Detailed description page of Selected OV_ID


OV_5333 details
Primary information
OV_IDOV_5333
Virus Name Herpes simplex virus
StrainHSV2
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for ICP34.5 and ICP47 gene and insertion of GMCSF
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing GMCSF gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for CT26 (5 × 10⁵)
In-vivo virus concentration5 × 10⁶ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume 1200 cubic mm compared to control 2500 cubic mm after 28 days
Mode of deliveryIntratumoral
Pathway inductionVirus induced apoptosis as measured by TUNEL assay
Immunogenic effectInduce prolifration of tumor specific T cell
Clinical trialNA
PMID28223815