| Primary information |
|---|
| OV_ID | OV_5576 |
| Virus Name | Reovirus |
| Strain | wild type |
| Virus type | RNA |
| Virus family | Reoviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | Human pancreatic cell line |
| Cell line | BxPC-3 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Nude mice xenografted subcutaneously for BxPC3 |
| In-vivo virus concentration | 1 ×10ⶠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume reduced to below 3.0 cm after 10 weeks |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis by virus infection |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US7270812B2 |