Representation of Major Biochemical Pathway categories by the genes in PCMdb


A list of genes in PCMdb that can be classified as "Positive Regulators of Signaling" by UniProt database has been provided below.
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Gene Symbol Gene Name # of Entries
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta1
HTR65-hydroxytryptamine (serotonin) receptor 6, G protein-coupled21
ADORA3adenosine A3 receptor9
CHRNB2cholinergic receptor, nicotinic, beta 2 (neuronal)1
ACVRL1activin A receptor type II-like 11
ADRA1Aadrenoceptor alpha 1A31
ADRA1Badrenoceptor alpha 1B1
ADRA2Aadrenoceptor alpha 2A10
ADRA2Badrenoceptor alpha 2B30
ADRA2Cadrenoceptor alpha 2C10
ADAM33ADAM metallopeptidase domain 81
ADAM8adenosine deaminase1
ADRB3adrenoceptor beta 351
JUBajuba LIM protein1
AKAP12A kinase (PRKA) anchor protein 1276
ALKBH4anaplastic lymphoma receptor tyrosine kinase1
FAM123BAPC membrane recruitment protein 19
ANKRD6ankyrin repeat domain 61
ARNTLaryl hydrocarbon receptor nuclear translocator1
ARRDC3arrestin domain containing 31
ASCL1achaete-scute complex homolog 1 (Drosophila)20
ACVR2Bactivin A receptor, type IIB13
BCL2L10BCL2-like 11 (apoptosis facilitator)11
BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)9
BCAP31B-cell receptor-associated protein 3110
BAXBCL2-associated X protein13
BCL10B-cell CLL/lymphoma 109
BCL2L2B-cell CLL/lymphoma 21
BIRC3baculoviral IAP repeat containing 31
BMP4bone morphogenetic protein 414
BMP6bone morphogenetic protein 69
BMP7bone morphogenetic protein 729
C1QTNF3C1q and tumor necrosis factor related protein 320
CDH11cadherin 13, H-cadherin (heart)70
CDH23cadherin 2, type 1, N-cadherin (neuronal)1
CARD9caspase recruitment domain family, member 910
CARTPTCART prepropeptide10
CARTCART prepropeptide51
CASP8caspase 8, apoptosis-related cysteine peptidase13
CAV2caveolin 21
CCL4chemokine (C-C motif) ligand 420
CCL5chemokine (C-C motif) ligand 520
CD44CD44 molecule (Indian blood group)5
CD8ACD8a molecule30
CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)20
p15cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)106
p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)2
CHP2calcineurin-like EF-hand protein 29
CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 11
CNTN2contactin 2 (axonal)20
COL1A1collagen, type I, alpha 113
CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 120
CRHR1corticotropin releasing hormone receptor 19
CRHR2corticotropin releasing hormone receptor 241
CRLF1cytokine receptor-like factor 19
CSF1Rcolony stimulating factor 1 receptor13
CSF2colony stimulating factor 2 (granulocyte-macrophage)14
CSF3colony stimulating factor 3 (granulocyte)13
SLC44A2solute carrier family 44, member 29
CXCR4chemokine (C-X-C motif) receptor 48
DCCdeleted in colorectal carcinoma192
DGKIdiacylglycerol kinase, iota40
DKK1dickkopf WNT signaling pathway inhibitor 16
DKK2dickkopf WNT signaling pathway inhibitor 246
DLL1delta-like 1 (Drosophila)9
DLX5distal-less homeobox 570
DRD1dopamine receptor D150
DRD2dopamine receptor D231
DRD4dopamine receptor D421
DUSP22dual specificity phosphatase 222
EDAectodysplasin A10
EEF1Deukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)1
EGR1early growth response 129
ELA2elastase, neutrophil expressed1
EPHA4EPH receptor A41
EPHA8EPH receptor A820
EPOerythropoietin50
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)49
ERepiregulin520
ESR1estrogen receptor 1109
EVC2Ellis van Creveld syndrome31
F7coagulation factor VII (serum prothrombin conversion accelerator)173
FGF1fibroblast growth factor 10233
FGF17fibroblast growth factor 1820
FGF18fibroblast growth factor 1 (acidic)11
FGF22fibroblast growth factor 2 (basic)9
FGF4fibroblast growth factor 421
FGFBP1fibroblast growth factor binding protein 120
FGFR1fibroblast growth factor receptor 114
FGFR2fibroblast growth factor receptor 214
FGFR3fibroblast growth factor receptor 31
FGFR4fibroblast growth factor receptor 413
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog1
FLNAfilamin A, alpha10
FLT3fms-related tyrosine kinase 342
FOXA1forkhead box A110
FOXD1forkhead box D19
FOXD2forkhead box D210
FZD1frizzled family receptor 1041
FZD5frizzled family receptor 51
FZD7frizzled family receptor 710
FZD8frizzled family receptor 89
GAS1growth arrest-specific 113
GAS6growth arrest-specific 610
GATA3GATA binding protein 311
GATA4GATA binding protein 421
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 11
GDF6growth differentiation factor 611
GDF7growth differentiation factor 711
SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 220
GFI1growth factor independent 1 transcription repressor10
GHRHRgrowth hormone releasing hormone receptor20
GHSRgrowth hormone secretagogue receptor30
NIPGIPC PDZ domain containing family, member 1141
GPR55G protein-coupled receptor 5520
GRIK1glutamate receptor, ionotropic, kainate 130
GRIK2glutamate receptor, ionotropic, kainate 220
GRM1glutamate receptor, metabotropic 120
HAND2heart and neural crest derivatives expressed 230
HAX1HCLS1 associated protein X-11
HBEGFheparin-binding EGF-like growth factor1
HCLS1hematopoietic cell-specific Lyn substrate 120
HES5hairy and enhancer of split 5 (Drosophila)1
HGFhepatocyte growth factor (hepapoietin A; scatter factor)20
HHEXhematopoietically expressed homeobox1
HIC1hypermethylated in cancer 126
IGFBP3insulin-like growth factor binding protein 3110
IGFBP5insulin-like growth factor binding protein 533
IFNGinterferon, gamma13
IL29interferon, lambda 11
IGF1Rinsulin-like growth factor 1 receptor10
IGF2BP3insulin-like growth factor 2 (somatomedin A)1
IHHindian hedgehog14
IL11interleukin 111
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)1
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)13
IL1Binterleukin 1, beta20
IL1RNinterleukin 1 receptor antagonist33
IL21Rinterleukin 220
ING2inhibitor of growth family, member 21
INSRinsulin receptor11
INSM2insulin10
ITPKBinositol-trisphosphate 3-kinase B21
IRAK1interleukin-1 receptor-associated kinase 19
IRF7interferon regulatory factor 730
IRS1insulin receptor substrate 11
ISL1ISL LIM homeobox 11
ITGA8integrin, alpha 850
JAK2Janus kinase 21
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 21
MAPK8IP3mitogen-activated protein kinase 8 interacting protein 310
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta21
KIF7kinesin family member 71
KITLGv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog1
KLK3kallikrein-related peptidase 620
KLK9klotho20
PRKCAprotein kinase C, alpha10
PRKCBprotein kinase C, beta31
PRKCB1protein kinase C, beta21
PRKD2protein kinase D21
PRKCHprotein kinase C, eta10
PRKCZprotein kinase C, zeta1
KSR2kinase suppressor of ras 210
Sykspleen tyrosine kinase3
SYKspleen tyrosine kinase13
LGALS9lectin, galactoside-binding, soluble, 91
LIFleukemia inhibitory factor13
LITAFlipopolysaccharide-induced TNF factor1
EDG4lysophosphatidic acid receptor 29
LHCGRluteinizing hormone/choriogonadotropin receptor20
LY86lymphocyte antigen 861
MAP3K1mitogen-activated protein kinase kinase kinase 1022
MAP3K13mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase20
MAP3K3mitogen-activated protein kinase kinase kinase 31
MAP3K7mitogen-activated protein kinase kinase kinase 738
MAP4K1mitogen-activated protein kinase kinase kinase kinase 120
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 21
MDFIMyoD family inhibitor domain containing12
MDFICMyoD family inhibitor1
MEN1multiple endocrine neoplasia I24
MSX1msh homeobox 1129
MSX2msh homeobox 21
MT3metallothionein 345
MYO1Cmyosin IC1
NCAM1neural cell adhesion molecule 140
SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 29
NEUROD2neuronal differentiation 220
OXToxytocin/neurophysin I prepropeptide20
NFAM1NFAT activating protein with ITAM motif 120
NGFBnerve growth factor (beta polypeptide)33
TACC1tachykinin receptor 11
NLGN2neuroligin 21
NLGN3neuroligin 31
CARD15nucleotide-binding oligomerization domain containing 213
NODALnodal growth differentiation factor10
NOTCH1notch 11
NOX4NADPH oxidase 41
NR2E1nuclear receptor subfamily 2, group E, member 131
NRG1neuregulin 123
NRXN1neurexin 111
NTF3neurotrophin 339
NTRK1neurotrophic tyrosine kinase, receptor, type 110
TrkAneurotrophic tyrosine kinase, receptor, type 12
NTRK2neurotrophic tyrosine kinase, receptor, type 231
NTRK3neurotrophic tyrosine kinase, receptor, type 362
OPRM1opioid receptor, mu 140
OXTRoxytocin receptor10
TP53tumor protein p532
TP73tumor protein p73100
p73tumor protein p7388
P73tumor protein p73156
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)64
PAK3p21 protein (Cdc42/Rac)-activated kinase 31
F2Rcoagulation factor II (thrombin) receptor20
GPR44prostaglandin D2 receptor 21
PDE5Aphosphodiesterase 5A, cGMP-specific1
PELI1pellino E3 ubiquitin protein ligase 11
COX2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)11
PIM2pim-2 oncogene10
PLEKHG5pleckstrin homology domain containing, family G (with RhoGef domain) member 540
AGPAT21-acylglycerol-3-phosphate O-acyltransferase 29
BVESblood vessel epicardial substance30
PPARDperoxisome proliferator-activated receptor delta13
PPM1Aprotein phosphatase, Mg2+/Mn2+ dependent, 1A1
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)20
PROK1prokineticin 121
PROK2prokineticin 249
PRRX1paired related homeobox 121
PTENphosphatase and tensin homolog9
PTGISprostaglandin I2 (prostacyclin) synthase30
PTPN6protein tyrosine phosphatase, non-receptor type 613
PTPRJprotein tyrosine phosphatase, receptor type, J20
RARAretinoic acid receptor, alpha96
NRASneuroblastoma RAS viral (v-ras) oncogene homolog1
RBPMSRNA binding protein with multiple splicing1
RELNreelin78
RETret proto-oncogene43
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 163
ARHGAP4Rho GTPase activating protein 41
ARHGAP6Rho GTPase activating protein 61
UBA52ubiquitin A-52 residue ribosomal protein fusion product 11
MST1Rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)33
ROR2receptor tyrosine kinase-like orphan receptor 230
RPTORregulatory associated protein of MTOR, complex 11
RRAGARas-related GTP binding A1
RSPO1R-spondin 121
RSPO2R-spondin 230
RUSC1RUN and SH3 domain containing 110
S100A4S100 calcium binding protein A453
SALL1sal-like 1 (Drosophila)31
KITKIT ligand15
SCRIBscribbled planar cell polarity protein1
SECTM1secreted and transmembrane 11
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D1
SFRP1secreted frizzled-related protein 1105
SARP2secreted frizzled-related protein 1235
SFRP2secreted frizzled-related protein 271
SFRP4secreted frizzled-related protein 43
SHANK3SH3 and multiple ankyrin repeat domains 31
SHC1SHC (Src homology 2 domain containing) transforming protein 11
SHHsonic hedgehog10
SKIv-ski sarcoma viral oncogene homolog (avian)41
SMOC2smoothened, frizzled family receptor50
SKIPSNW domain containing 140
SOCS2suppressor of cytokine signaling 2130
SOX10SRY (sex determining region Y)-box 111
SOX2SRY (sex determining region Y)-box 22
SPRED2sprouty-related, EVH1 domain containing 21
SRCIN1v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1
STK11serine/threonine kinase 119
LKB1serine/threonine kinase 1118
RBPJLrecombination signal binding protein for immunoglobulin kappa J region1
SNCAIPsynuclein, alpha (non A4 component of amyloid precursor)41
MAP3K7IP1TGF-beta activated kinase 1/MAP3K7 binding protein 120
MAP3K7IP3TGF-beta activated kinase 1/MAP3K7 binding protein 39
TBX15T-box 110
TNRC18tenascin R10
TCF7L1transcription factor 7-like 2 (T-cell specific, HMG-box)1
TFAP4trefoil factor 21
TFRCtransforming growth factor, alpha10
TGFAtransforming growth factor, beta 11
TGFB1transforming growth factor, beta 21
MUC2 CpG47mucin 2, oligomeric mucus/gel-forming2
TAAR5tachykinin, precursor 120
TLL2toll-like receptor 929
TNFSF10tumor necrosis factor (ligand) superfamily, member 1013
TNFSF11tumor necrosis factor (ligand) superfamily, member 1120
TNIP2TNFAIP3 interacting protein 29
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 29
TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, NFKB activator1
TNFRSF19tumor necrosis factor receptor superfamily, member 191
CART1TNF receptor-associated factor 440
TRAF7TNF receptor-associated factor 7, E3 ubiquitin protein ligase1
THthrombospondin 1416
TSPYL5TSPY-like 521
UBE3Aubiquitin protein ligase E3A1
VAV3vav 3 guanine nucleotide exchange factor20
FLT1fms-related tyrosine kinase 143
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)14
FLT4fms-related tyrosine kinase 434
SCAM-1sorbin and SH3 domain containing 30
VTNvitronectin20
GPR177wntless homolog (Drosophila)1
WNT10Awingless-type MMTV integration site family, member 10B9
WNT10Bwingless-type MMTV integration site family, member 111
WNT2wingless-type MMTV integration site family, member 2B41
WNT2Bwingless-type MMTV integration site family member 21
WNT3wingless-type MMTV integration site family, member 3A31
WNT5Awingless-type MMTV integration site family, member 5A10
WNT7Awingless-type MMTV integration site family, member 7A39
WNT9Awingless-type MMTV integration site family, member 9A9
XDHxanthine dehydrogenase40
XIAPX-linked inhibitor of apoptosis10
YAP1Yes-associated protein 165
ZEB2zinc finger E-box binding homeobox 210
ZNF423zinc finger protein 42340
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