| Primary information |
|---|
| OV_ID | OV_1145 |
| Virus Name | Herpes simplex virus |
| Strain | Mutant |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Mutant for gamma 34.5, lacZ and alpha 47 gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C57BL/6 mice model isograft for TRAMP-C2 cell line |
| In-vivo virus concentration | 5 × 10ⶠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor growth after repated dose of virus for 4 days |
| Mode of delivery | Intraneoplastically |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 16278413 |