Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_1016	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	100 pfu/cell	50% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1017	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	1000 pfu/cell	20% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1018	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell kills after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1019	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	10 pfu/cell	10% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1020	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell kills after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1021	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell kills after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1022	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SHSY5Y	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell kills after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1023	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1024	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1025	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1026	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10000 pfu/cell	70% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1027	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1028	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	100 pfu/cell	80% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1029	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	1000 pfu/cell	75% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1030	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10000 pfu/cell	10% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1031	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10 pfu/cell	80% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1032	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	100 pfu/cell	50% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1033	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	1000 pfu/cell	30% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1034	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1035	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10 pfu/cell	50% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1036	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1037	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1038	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-79	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1039	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1040	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1041	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1042	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10000 pfu/cell	90% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1043	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10 pfu/cell	80% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1044	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	100 pfu/cell	80% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1045	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	1000 pfu/cell	80% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1046	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10000 pfu/cell	20% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1047	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10 pfu/cell	90% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1048	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	100 pfu/cell	60% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1049	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	1000 pfu/cell	20% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1050	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1051	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10 pfu/cell	10% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1052	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	100 pfu/cell	10% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1053	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	1000 pfu/cell	10% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1054	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	CHLA-20	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1055	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1056	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	100 pfu/cell	80% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1057	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	1000 pfu/cell	75% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1058	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10000 pfu/cell	30% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1059	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1060	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	100 pfu/cell	20% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1061	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	1000 pfu/cell	20% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1062	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1063	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1064	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1065	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1066	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1067	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10 pfu/cell	100% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1068	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1069	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1070	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SKNBE	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1071	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10 pfu/cell	80% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1072	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	100 pfu/cell	80% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1073	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	1000 pfu/cell	80% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1074	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10000 pfu/cell	80% cell survival after 2 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1075	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10 pfu/cell	80% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1076	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	100 pfu/cell	70% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1077	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	1000 pfu/cell	50% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1078	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10000 pfu/cell	30% cell survival after 4 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1079	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10 pfu/cell	70% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1080	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	100 pfu/cell	30% cell survival after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1081	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1082	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 6 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1083	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10 pfu/cell	20% cell survival after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1084	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1085	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1086	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	SMS-SAN	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1087	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	IMR-32	4.0E+3 cells per well	NA	NA	100 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1088	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	IMR-32	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1089	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	IMR-32	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1090	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	Lan-5	4.0E+3 cells per well	NA	NA	1000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1091	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	Neuroblastoma cell line	Lan-5	4.0E+3 cells per well	NA	NA	10000 pfu/cell	100% cell killing after 8 days	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15570577
OV_1092	Herpes simplex virus	HSV-1	DNA	Herpesviridae	Mutant NV1066	Yes	No	No	MediGene Inc. San Diego, CA	NA	NA	NA	NA	NA	NA	NA	Nude mice xenograft for CHLA-20	1.0E+7 pfu of NV1066" NA significant reduction in tumor size, shows 87.5 response rate Intratumoral injection Apoptosis induction and cspase 3 activation NA NA 15570577 OV_1093 Herpes simplex virus HSV-1 DNA Herpesviridae Mutant NV1066 Yes No No MediGene
OV_1139	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	ATCC	Human prostate cancer cell line	LNCaP	3.0E+5 cells per well	NA	MTT assay	0.01MOI	Kill cancer cell line after 3 days	No	No	NA	No response	NA	NA	NA	NA	16278413
OV_1140	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	ATCC	Human prostate cancer cell line	LNCaP	3.0E+5 cells per well	NA	MTT assay	0.1MOI	Kill cancer cell line after 3 days	No	No	NA	No response	NA	NA	NA	NA	16278413
OV_1141	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	ATCC	Human prostate cancer cell line	Du145	3.0E+5 cells per well	NA	MTT assay	0.01MOI	No cell killing after 3 days	No	No	NA	No response	NA	NA	NA	NA	16278413
OV_1142	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	ATCC	Human prostate cancer cell line	Du145	3.0E+5 cells per well	NA	MTT assay	0.1MOI	No cell killing after 3 days	No	No	NA	No response	NA	NA	NA	NA	16278413
OV_1143	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	ATCC	Human prostate cancer cell line	Du145	3.0E+5 cells per well	NA	MTT assay	0.01MOI	70% cell killing after 4 days	No	No	NA	No response	NA	NA	NA	NA	16278413
OV_1144	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	ATCC	Human prostate cancer cell line	Du145	3.0E+5 cells per well	NA	MTT assay	0.1MOI	70% cell killing after 4 days	No	No	NA	No response	NA	NA	NA	NA	16278413
OV_1145	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	C57BL/6 mice model isograft for TRAMP-C2 cell line	5.0E+6 pfu	NA	Reduction in tumor growth after repated dose of virus for 4 days	Intraneoplastically	NA	NA	NA	16278413
OV_1146	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Human prostatic cancer HONDA	2.0E+6 pfu	NA	Total reduction in tumor volume in 2 mice after 3 days	Intraneoplastically	NA	NA	NA	16278413
OV_1147	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	No	Virus strain in combination with androgen ablation therapy	No	NA	NA	NA	NA	NA	NA	NA	NA	C57BL/6 mice model isograft for TRAMP-C2 cell line	5.0E+6 pfu	NA	Reduction in tumor volume as compared to castration	Subcutaneous	NA	NA	NA	16278413
OV_1148	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	No	Virus strain in combination with flutamide	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Human prostatic cancer HONDA	No	NA	Significant reduction in tumor volume as compared to flutamide alone	Subcutaneous	NA	NA	NA	16278413
OV_1149	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	SW480	2.0E+4 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	70% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1150	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	SW620	1.0E+4 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	80% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1151	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	LoVo	5.0E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	60% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1152	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	WiDr	1.5E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	50% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1153	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	LS174T	5.0E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	70% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1154	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	Caco-2	5.0E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	80% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1155	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	HT-29	2.5E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	80% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1156	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	HCT-116	1.25E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	70% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1157	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	Yes	No	No	ATCC	Colon carcinoma cell line	CT-26	3.2E+2 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	90% cell killing	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1158	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	No	Virus strain in combination with 5-FU	No	ATCC	Colon carcinoma cell line	HT-29	1.0E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	Complete reduction in tumor,shows synergism with drug	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1159	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	No	Virus strain in combination with SN-38	No	ATCC	Colon carcinoma cell line	HT-29	1.0E+3 cells per well	NA	WST-1 assay	1 Ã— 10â¶ pfu/ml	Complete reduction in tumor,shows synergism with drug	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1160	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	No	Virus strain in combination with 5-FU	No	ATCC	Colon carcinoma cell line	WiDr	80cells per well	NA	WST-1 assay	1 Ã— 10â´ pfu/ml	Synergistic effect	No	No	NA	No response	NA	NA	NA	NA	17117895
OV_1161	Herpes simplex virus	NV1020	DNA	Herpesviridae	None	No	5-FU in combination with virus	No	ATCC	Colon carcinoma cell line	WiDr	80cells per well	NA	WST-1 assay	1 Ã— 10â´ pfu/ml	Synergistic effect	No	No	NA	No response	NA	NA	NA	NA	17117895

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