Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 90. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_729	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	10 MOI	97% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_731	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	52% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_733	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	33% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_735	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_737	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	50 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_739	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	100 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_741	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	80% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_742	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	50% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_743	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	65% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_744	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	45% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_745	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	61% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_746	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	61% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_747	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	46% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_748	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	46% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_1354	Adenovirus	CNHK300	DNA	Adenoviridae	None	Yes	No	No	ATCC	Hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	0.01 MOI	100% cell survival	No	No	NA	No response	NA	NA	NA	NA	18300357
OV_1355	Adenovirus	CNHK300	DNA	Adenoviridae	None	Yes	No	No	ATCC	Hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	0.1 MOI	90% cell survival	No	No	NA	No response	NA	NA	NA	NA	18300357
OV_1356	Adenovirus	CNHK300	DNA	Adenoviridae	None	Yes	No	No	ATCC	Hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	1 MOI	20% cell survival	No	No	NA	No response	NA	NA	NA	NA	18300357
OV_1357	Adenovirus	CNHK300	DNA	Adenoviridae	None	Yes	No	No	ATCC	Hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	10 MOI	20% cell survival	No	No	NA	No response	NA	NA	NA	NA	18300357
OV_1358	Adenovirus	CNHK300	DNA	Adenoviridae	None	Yes	No	No	ATCC	Hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	100 MOI	less than 20% cell survival	No	No	NA	No response	NA	NA	NA	NA	18300357
OV_1359	Adenovirus	CNHK300	DNA	Adenoviridae	None	Yes	No	No	ATCC	Hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	1000 MOI	less than 20% cell survival	No	No	NA	No response	NA	NA	NA	NA	18300357
OV_1916	Adenovirus	SG600-IL24	DNA	Adenoviridae	Addition of gene encoding IL24	Yes	No	Virus expressing IL-24 gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	90% cell viabilty after 24 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1917	Adenovirus	SG600-IL24	DNA	Adenoviridae	Addition of gene encoding IL24	Yes	No	Virus expressing IL-24 gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	70% cell viability after 48 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1918	Adenovirus	SG600-IL24	DNA	Adenoviridae	Addition of gene encoding IL24	Yes	No	Virus expressing IL-24 gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	60% cell viability after 72 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1919	Adenovirus	SG600-IL24	DNA	Adenoviridae	Addition of gene encoding IL24	Yes	No	Virus expressing IL-24 gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	30% cell viability after 96 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1928	Adenovirus	SG600-EGFP	DNA	Adenoviridae	Addition of gene encoding EGFP	Yes	No	Virus expressing EGFP gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	90% cell viabilty after 24 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1929	Adenovirus	SG600-EGFP	DNA	Adenoviridae	Addition of gene encoding EGFP	Yes	No	Virus expressing EGFP gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1930	Adenovirus	SG600-EGFP	DNA	Adenoviridae	Addition of gene encoding EGFP	Yes	No	Virus expressing EGFP gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	70% cell viability after 72 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_1931	Adenovirus	SG600-EGFP	DNA	Adenoviridae	Addition of gene encoding EGFP	Yes	No	Virus expressing EGFP gene	Institute of HCC, Fudan university	Human liver cancer cell line	HepG2	1.0E+3 cells per well	NA	MTT assay	10 MOI	65% cell viability after 96 hours	No	No	NA	No response	NA	Virus induce the apoptosis in HCC cell line	NA	NA	20872968
OV_2114	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2115	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2116	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	10 MOI	Most of the cells are died	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2117	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	100 MOI	Most of the cells are died	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2134	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2135	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2136	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	10 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2137	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	Crystal violet staining	100 MOI	Most of the cells are died	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2537	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	MTT assay	10 MOI	90% cells viable after day 1	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2538	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	MTT assay	10 MOI	80% cells viable after day 2	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2539	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	MTT assay	10 MOI	70% cells viable after day 3	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2540	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	MTT assay	10 MOI	60% cells viable after day 4	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2554	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	90.2% cell survival after 24 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2555	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	70.3% cell survival after 48 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2556	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	56.2% cell survival after 72 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2557	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	25.3% cell survival after 96 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2558	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	88.3% cell survival after 24 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2559	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	64% cell survival after 48 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2560	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	35.2% cell survival after 72 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2561	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HepG2	1000 cells	NA	MTT assay	10 MOI	17.7% cell survival after 96 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2588	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	HepG2	5.0E+4 cells per well	NA	MTT assay	10 MOI	10% cells are viable after 4 days	No	No	NA	No response	NA	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2665	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.01 MOI	100% cell survival after 24 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2666	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.01 MOI	100% cell survival after 48 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2667	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.01 MOI	100% cell survival after 72 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2668	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.01 MOI	100% cell survival after 96 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2669	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.1 MOI	100% cell survival after 24 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2670	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.1 MOI	90% cell survival after 48 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2671	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.1 MOI	80% cell survival after 72 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2672	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	0.1 MOI	60% cell survival after 96 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2673	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	1 MOI	90% cell survival after 24 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2674	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	1 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2675	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	1 MOI	70% cell survival after 72 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2676	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	2.0E+5 cells per well	NA	Cell proliferation assay kit	1 MOI	50% cell survival after 96 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_2689	Measles virus	MV-Edm	RNA	Paramyxoviridae	Insertion of human CEA gene upstream of MV N gene	Yes	No	No	ATCC	Human hepatoblastoma cell line	HepG2	NA	NA	NA	NA	NA	Nude mice xenograft for Hep2G (5.0E+6 cell)	1.0E+7 TCID50	NA	Reduction in tumor volume to 300mm after 37 days as compared to control 550mm and increase in survival time above 120 days as compared to control 30 days	Intratumoral	Induction of apoptosis in cancer	Increase expression of CD46	NA	23009685
OV_3057	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10â»â´ MOI	18% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3058	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10â»Â³ MOI	1% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3059	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10â»Â² MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3087	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10â»â´ MOI	15% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3088	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10â»Â³ MOI	1% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3089	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10â»Â² MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3111	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	No	Virus strain in combination with 5-FC (200mg/kg)	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	NA	NA	NA	BD62 mice xenograft for Lovo cell line	1.0E+7 pfu	NA	Tumor volume decreases to below 1500 mm after 50 days	Intravenous	NA	NA	NA	31011628
OV_3112	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	No	Virus strain in combination with 5-FC (200mg/kg)	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	NA	NA	NA	BD62 mice xenograft for Lovo cell line	1.0E+7 pfu	NA	Tumor volume decreases to below 1000 mm after 50 days	Intravenous	NA	NA	NA	31011628
OV_3623	Measles virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human liver cancer cell line	HepG2	5000 cells per well	NA	MTT assay	1 MOI	60% cell viability after day 3	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29485292
OV_3624	Measles virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human liver cancer cell line	HepG2	5000 cells per well	NA	MTT assay	1 MOI	20% cell viability after day 6	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29485292
OV_3637	Mumps virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human liver cancer cell line	HepG2	5000 cells per well	NA	MTT assay	1 MOI	100% cell viability after day 3	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29485292
OV_3638	Mumps virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human liver cancer cell line	HepG2	5000 cells per well	NA	MTT assay	1 MOI	100% cell viability after day 6	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29485292
OV_3651	Measles and mumps virus	wild type	RNA	Paramyxoviridae	None	No	Measles virus in combination with mumps virus	No	ATCC	Human liver cancer cell line	HepG2	5000 cells per well	NA	MTT assay	1 MOI	70% cell viability after day 3	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29485292
OV_3652	Measles and mumps virus	wild type	RNA	Paramyxoviridae	None	No	Measles virus in combination with mumps virus	No	ATCC	Human liver cancer cell line	HepG2	5000 cells per well	NA	MTT assay	1 MOI	18% cell viability after day 6	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29485292
OV_4319	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma	HepG2	4000 cells per well	NA	MTT assay	10 pfu	88.6 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_5205	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5206	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5207	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5208	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5209	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5210	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5211	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5212	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5213	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	20% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5334	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	0.01 MOI	56.7% cells remain viable	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5335	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	0.1 MOI	43.2% cells remain viable	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5336	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	1 MOI	29.6% cells remain viable	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5337	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	10 MOI	20.8% cell growth inhibition	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027