Detailed description page of Selected OV_ID


OV_5577 details
Primary information
OV_IDOV_5577
Virus Name Sindbis virus
StrainAR339
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationSindbis virus in combination with Reovirus
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineHuman pancreatic cell line
Cell lineBxPC-3
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNude mice xenografted subcutaneously for BxPC3
In-vivo virus concentration1 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultComplete reduction in tumor volume after 10 weeks
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis by virus infection
Immunogenic effectNA
Clinical trialNA
PMIDUS7270812B2