Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 148. Click on ID to see further detail.
IDOV_606Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_609Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_612Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_615Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result10% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_717Virus nameAvian influenza A virusVirus strainH7N3 NS1-77Virus genome typeRNAVirus familyOrthomyxoviridaeVirus genome modificationMutations were introduced within the IAV NS1 gene to create a truncated protein of 77 aa (NS1-77)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayImmunoassay detectionIn-vitro virus concentration0.001 MOIIn-vitro result130% cancer cell death (calculated as relative to mock-infected)Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUp-regulation of IFN-aplhaClinical trialNAPMID27417501
IDOV_721Virus nameAvian influenza A virusVirus strainH7N3Virus genome typeRNAVirus familyOrthomyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayImmunoassay detectionIn-vitro virus concentration0.001 MOIIn-vitro result148% cancer cell death (calculated as relative to mock-infected)Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUp-regulation of IFN-aplhaClinical trialNAPMID27417501
IDOV_898Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result2% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_899Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result20% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_900Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result50% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_901Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result20% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_902Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result40% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_903Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result80% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_904Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result60% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_905Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result80% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_906Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result90% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_907Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result20% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_908Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result30% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_909Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result50% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_910Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result50% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_911Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result60% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_912Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result100% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_913Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result60% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_914Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result80% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_915Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result100% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_1261Virus nameAdenovirusVirus strainAxdAdb-3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDouble mutated for E1A and E1B geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityAssayMTT assayIn-vitro virus concentration30 MOIIn-vitro resultSurviving cell number reached to 10000Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18063085
IDOV_1290Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration0.1 MOIIn-vitro result98% cell viability after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1291Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration0.1 MOIIn-vitro result90% cell viability after day 2Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1292Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1293Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration0.1 MOIIn-vitro result98% cell viability after day 4Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1294Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration1 MOIIn-vitro result98% cell viability after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1295Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration1 MOIIn-vitro result80% cell viability after day 2Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1296Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1297Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration1 MOIIn-vitro result60% cell viability after day 4Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1298Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration10 MOIIn-vitro result60% cell viability after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1299Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after day 2Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1300Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration10 MOIIn-vitro result30% cell viability afterd ay 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1301Virus nameAdenovirusVirus strainOBP-301Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line1000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit by Roche DiagnosticsIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after day 4Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18274558
IDOV_1408Virus nameParovirusVirus strainH-1PVVirus genome typeDNAVirus familyParoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with norfloxacin (25 microgram/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis, activation of caspase 3Immunogenic effectNAClinical trialNAPMID19301953
IDOV_1409Virus nameParovirusVirus strainH-1PVVirus genome typeDNAVirus familyParoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with norfloxacin (25 microgram/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis, activation of caspase 3Immunogenic effectNAClinical trialNAPMID19301953
IDOV_2014Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2015Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2016Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration10 MOIIn-vitro result10% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2017Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration100 MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2026Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (7.5 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.125 MOIIn-vitro result80% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2027Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (15 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.25 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2028Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (30 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.5 MOIIn-vitro result60% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2029Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (60 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2030Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration2 MOIIn-vitro result40% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2278Virus nameVesicular stomatitis virusVirus strainwild typeVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2292Virus nameVesicular stomatitis virusVirus strainVSV-Delta-M51-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationDeletion of M51 gene and insertion of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2306Virus nameVesicular stomatitis virusVirus strainVSV-p1-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationInsertion of P geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2320Virus nameVesicular stomatitis virusVirus strainSev-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationInsertion of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2334Virus nameVesicular stomatitis virusVirus strainRSV-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationInsertion of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2348Virus nameVesicular stomatitis virusVirus strainwild typeVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2362Virus nameVesicular stomatitis virusVirus strainVSV-Delta-M51-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationDeletion of M51 gene and insertion of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2376Virus nameVesicular stomatitis virusVirus strainVSV-p1-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationInsertion of P geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2390Virus nameVesicular stomatitis virusVirus strainSev-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationVirus expressing GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_2404Virus nameVesicular stomatitis virusVirus strainRSV-GFPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationVirus expressing GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell linePancreatic ductal adeonocarcinoma cell lineCell lineBxPC-3Concentration of cell line80% confluent monolayerIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after 5 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectDownregulation of IFN-GammaClinical trialNAPMID22238308
IDOV_3404Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.001 MOIIn-vitro resultNo cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3405Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.005 MOIIn-vitro resultNo cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3406Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.01 MOIIn-vitro resultNo cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3407Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.05 MOIIn-vitro result35% cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3408Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3424Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with gemcitabine (2 × 10⁻² micromolar) after 1 hourImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.01 MOIIn-vitro result75% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3425Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with gemcitabine (2 × 10⁻² micromolar) after 24 hourImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.01 MOIIn-vitro result75% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3432Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (1 × 10⁻² micromolar) after 1 hourImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.01 MOIIn-vitro result25% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3433Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (1 × 10⁻² micromolar) after 24 hourImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.01 MOIIn-vitro result50% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3440Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.01 MOIIn-vitro result70% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3441Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.03 MOIIn-vitro result60% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3442Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssaySRB assayIn-vitro virus concentration0.05 MOIIn-vitro result52% of the tumor cell mass remain after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3443Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssayCTB assayIn-vitro virus concentration0.01 MOIIn-vitro result50% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3444Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssayCTB assayIn-vitro virus concentration0.03 MOIIn-vitro result40% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3445Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of three gene beta-glucouronidase, galactosidase and GFPVirus aloneNoVirus in combination with drug/radiationVirus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic adenocarcinoma cell lineCell lineBxPC-3Concentration of cell line4.0E+4 cells per wellIn-vitro toxicityNAAssayCTB assayIn-vitro virus concentration0.05 MOIIn-vitro result30% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28607950
IDOV_3538Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3539Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result80% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3540Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3541Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result58% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3542Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3543Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3544Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3545Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3619Virus nameMeasles virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3620Virus nameMeasles virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result20% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3633Virus nameMumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3634Virus nameMumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3647Virus nameMeasles and mumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationMeasles virus in combination with mumps virusImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3648Virus nameMeasles and mumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationMeasles virus in combination with mumps virusImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result12% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3723Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration0.1 MOIIn-vitro result15% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3724Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3M-LucConcentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3730Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration10 MOIIn-vitro result15% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3731Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3M-LucConcentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration10 MOIIn-vitro result18% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3753Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.0001 MOIIn-vitro result100% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3754Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.001 MOIIn-vitro result100% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3755Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result98% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3756Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3757Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result100% cell killing after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3758Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration3 MOIIn-vitro result100% cell killing after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3767Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneNoVirus in combination with drug/radiationVirus in combination with gemcitabine (1 micromolar)Immune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result60% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3768Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneNoVirus in combination with drug/radiationVirus in combination with gemcitabine (1 micromolar)Immune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result50% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3769Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneNoVirus in combination with drug/radiationVirus in combination with gemcitabine (5 micromolar)Immune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_3770Virus nameVaccinia virusVirus strainvv-smacVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of smac and gpt gene in TKVirus aloneNoVirus in combination with drug/radiationVirus in combination with gemcitabine (5 micromolar)Immune gene insertion in viral genomeNoSource of cell lineType culture collection of chinaOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result30% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis in cancer cellImmunogenic effectNAClinical trialNAPMID30365143
IDOV_4126Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneNoVirus in combination with drug/radiationVirus in combination with drug Gemcitabine (0.01 ng/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 vp/cellIn-vitro result80% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4127Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneNoVirus in combination with drug/radiationVirus in combination with drug Gemcitabine (1 ng/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1000 vp/cellIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4128Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneNoVirus in combination with drug/radiationVirus in combination with drug Gemcitabine (10 ng/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10000 vp/cellIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4129Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneNoVirus in combination with drug/radiationVirus in combination with drug Gemcitabine (100 ng/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100000 vp/cellIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4130Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneNoVirus in combination with drug/radiationVirus in combination with drug Gemcitabine (1000 ng/ml)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1000000 vp/cellIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4131Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 vp/cellIn-vitro result100% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4132Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1000 vp/cellIn-vitro result85% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4133Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10000 vp/cellIn-vitro result35% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4134Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100000 vp/cellIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4135Virus nameAdenovirusVirus strainAduPARE1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of E1A gene upstream of uPAR promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1000000 vp/cellIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26227809
IDOV_4308Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate adenocarcinomaCell linePC-3Concentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result72.7 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_4330Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreas adenocarcinomaCell lineBxPC-3Concentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result98.8 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_4909Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4910Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4911Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4912Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4913Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4914Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4915Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result30% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4916Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result15% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4917Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4918Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4919Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result15% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4920Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result15% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_5065Virus nameAvian orthoreovirusVirus strainARV-PB1Virus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePC-3Concentration of cell line1.0E+3 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result80% cell viability after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28441762
IDOV_5072Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5073Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result98% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5074Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration4 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5075Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5076Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 MOIIn-vitro result55% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5077Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationVirus in combination with SNS032 5ng/mlImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result55% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5078Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationVirus in combination with SNS032 10ng/mlImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result45% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5079Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationVirus in combination with SNS032 20ng/mlImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration4 MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5080Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationVirus in combination with SNS032 40ng/mlImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 MOIIn-vitro result20% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5081Virus nameAdenovirusVirus strainZD-55-TRAIl-IETD-smacVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of TRAIL and smac gene via IETD linkerVirus aloneYesVirus in combination with drug/radiationVirus in combination with SNS032 80ng/mlImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman pancreatic cancer cell lineCell lineBxPC-3Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28440486
IDOV_5559Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayNAIn-vitro virus concentration1 MOIIn-vitro resultSignificant death of cancer cell line after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5564Virus nameReovirusVirus strainwild typeVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayNAIn-vitro virus concentration1 MOIIn-vitro resultSignificant death of cancer cell line after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5569Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationSindbis virus in combination with ReovirusImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayNAIn-vitro virus concentration1 MOIIn-vitro resultEnhancer cytolytic effect in combination after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5575Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenografted subcutaneously for BxPC3In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 2.0 cm after 10 weeksMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5576Virus nameReovirusVirus strainwild typeVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenografted subcutaneously for BxPC3In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 3.0 cm after 10 weeksMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5577Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationSindbis virus in combination with ReovirusImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenografted subcutaneously for BxPC3In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultComplete reduction in tumor volume after 10 weeksMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5578Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenografted subcutaneously for MIAPaCa-2In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 5.0 cm after 12 weeksMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5579Virus nameReovirusVirus strainwild typeVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman pancreatic cell lineCell lineBxPC-3Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenografted subcutaneously for MIAPaCa-2In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 4.0 cm after 12 weeksMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virus infectionImmunogenic effectNAClinical trialNAPMIDUS7270812B2
IDOV_5623Virus nameNewcastle disease virusVirus strainNDV-MK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell line80% confluencyIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration3×10³ pfuIn-vitro result50% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectInduction of IFN-Gamma productionClinical trialNAPMIDUS7470426
IDOV_5843Virus nameNewcastle disease virusVirus strainNDV-PPMK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostae carcinoma cell lineCell linePC-3Concentration of cell line80% confluencyIn-vitro toxicityNAAssayNAIn-vitro virus concentration3.1 ×10³ pfuIn-vitro result50% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS8105578
IDOV_5888Virus nameRespiratory synctial virusVirus strainMutantVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result20% cell survived after treatmentModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMIDUS9241998
IDOV_5893Virus nameAdenovirusVirus strainCGTG-602Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus E1A promoter is replaced by human E2F1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3-MM2Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 ×10⁴ pfuIn-vitro resultAll cell death occurs after 100 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9410129