Detailed description page of Selected OV_ID


OV_743 details
Primary information
OV_IDOV_743
Virus Name Adenovirus
StrainAdAFPp-E1A-122
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeThe viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHepG2 with mimics
Concentration of cell line1
In-vitro toxicitySlight toxicity to HL-7702 cell line
AssayMTT assay
In-vitro virus concentration100 MOI
In-vitro result65% cancer cell viability on day 3
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27450327