The total number of records retrieved from this search are 89. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_2707	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus in combination with CIK	Virus expressing IL-12 gene	ATCC	Human hepatocellular carcinoma cell line	Hep3B	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	10% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2708	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus strain in combination with CIK (1 × 10⁷ )	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	SCID mice xenograft for Huh7 (1.0E+6 cell)	2.0E+8 pfu	NA	Reduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days	Intratumoral	NA	NA	NA	23028626
OV_2709	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus strain in combination with CIK (1 × 10⁷ )	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	SCID mice xenograft for Huh7 (1.0E+6 cell)	2.0E+8 pfu	NA	Reduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days	Intravenous	NA	NA	NA	23028626
OV_2731	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	100% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2732	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2733	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	60% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2734	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	50% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2735	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2736	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2737	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	50% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2738	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	PLC5	1.0E+4 cells per well	NA	MTT assay	5 MOI	30% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2739	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	100% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2740	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2741	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	82% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2742	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	78% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2743	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2744	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2745	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	60% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2746	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	BEL-7404	1.0E+4 cells per well	NA	MTT assay	5 MOI	40% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2747	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2748	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2749	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	60% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2750	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	40% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2751	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2752	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	50% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2753	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	30% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2754	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	20% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2755	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh cell (2.0E+6 cell)	7.0E+8 pfu	NA	Complete regression in tumor volume after 49 days	Intratumoral	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_3057	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10⁻⁴ MOI	18% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3058	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10⁻³ MOI	1% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3059	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10⁻² MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3087	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10⁻⁴ MOI	15% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3088	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10⁻³ MOI	1% cell viability	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3089	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	3.0E+5 cells per well	NA	Trypan blue assay	10⁻² MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	31011628
OV_3111	Vaccinia virus	DeltaJ2R/FCU1 VACV	DNA	Poxviridae	Deletion of J2R gene and insertion of gene FCU1	No	Virus strain in combination with 5-FC (200mg/kg)	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	NA	NA	NA	BD62 mice xenograft for Lovo cell line	1.0E+7 pfu	NA	Tumor volume decreases to below 1500 mm after 50 days	Intravenous	NA	NA	NA	31011628
OV_3112	Vaccinia virus	DeltaJ2R-I4L/FCU1 VACV (TG6002)	DNA	Poxviridae	Deletion of J2R and I4L gene and insertion of gene FCU1	No	Virus strain in combination with 5-FC (200mg/kg)	No	ATCC	Human hepatocellular carcinoma cell line	HepG2	NA	NA	NA	NA	NA	BD62 mice xenograft for Lovo cell line	1.0E+7 pfu	NA	Tumor volume decreases to below 1000 mm after 50 days	Intravenous	NA	NA	NA	31011628
OV_4276	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Hep3B	4000 cells per well	NA	MTT assay	10 pfu	3.8 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4299	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma	Huh-7	4000 cells per well	NA	MTT assay	10 pfu	52.2 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4302	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatoblastoma	Huh-6	4000 cells per well	NA	MTT assay	10 pfu	59 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4307	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	SICB	Human hepatoma	Li-7	4000 cells per well	NA	MTT assay	10 pfu	72.1 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4312	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	SICB	Human hepatoma	PLC	4000 cells per well	NA	MTT assay	10 pfu	80.5 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4319	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma	HepG2	4000 cells per well	NA	MTT assay	10 pfu	88.6 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4338	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatoblastoma	Huh-6	4000 cells per well	NA	MTT assay	0.001 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4339	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatoblastoma	Huh-6	4000 cells per well	NA	MTT assay	0.01 MOI	98% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4340	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatoblastoma	Huh-6	4000 cells per well	NA	MTT assay	0.1 MOI	90% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4341	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatoblastoma	Huh-6	4000 cells per well	NA	MTT assay	10 MOI	78% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4342	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatoblastoma	Huh-6	4000 cells per well	NA	MTT assay	100 MOI	62% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4877	Adenovirus	Ad-deltaB	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma	Hep3B	70% confluence on 24 well plate	NA	MTT assay	5 MOI	100% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4878	Adenovirus	Ad-deltaB	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma	Hep3B	70% confluence on 24 well plate	NA	MTT assay	10 MOI	90% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4879	Adenovirus	Ad-deltaB	DNA	Adenoviridae	Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Yes	No	Virus expressing IL12 gene	ATCC	Human hepatocellular carcinoma	Hep3B	70% confluence on 24 well plate	NA	MTT assay	10 MOI	50% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4880	Adenovirus	Ad-deltaB	DNA	Adenoviridae	Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Yes	No	Virus expressing IL12 gene	ATCC	Human hepatocellular carcinoma	Hep3B	70% confluence on 24 well plate	NA	MTT assay	20 MOI	40% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4881	Adenovirus	Ad-deltaB	DNA	Adenoviridae	None	Yes	No	No	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	5 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4882	Adenovirus	Ad-deltaB	DNA	Adenoviridae	None	Yes	No	No	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	10 MOI	60% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4883	Adenovirus	Ad-deltaB	DNA	Adenoviridae	Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Yes	No	Virus expressing IL12 gene	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	10 MOI	20% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4884	Adenovirus	Ad-deltaB	DNA	Adenoviridae	Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Yes	No	Virus expressing IL12 gene	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	20 MOI	10% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_5052	Vaccinia virus	VG9	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	0.1 MOI	50% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5053	Vaccinia virus	VG9	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	1 MOI	35% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5054	Vaccinia virus	VG9	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	10 MOI	20% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5055	Vaccinia virus	VG9-EGFP	DNA	Poxviridae	Addition of EGFP gene in tk locus	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	0.1 MOI	50% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5056	Vaccinia virus	VG9-EGFP	DNA	Poxviridae	Addition of EGFP gene in tk locus	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	1 MOI	35% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5057	Vaccinia virus	VG9-EGFP	DNA	Poxviridae	Addition of EGFP gene in tk locus	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	10 MOI	22% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5058	Vaccinia virus	WR-EGFP	DNA	Poxviridae	Addition of EGFP gene in tk locus	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	0.1 MOI	50% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5059	Vaccinia virus	WR-EGFP	DNA	Poxviridae	Addition of EGFP gene in tk locus	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	1 MOI	35% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5060	Vaccinia virus	WR-EGFP	DNA	Poxviridae	Addition of EGFP gene in tk locus	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	SMMC7721	1.0E+4 cells per well	NA	MTT assay	10 MOI	21% cell viability after 3 days	No	No	NA	No response	NA	NA	NA	NA	28465492
OV_5205	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5206	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5207	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5208	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5209	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5210	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5211	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5212	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5213	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	20% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5214	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5215	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5216	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5217	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5218	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5219	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5220	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5221	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5222	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	20% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5334	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	0.01 MOI	56.7% cells remain viable	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5335	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	0.1 MOI	43.2% cells remain viable	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5336	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	1 MOI	29.6% cells remain viable	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5337	Newcastle disease virus	NDV/Anh-TRAIL	RNA	Paramyxoviridae	Virus insertion for TRAIL gene	Yes	No	No	China Xiehe Medical University	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	10 MOI	20.8% cell growth inhibition	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	Caspase 3 pathway are activated	NA	28246027
OV_5340	Newcastle disease virus	LaSota	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	5.0E+4 cells per well	NA	MTT assay	0.001 MOI	37% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induce apoptosis	Induced production of IFN-alpha, IFN-beta, IL-6and IFN-gamma	NA	28293547
OV_5669	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Hep3B	NA	NA	MTT assay	0.01 MOI	Complete cancer cell death	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5670	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Hep3B	NA	NA	MTT assay	1 MOI	Complete cancer cell death after day 5	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418