| Primary information |
|---|
| OV_ID | OV_2689 |
| Virus Name | Measles virus |
| Strain | MV-Edm |
| Virus type | RNA |
| Virus family | Paramyxoviridae |
| Modification in virus genome | Insertion of human CEA gene upstream of MV N gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human hepatoblastoma cell line |
| Cell line | HepG2 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Nude mice xenograft for Hep2G (5 × 10ⶠcell) |
| In-vivo virus concentration | 1 × 10ⷠTCID/50 |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to 300mm after 37 days as compared to control 550mm and increase in survival time above 120 days as compared to control 30 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis in cancer |
| Immunogenic effect | Increase expression of CD46 |
| Clinical trial | NA |
| PMID | 23009685 |