| Primary information |
|---|
| OV_ID | OV_5587 |
| Virus Name | Reovirus |
| Strain | Reovirus strain T3D |
| Virus type | RNA |
| Virus family | Reoviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | Murine fibroblast cell line |
| Cell line | 3T3 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | SCID mice isograft for 3T3 (4.8 ×10âµ) |
| In-vivo virus concentration | 1 ×10ⷠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume below 1 cm after 12 days |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US7374752 |