| Primary information |
|---|
| OV_ID | OV_5539 |
| Virus Name | Herpes simplex virus |
| Strain | 1716 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Double deletion mutant in ICP34.5 gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human large cell carcinoma cell line H460 |
| Cell line | H460 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Mouse model xenograft for H460 cell line |
| In-vivo virus concentration | 4 ×10ⶠ|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to 1.127 +/- 0.139 |
| Mode of delivery | Intravenously |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US6428968 |