The Total number of records shown on this page is 78. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_3347	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	100% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3348	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	90% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3349	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	70% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3350	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	100% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3351	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	80% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3352	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	60% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3353	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	100% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3354	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	90% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3355	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	50% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3356	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	80% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3357	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	50% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3358	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	40% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3359	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	85% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3360	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	85% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3361	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	85% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3362	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	90% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3363	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	70% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3364	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	50% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3365	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	70% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3366	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	60% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3367	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1437	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	50% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3368	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	80% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3369	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3370	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3371	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	60% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3372	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	40% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3373	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	20% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3374	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	65% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3375	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	20% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3376	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	100% cell killing after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3377	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3378	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	80% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3379	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3380	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	80% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3381	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	50% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3382	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	30% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3383	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	80% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3384	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	50% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3385	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1563	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	100% cell killing after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3386	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3387	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3388	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3389	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	60% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3390	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	55% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3391	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	50% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3392	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	70% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3393	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	50% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3394	Reovirus	Recombinant reovirus T1L	RNA	Reoviridae	Mutant in L1 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	40% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3395	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3396	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3397	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	70% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3398	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	80% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3399	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	70% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3400	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	60% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3401	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	10 pfu	80% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3402	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	100 pfu	70% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_3403	Reovirus	Recombinant reovirus T3L	RNA	Reoviridae	Substitution mutant in T3 gene	Yes	No	No	ATCC	Human lung cancer cell line	H1975	1.0E+4 cells per well	NA	Cell-titer-glo assay	1000 pfu	50% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	28587298
OV_5552	Reovirus	Reovirus serotype 3	RNA	Reoviridae	None	Yes	No	No	ATCC	Human breast cancer cell line	MCF-7	60% confluency	NA	NA	40 MOI	Cell viability drops from 93 to 16% after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US6994858
OV_5553	Reovirus	Reovirus serotype 3	RNA	Reoviridae	None	Yes	No	No	ATCC	Human breast cancer cell line	SKBR3	60% confluency	NA	NA	40 MOI	Cell viability drops from 93 to 16% after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US6994858
OV_5554	Reovirus	Reovirus serotype 3	RNA	Reoviridae	None	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-468	60% confluency	NA	NA	40 MOI	Cell viability drops to 12.7% after 24 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US6994858
OV_5555	Reovirus	Reovirus serotype 3	RNA	Reoviridae	None	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-468	60% confluency	NA	NA	40 MOI	Cell viability drops to 8.8% after 48 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US6994858
OV_5556	Reovirus	Reovirus serotype 3	RNA	Reoviridae	None	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-468	60% confluency	NA	NA	40 MOI	Cell viability drops to 3.6% after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US6994858
OV_5562	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human keratinocytes	EN60	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5563	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	SUIT-2	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5564	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5565	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	PANC-1	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5566	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	MIAPaCa-2	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5573	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	SUIT-2	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for SUIT-2	1.0E+6 pfu	NA	Tumor volume reduced to below 1.0 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5576	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for BxPC3	1.0E+6 pfu	NA	Tumor volume reduced to below 3.0 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5579	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for MIAPaCa-2	1.0E+6 pfu	NA	Tumor volume reduced to below 4.0 cm after 12 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5584	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	Murine fibroblast cell line	THC-11	NA	NA	NA	NA	NA	SCID mice isograft for THC-11 (2.3E+5)	1.0E+7 pfu	NA	Reduction in tumor volume 284mg compared to control 602 mg after 3 weeks	Intratumoral	NA	NA	NA	US7374752
OV_5585	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	Murine fibroblast cell line	THC-11	NA	NA	NA	NA	NA	SCID mice isograft for THC-11 (4.8E+5)	1.0E+7 pfu	NA	Reduction in tumor volume 228mg compared to control 1523 mg after 3 weeks	Intratumoral	NA	NA	NA	US7374752
OV_5586	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	Murine fibroblast cell line	3T3	NA	NA	NA	NA	NA	SCID mice isograft for 3T3 (2.3E+5)	1.0E+7 pfu	NA	Reduction in tumor volume below 1 cm after 12 days	Intratumoral	NA	NA	NA	US7374752
OV_5587	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	Murine fibroblast cell line	3T3	NA	NA	NA	NA	NA	SCID mice isograft for 3T3 (4.8E+5)	1.0E+7 pfu	NA	Reduction in tumor volume below 1 cm after 12 days	Intratumoral	NA	NA	NA	US7374752
OV_5588	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	Human breast carcinoma cell line	MDA-MB-468	NA	NA	NA	NA	NA	SCID mice xenograft for MDA-MB468 (1.0E+5)	1.0E+7 pfu	NA	Reduction in tumor volume to 38.33gm compared to control 128.54 after 4 weeks	Intratumoral	NA	NA	NA	US7374752
OV_5679	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	SCID mice xenograft for MDA-MB468 (1.0E+5)	1.0E+7 pfu	NA	Reduction in tumor volume to 38.33gm compared to control 128.54 after 4 weeks	Intratumoral	NA	NA	NA	US7815914
OV_5680	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	C3H mice xenografted for ras transformed C3H cell line (1.0E+6)	5.0E+8 pfu	NA	Reduction in tumor volume to 60mm after 24 days	Intravenously	NA	NA	NA	US7964187
OV_5681	Reovirus	Reovirus strain T3D	RNA	Reoviridae	None	No	Virus strain in combination with cisplatin (2.5 mg/kg)	No	NA	NA	NA	NA	NA	NA	NA	NA	C3H mice xenografted for ras transformed C3H cell line (1.0E+6)	5.0E+8 pfu	NA	Reduction in tumor volume to 22mm after 24 days	Intravenously	NA	NA	NA	US7964187