Detailed description page of Selected OV_ID


OV_5538 details
Primary information
OV_IDOV_5538
Virus Name Herpes simplex virus
Strain1716
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDouble deletion mutant in ICP34.5 gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with mitomycin drug
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman large cell carcinoma cell line H460
Cell lineH460
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismMouse model xenograft for H460 cell line
In-vivo virus concentration4 ×10⁶
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 0.793 +/- 0.047
Mode of deliveryIntravenously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMIDUS6428968