| Primary information |
|---|
| OV_ID | OV_744 |
| Virus Name | Adenovirus |
| Strain | AdAFPp-E1A-122 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China |
| Origin of cell line | Human hepatocellular carcinoma cell line |
| Cell line | HepG2 with negative control |
| Concentration of cell line | 1 |
| In-vitro toxicity | Slight toxicity to HL-7702 cell line |
| Assay | MTT assay |
| In-vitro virus concentration | 100 MOI |
| In-vitro result | 45% cancer cell viability on day 3 |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27450327 |