Detailed description page of Selected OV_ID


OV_5368 details
Primary information
OV_IDOV_5368
Virus Name Herpes simplex virus
StrainHF10
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c mice isograft for 1 × 10⁶ MC26 cells
In-vivo virus concentration1 × 10⁷ pfu on day 10, 17 and 24
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 500 mm compared to control 2500 mm after 28 days and increase in survival time
Mode of deliverySubcutaneous
Pathway inductionNA
Immunogenic effectStimulation of cytotoxic CD8 T cells
Clinical trialNA
PMID28331843