Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_5303	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	HEYA8 MDR	4000 cells per well	NA	Alamar blue assay	33 PFU	100% cell killing	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5304	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	HEYA8 MDR	4000 cells per well	NA	Alamar blue assay	100 PFU	100% cell killing	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5305	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	0.1 PFU	100% cell viable	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5306	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	0.33 PFU	98% cell viable	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5307	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	1 PFU	50% cell viable	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5308	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	3.3 PFU	18% cell viable	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5309	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	10 PFU	15% cell viable	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5310	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	33 PFU	100% cell killing	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5311	Herpes simplex virus	M032	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and expressing human IL-12 gene	Yes	No	Virus expressing murine IL-12	NA	Human ovarian cancer cell line	SKOV3	4000 cells per well	NA	Alamar blue assay	100 PFU	100% cell killing	No	No	NA	No response	NA	NA	Tumor specific T cell response induced	NA	27784340
OV_5333	Herpes simplex virus	HSV2	DNA	Herpesviridae	Deletion mutant for ICP34.5 and ICP47 gene and insertion of GMCSF	Yes	No	Virus expressing GMCSF gene	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for CT26 (5.0E+5)	5.0E+6 pfu	NA	Reduction in tumor volume 1200 cubic mm compared to control 2500 cubic mm after 28 days	Intratumoral	Virus induced apoptosis as measured by TUNEL assay	Induce prolifration of tumor specific T cell	NA	28223815
OV_5363	Herpes simplex virus	HF10	DNA	Herpesviridae	None	Yes	No	No	NCI	Murine colon carcinoma cell line	MC26	4000 cells per well	Slightly toxic to lymphocytes	MTT assay	0.001 MOI	90% cell viability after 6 days	No	No	NA	No response	NA	NA	Stimulation of cytotoxic CD8 T cells	NA	28331843
OV_5364	Herpes simplex virus	HF10	DNA	Herpesviridae	None	Yes	No	No	NCI	Murine colon carcinoma cell line	MC26	4000 cells per well	Slightly toxic to lymphocytes	MTT assay	0.01 MOI	60% cell viability after 6 days	No	No	NA	No response	NA	NA	Stimulation of cytotoxic CD8 T cells	NA	28331843
OV_5365	Herpes simplex virus	HF10	DNA	Herpesviridae	None	Yes	No	No	NCI	Murine colon carcinoma cell line	MC26	4000 cells per well	Slightly toxic to lymphocytes	MTT assay	0.1 MOI	40% cell viability after 6 days	No	No	NA	No response	NA	NA	Stimulation of cytotoxic CD8 T cells	NA	28331843
OV_5366	Herpes simplex virus	HF10	DNA	Herpesviridae	None	Yes	No	No	NCI	Murine colon carcinoma cell line	MC26	4000 cells per well	Slightly toxic to lymphocytes	MTT assay	1 MOI	5% cell viability after 6 days	No	No	NA	No response	NA	NA	Stimulation of cytotoxic CD8 T cells	NA	28331843
OV_5367	Herpes simplex virus	HF10	DNA	Herpesviridae	None	Yes	No	No	NCI	Murine colon carcinoma cell line	MC26	4000 cells per well	Slightly toxic to lymphocytes	MTT assay	10 MOI	1% cell viability after 6 days	No	No	NA	No response	NA	NA	Stimulation of cytotoxic CD8 T cells	NA	28331843
OV_5368	Herpes simplex virus	HF10	DNA	Herpesviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c mice isograft for 1.0E+6 MC26 cells	1.0E+7 pfu on day 10, 17 and 24	NA	Reduction in tumor volume to 500 mm compared to control 2500 mm after 28 days and increase in survival time	Subcutaneous	NA	Stimulation of cytotoxic CD8 T cells	NA	28331843
OV_5460	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	60% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5461	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	30% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5462	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	5% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5463	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 4	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5464	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 5	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5465	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5466	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5467	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	75% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5468	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	60% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5469	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5470	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	10% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5471	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5472	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	35% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5473	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	20% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5474	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 3	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5475	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 4	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5476	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 5	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5477	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5478	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	90% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5479	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	58% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5480	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	50% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5481	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	20% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5482	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	5% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5483	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5585096
OV_5484	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	NA	NA	NA	Balb/c mice xenograft for U-87MG	5.0E+7 pfu	NA	Reduction in tumor growth below 2%	Intraneoplastic	NA	NA	NA	US5585096
OV_5485	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5 and ICP6 gene	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	NA	NA	NA	Balb/c mice xenograft for U-87MG	5.0E+7 pfu	NA	Reduction in tumor growth below 5%	Intraneoplastic	NA	NA	NA	US5585096
OV_5486	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	60% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5487	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	30% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5488	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	5% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5489	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 4	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5490	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 5	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5491	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5492	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5493	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	75% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5494	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	60% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5495	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5496	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	10% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5497	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5498	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	35% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5499	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	20% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5500	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 3	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5501	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 4	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5502	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 5	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5503	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5504	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	90% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5505	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	58% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5506	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	50% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5507	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	20% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5508	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	5% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5509	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US5728379
OV_5510	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	NA	NA	NA	Balb/c mice xenograft for U-87MG	5.0E+7 pfu	NA	Reduction in tumor growth below 2%	Intraneoplastic	NA	NA	NA	US5728379
OV_5511	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	NA	NA	NA	Balb/c mice xenograft for U-87MG	5.0E+7 pfu	NA	Reduction in tumor growth below 5%	Intraneoplastic	NA	NA	NA	US5728379
OV_5512	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	60% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5513	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	30% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5514	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	5% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5515	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 4	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5516	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 5	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5517	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5518	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5519	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	75% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5520	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	60% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5521	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5522	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	10% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5523	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5524	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	35% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5525	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	20% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5526	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 3	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5527	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 4	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5528	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 5	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5529	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	1 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5530	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	90% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5531	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	58% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5532	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	50% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5533	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	20% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5534	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	5% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5535	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	Trypan blue cell exclusion assay	0.01 MOI	100% cell death after day 6	No	No	NA	No response	NA	NA	NA	NA	US6139834
OV_5536	Herpes simplex virus	G207-1	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	NA	NA	NA	Balb/c mice xenograft for U-87MG	5.0E+7 pfu	NA	Reduction in tumor growth below 2%	Intraneoplastic	NA	NA	NA	US6139834
OV_5537	Herpes simplex virus	G207-2	DNA	Herpesviridae	Deletion mutant for gamma 34.5, ICP6 gene and ibonucleotide reductase	Yes	No	No	ATCC	Human glioma cell line	U-87 MG	NA	NA	NA	NA	NA	Balb/c mice xenograft for U-87MG	5.0E+7 pfu	NA	Reduction in tumor growth below 5%	Intraneoplastic	NA	NA	NA	US6139834
OV_5538	Herpes simplex virus	1716	DNA	Herpesviridae	Double deletion mutant in ICP34.5 gene	No	Virus in combination with mitomycin drug	No	ATCC	Human large cell carcinoma cell line H460	H460	NA	NA	NA	NA	NA	Mouse model xenograft for H460 cell line	4.0E+6 pfu	NA	Reduction in tumor volume to 0.793 +/- 0.047	Intravenously	NA	NA	NA	US6428968
OV_5539	Herpes simplex virus	1716	DNA	Herpesviridae	Double deletion mutant in ICP34.5 gene	Yes	No	No	ATCC	Human large cell carcinoma cell line H460	H460	NA	NA	NA	NA	NA	Mouse model xenograft for H460 cell line	4.0E+6 pfu	NA	Reduction in tumor volume to 1.127 +/- 0.139	Intravenously	NA	NA	NA	US6428968
OV_5540	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human medulloblastoma cell line	D283	NA	NA	NA	10 MOI	All cells was dead after 4 days	No	No	NA	No response	NA	NA	NA	NA	US6770274
OV_5541	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human medulloblastoma cell line	D283	NA	NA	NA	1 MOI	All cells was dead after 14 days	No	No	NA	No response	NA	NA	NA	NA	US6770274
OV_5542	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human medulloblastoma cell line	SNB40	NA	NA	NA	0.001 MOI	All cells was dead after 4 days	No	No	NA	No response	NA	NA	NA	NA	US6770274
OV_5543	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutatnt in TK gene and UL 24 gene	Yes	No	No	ATCC	Human medulloblastoma cell line	SNB40	NA	NA	NA	0.1 MOI	All cells was dead after 4 days	No	No	NA	No response	NA	NA	NA	NA	US6770274

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