Detailed description page of Selected OV_ID


OV_5539 details
Primary information
OV_IDOV_5539
Virus Name Herpes simplex virus
Strain1716
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDouble deletion mutant in ICP34.5 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman large cell carcinoma cell line H460
Cell lineH460
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismMouse model xenograft for H460 cell line
In-vivo virus concentration4 ×10⁶
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 1.127 +/- 0.139
Mode of deliveryIntravenously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMIDUS6428968