| Primary information |
|---|
| OV_ID | OV_3770 |
| Virus Name | Vaccinia virus |
| Strain | vv-smac |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Insertion of smac and gpt gene in TK |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with gemcitabine (5 micromolar) |
| Immune gene induction in virus genome | No |
| Source of cell line | Type culture collection of china |
| Origin of cell line | Human pancreatic cancer cell line |
| Cell line | BxPC-3 |
| Concentration of cell line | 5 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 0.5 MOI |
| In-vitro result | 30% cell viability after 48 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Virus induce apoptosis in cancer cell |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 30365143 |