9frizzled family receptor 943
GABBR2gamma-aminobutyric acid (GABA) B receptor, 220
GALR1galanin receptor 1124
GALR2galanin receptor 230
CCKARcholecystokinin B receptor13
GNB4guanine nucleotide binding protein (G protein), beta polypeptide 420
GNG4guanine nucleotide binding protein (G protein), gamma 41
GNG8guanine nucleotide binding protein (G protein), gamma 820
GNGT2guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 220
GABRA5gamma-aminobutyric acid (GABA) A receptor, alpha 511
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 110
GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 220
GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 311
GABRDgamma-aminobutyric acid (GABA) A receptor, delta1
GABREgamma-aminobutyric acid (GABA) A receptor, epsilon1
GFRA1GDNF family receptor alpha 151
GFRA3GDNF family receptor alpha 320
GFRA4GDNF family receptor alpha 420
GHRHRgrowth hormone releasing hormone receptor20
GHSRgrowth hormone secretagogue receptor30
GIPRgastric inhibitory polypeptide receptor9
GLP1Rglucagon-like peptide 1 receptor20
GNA11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)11
GNA14guanine nucleotide binding protein (G protein), alpha 141
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 29
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O29
GNAT1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 110
GPR12G protein-coupled receptor 12351
GPR123G protein-coupled receptor 12410
GPR133G protein-coupled receptor 1331
GPR135G protein-coupled receptor 1359
GPR143G protein-coupled receptor 14310
GPR153G protein-coupled receptor 15310
GPR158G protein-coupled receptor 15810
GPR124G protein-coupled receptor 1220
GPR20G protein-coupled receptor 201
GPR25G protein-coupled receptor 2530
GPR26G protein-coupled receptor 2640
GPR27G protein-coupled receptor 271
GPR35G protein-coupled receptor 3521
GPR37L1G protein-coupled receptor 37 (endothelin receptor type B-like)20
GPR39G protein-coupled receptor 3921
GPR42G protein-coupled receptor 42 (gene/pseudogene)20
GPR45G protein-coupled receptor 451
GPR55G protein-coupled receptor 5520
GPR56G protein-coupled receptor 5640
GPR6G protein-coupled receptor 6290
GPR62G protein-coupled receptor 6320
GPR63G protein-coupled receptor 6420
GPR64G protein-coupled receptor 610
GPR78G protein-coupled receptor 7840
GPR83G protein-coupled receptor 8340
GPR84G protein-coupled receptor 8420
GPR88G protein-coupled receptor 8822
GPR97G protein-coupled receptor 971
GRIA2glutamate receptor, ionotropic, AMPA 240
GRIA4glutamate receptor, ionotropic, AMPA 420
GRID1glutamate receptor, ionotropic, delta 111
GRID2glutamate receptor, ionotropic, delta 220
GRIK1glutamate receptor, ionotropic, kainate 130
GRIK2glutamate receptor, ionotropic, kainate 220
GRIK3glutamate receptor, ionotropic, kainate 351
GRIK5glutamate receptor, ionotropic, kainate 51
GRM1glutamate receptor, metabotropic 120
GRM2glutamate receptor, metabotropic 21
GRM6glutamate receptor, metabotropic 610
GRM8glutamate receptor, metabotropic 810
GRPRgastrin-releasing peptide receptor13
GPR109Ahydroxycarboxylic acid receptor 220
HNF4Ahepatocyte nuclear factor 4, alpha20
HRH2histamine receptor H21
HRH3histamine receptor H320
IL12RB2interleukin 12 receptor, beta 240
IL13RA1interleukin 13 receptor, alpha 11
IL17RAinterleukin 17 receptor A1
IGF1Rinsulin-like growth factor 1 receptor10
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)13
IL2interleukin 21 receptor52
IL1RL2interleukin 1 receptor-like 240
INSRRinsulin receptor-related receptor10
INSRinsulin receptor11
IRAK1interleukin-1 receptor-associated kinase 19
IRS1insulin receptor substrate 11
IRS2insulin receptor substrate 29
ITPR2inositol 1,4,5-trisphosphate receptor, type 214
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 19
KCNH2potassium voltage-gated channel, subfamily H (eag-related), member 220
KCNH3potassium voltage-gated channel, subfamily H (eag-related), member 310
KCNH5potassium voltage-gated channel, subfamily H (eag-related), member 51
KCNH6potassium voltage-gated channel, subfamily H (eag-related), member 61
KCNH7potassium voltage-gated channel, subfamily H (eag-related), member 720
KIR3DL1killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 120
KITLGv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog1
KLK9klotho20
Sykspleen tyrosine kinase3
SYKspleen tyrosine kinase13
LAG3lymphocyte-activation gene 310
LGALS9lectin, galactoside-binding, soluble, 91
SPNsialophorin60
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 11
LITAFlipopolysaccharide-induced TNF factor1
EDG4lysophosphatidic acid receptor 29
GPR92lysophosphatidic acid receptor 520
LPHN1latrophilin 11
LRP5low density lipoprotein receptor-related protein 51
LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor1
LHCGRluteinizing hormone/choriogonadotropin receptor20
LTBP4latent transforming growth factor beta binding protein 410
LTKleukocyte receptor tyrosine kinase9
MAP3K1mitogen-activated protein kinase kinase kinase 1022
MAP3K10mitogen-activated protein kinase kinase kinase 131
MAP3K13mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase20
MAP3K3mitogen-activated protein kinase kinase kinase 31
MAP3K7mitogen-activated protein kinase kinase kinase 738
MAP3K8mitogen-activated protein kinase kinase kinase 813
MAP4K1mitogen-activated protein kinase kinase kinase kinase 120
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 21
MAPK4mitogen-activated protein kinase 420
MLNRmotilin receptor50
MTNR1Bmelatonin receptor 1B30
GPR50G protein-coupled receptor 501
NLRP6NLR family, pyrin domain containing 61
NALP6NLR family, pyrin domain containing 61
NCR2natural cytotoxicity triggering receptor 220
NFAM1NFAT activating protein with ITAM motif 120
NGFBnerve growth factor (beta polypeptide)33
NISCHnischarin1
TACC1tachykinin receptor 11
TACR1tachykinin receptor 220
TACR2tachykinin receptor 320
NMBRneuromedin B receptor20
GRIN3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A30
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C1
GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D10
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 122
NPAS1neuronal PAS domain protein 129
NPAS3neuronal PAS domain protein 39
NPAS4neuronal PAS domain protein 420
NPBWR1neuropeptides B/W receptor 120
NPFFR1neuropeptide FF receptor 11
NPFFR2neuropeptide FF receptor 220
NPYneuropeptide Y receptor Y186
NPY1Rneuropeptide Y receptor Y21
NPY2Rneuropeptide Y receptor Y510
NPY5Rneuropeptide Y31
NR0B1nuclear receptor subfamily 0, group B, member 11
NR1D1nuclear receptor subfamily 1, group D, member 11
NR1I2nuclear receptor subfamily 1, group I, member 210
NR1I3nuclear receptor subfamily 1, group I, member 320
NR2E1nuclear receptor subfamily 2, group E, member 131
NR2F6nuclear receptor subfamily 2, group F, member 61
NR4A3nuclear receptor subfamily 4, group A, member 310
NR5A2nuclear receptor subfamily 5, group A, member 210
NR6A1nuclear receptor subfamily 6, group A, member 11
NRP1neuropilin 11
NRP2neuropilin 21
NTSR1neurotensin receptor 1 (high affinity)38
NTRK1neurotrophic tyrosine kinase, receptor, type 110
TrkAneurotrophic tyrosine kinase, receptor, type 12
NTRK2neurotrophic tyrosine kinase, receptor, type 231
NTRK3neurotrophic tyrosine kinase, receptor, type 362
OR13G1olfactory receptor, family 13, subfamily G, member 11
OR52N2olfactory receptor, family 52, subfamily N, member 21
OGFRopioid growth factor receptor1
OPCMLopioid binding protein/cell adhesion molecule-like1
OPRK1opioid receptor, kappa 140
OPRM1opioid receptor, mu 140
OR1E1olfactory receptor, family 1, subfamily E, member 120
OR2F1olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)20
OR2L13olfactory receptor, family 2, subfamily L, member 1329
OR2S2olfactory receptor, family 2, subfamily S, member 220
OR5I1olfactory receptor, family 5, subfamily I, member 120
OR7A5olfactory receptor, family 7, subfamily A, member 520
OSMRoncostatin M receptor10
HCRTR2hypocretin (orexin) receptor 21
OXGR1oxoglutarate (alpha-ketoglutarate) receptor 120
OXTRoxytocin receptor10
P2RY2purinergic receptor P2Y, G-protein coupled, 221
P2RY6pyrimidinergic receptor P2Y, G-protein coupled, 620
P2RY11purinergic receptor P2Y, G-protein coupled, 111
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)64
ADCYAP1R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I21
F2Rcoagulation factor II (thrombin) receptor20
PAX8paired box 810
GPR44prostaglandin D2 receptor 21
PTGDRprostaglandin D2 receptor (DP)29
PDE8Bphosphodiesterase 8B41
PTGER1prostaglandin E receptor 1 (subtype EP1), 42kDa9
PTGER3prostaglandin E receptor 3 (subtype EP3)30
PTGER4prostaglandin E receptor 4 (subtype EP4)9
PER3period circadian clock 31
PTGFRprostaglandin F receptor (FP)40
PGLYRP1peptidoglycan recognition protein 19
PGLYRP2peptidoglycan recognition protein 210
PLEKHG5pleckstrin homology domain containing, family G (with RhoGef domain) member 540
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)31
PROKR1prokineticin receptor 120
PROKR2prokineticin receptor 229
PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)20
PLXNA1plexin A11
PLXNA3plexin A310
PLXNA4plexin A410
PLXNB2plexin B210
PPARDperoxisome proliferator-activated receptor delta13
PPARGC1Bperoxisome proliferator-activated receptor gamma1
PPM1Aprotein phosphatase, Mg2+/Mn2+ dependent, 1A1
PGRprogesterone receptor12
PRLHRprolactin releasing hormone receptor40
PSDpleckstrin and Sec7 domain containing20
PTCH1patched 11
PTCH2patched 213
PTH1Rparathyroid hormone 1 receptor1
PTH2Rparathyroid hormone 2 receptor1
PTHR2parathyroid hormone 2 receptor29
PTCHD2patched domain containing 210
PTPN6protein tyrosine phosphatase, non-receptor type 613
PTPRNprotein tyrosine phosphatase, receptor type, N polypeptide 261
PTPRAprotein tyrosine phosphatase, receptor type, A1
PTPRDprotein tyrosine phosphatase, receptor type, D9
PTPRGprotein tyrosine phosphatase, receptor type, G10
PTPRHprotein tyrosine phosphatase, receptor type, H13
PTPRMprotein tyrosine phosphatase, receptor type, M30
PTPRN2protein tyrosine phosphatase, receptor type, N20
PTPROprotein tyrosine phosphatase, receptor type, O40
PTPRRprotein tyrosine phosphatase, receptor type, R20
PTPRSprotein tyrosine phosphatase, receptor type, S30
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 19
PVRpoliovirus receptor-related 1 (herpesvirus entry mediator C)41
GPR103pyroglutamylated RFamide peptide receptor40
RARAretinoic acid receptor, alpha96
RETret proto-oncogene43
RGS12regulator of G-protein signaling 129
RIPK3receptor-interacting serine-threonine kinase 333
RXFP3relaxin/insulin-like family peptide receptor 310
RLN3R1relaxin/insulin-like family peptide receptor 31
ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)10
MST1Rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)33
ROR2receptor tyrosine kinase-like orphan receptor 230
RORCRAR-related orphan receptor C9
EDG1sphingosine-1-phosphate receptor 120
S1PR3sphingosine-1-phosphate receptor 31
EDG3sphingosine-1-phosphate receptor 320
S1PR5sphingosine-1-phosphate receptor 51
SECTM1secreted and transmembrane 11
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D1
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A49
SEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A1
SFRP1secreted frizzled-related protein 1105
SARP2secreted frizzled-related protein 1235
SFRP2secreted frizzled-related protein 271
FRZBfrizzled-related protein63
SFRP4secreted frizzled-related protein 43
SFRP5secreted frizzled-related protein 52
SHC3SHC (Src homology 2 domain containing) transforming protein 31
SHHsonic hedgehog10
SIM1single-minded homolog 1 (Drosophila)50
SIM2single-minded homolog 2 (Drosophila)10
SMOC2smoothened, frizzled family receptor50
SORCS1sortilin-related VPS10 domain containing receptor 130
SORCS2sortilin-related VPS10 domain containing receptor 210
SORCS3sortilin-related VPS10 domain containing receptor 340
SSTR1somatostatin receptor 110
SSTR2somatostatin receptor 220
SSTR5somatostatin receptor 59
NR5A1nuclear receptor subfamily 5, group A, member 110
TGFB1transforming growth factor, beta 21
TGFB2transforming growth factor, beta receptor II (70/80kDa)13
THY1T-cell lymphoma invasion and metastasis 143
MUC2 CpG47mucin 2, oligomeric mucus/gel-forming2
TLL2toll-like receptor 929
TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, NFKB activator1
NGFRnerve growth factor receptor9
TNFRSF18tumor necrosis factor receptor superfamily, member 181
TNFRSF19tumor necrosis factor receptor superfamily, member 191
TNFRSF25tumor necrosis factor receptor superfamily, member 259
TNFRSF8tumor necrosis factor receptor superfamily, member 81
TOLLIPtoll interacting protein9
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a13
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain80
TGM5thrombomodulin20
TRIM54tripartite motif containing 549
TUBGCP3tubby homolog (mouse)10
UNC5CLunc-5 homolog C (C. elegans)20
PLAURplasminogen activator, urokinase receptor13
UTS2Rurotensin 2 receptor1
AVPR1Aarginine vasopressin receptor 1A10
AVPR2arginine vasopressin receptor 21
FLT1fms-related tyrosine kinase 143
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)14
FLT4fms-related tyrosine kinase 434
VIPR1vasoactive intestinal peptide receptor 11
VIPR2vasoactive intestinal peptide receptor 221
VLDLRvery low density lipoprotein receptor9
GPR177wntless homolog (Drosophila)1
ZP4zona pellucida glycoprotein 421
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