Detailed description page of Selected OV_ID


OV_2689 details
Primary information
OV_IDOV_2689
Virus Name Measles virus
StrainMV-Edm
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeInsertion of human CEA gene upstream of MV N gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman hepatoblastoma cell line
Cell lineHepG2
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNude mice xenograft for Hep2G (5 × 10⁶ cell)
In-vivo virus concentration1 × 10⁷ TCID/50
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 300mm after 37 days as compared to control 550mm and increase in survival time above 120 days as compared to control 30 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis in cancer
Immunogenic effectIncrease expression of CD46
Clinical trialNA
PMID23009685