| Primary information |
|---|
| OV_ID | OV_5511 |
| Virus Name | Herpes simplex virus |
| Strain | G207-2 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Deletion mutant for gamma 34.5, ICP4 gene and ibonucleotide reductase |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human glioma cell line |
| Cell line | U-87 MG |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Balb/c mice xenograft for U-87MG |
| In-vivo virus concentration | 5 ×10ⷠ|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor growth below 5% |
| Mode of delivery | Intraneoplastic |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US5728379 |