Detailed description page of Selected OV_ID


OV_746 details
Primary information
OV_IDOV_746
Virus Name Adenovirus
StrainAdAFPp-E1A
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeThe viral mutant with E1A gene driven by AFP promoter
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHepG2 with negative control
Concentration of cell line1
In-vitro toxicitySlight toxicity to HL-7702 cell line
AssayMTT assay
In-vitro virus concentration50 MOI
In-vitro result61% cancer cell viability on day 3
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27450327