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Non-peptide Hormone

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HMRbase accession number1033
PubChem ID222786
Hormone nameCortisone
DescriptionA naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
SynonymsAdrenalex Cortisate Cortistal Cortivite Andreson Cortisal Cortogen Cortone Adreson Cortisone
Molecular weight360.44
Molecular formulaC21H28O5
IUPAC Name(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
Canonical smilesCC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
Isomeric smilesC[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C
Structure
   
PDB file
SDF file
MOL file
PDB ID3EB3  
KEGG IDC00762  D07749  
HMDB IDHMDB02802
Melting Point222(EXP)
Log P1.47(EXP)
Water Solubility280(EXP) at 25C
DrugBank IDN/A
Drugpediawiki
ReceptorP79686   Detail in HMRbase   
Q6XLJ0   Detail in HMRbase   
P49115   Detail in HMRbase   
P04150   Detail in HMRbase   
P06537   Detail in HMRbase   
P49843   Detail in HMRbase   
O73673   Detail in HMRbase   
Q9N1U3   Detail in HMRbase   
Q5R9P5   Detail in HMRbase   
P59667   Detail in HMRbase   
P06536   Detail in HMRbase   
P79269   Detail in HMRbase   
O13186   Detail in HMRbase   
O46567   Detail in HMRbase   
P35547   Detail in HMRbase   
Q95267   Detail in HMRbase   
P49844   Detail in HMRbase   
Q3MSN1   Detail in HMRbase   
Q3MSN4   Detail in HMRbase   
O57353   Detail in HMRbase   
Q28023   Detail in HMRbase   
Q28551   Detail in HMRbase   
Q28890   Detail in HMRbase   
Q28981   Detail in HMRbase   
Q6EDZ0   Detail in HMRbase   
Q6IVJ3   Detail in HMRbase   
Q6QB13   Detail in HMRbase   
Q6RKQ3   Detail in HMRbase   
Q6TN19   Detail in HMRbase   
Q7TSX7   Detail in HMRbase   
Q865Y6   Detail in HMRbase   
Q8JHA4   Detail in HMRbase   
Q8JHA5   Detail in HMRbase   
Q8JJ90   Detail in HMRbase   
Q8JJ91   Detail in HMRbase   
Q8JJ92   Detail in HMRbase   
Q98SJ1   Detail in HMRbase   
Comments!Link to Receptor is not Organism Specific
ReferencesPubchem,HMDB