| Primary information |
|---|
| OV_ID | OV_5681 |
| Virus Name | Reovirus |
| Strain | Reovirus strain T3D |
| Virus type | RNA |
| Virus family | Reoviridae |
| Modification in virus genome | None |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus strain in combination with cisplatin (2.5 mg/kg) |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C3H mice xenografted for ras transformed C3H cell line (1 ×10â¶) |
| In-vivo virus concentration | 5 ×10⸠pfu |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to 22mm after 24 days |
| Mode of delivery | Intravenously |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US7964187 |