A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21299 |
| Swiss-prot Accession number | P04150 (Sequence in FASTA format) |
| Description | RecName: Glucocorticoid receptor;GR;Alternative Name: Nuclear receptor subfamily 3 group C member 1; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. |
| Post translational modification | Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser- 203-phosphorylated form is mainly cytoplasmic, and the Ser-211- phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. Sumoylated; this reduces transcription transactivation. Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). |
| Protein Length | 777 Amino acids |
| Molecular weight | 85659 |
| Domain Name | GCR Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2867473 2 PubMed abstract 1707881 3 PubMed abstract 15372022 4 PubMed abstract 15489334 5 PubMed abstract 2026589 6 PubMed abstract 1958537 7 PubMed abstract 3841189 8 PubMed abstract 8358712 9 PubMed abstract 9154805 10 PubMed abstract 9590696 11 PubMed abstract 10477749 12 PubMed abstract 10566686 13 PubMed abstract 10902803 14 PubMed abstract 10866662 15 PubMed abstract 10639135 16 PubMed abstract 11555652 17 PubMed abstract 11238589 18 PubMed abstract 11435610 19 PubMed abstract 12144530 20 PubMed abstract 12000743 21 PubMed abstract 12415108 22 PubMed abstract 15265776 23 PubMed abstract 15211577 24 PubMed abstract 15941832 25 PubMed abstract 16478993 26 PubMed abstract 18691976 27 PubMed abstract 18669648 28 PubMed abstract 12151000 29 PubMed abstract 12686538 30 PubMed abstract 1704018 31 PubMed abstract 8358735 32 PubMed abstract 8445027 33 PubMed abstract 7683692 34 PubMed abstract 8316249 35 PubMed abstract 9150737 36 PubMed abstract 10391209 37 PubMed abstract 10898924 38 PubMed abstract 11589680 39 PubMed abstract 11344238 40 PubMed abstract 11701741 41 PubMed abstract 12351458 42 PubMed abstract 11932321 43 PubMed abstract 12050230 44 PubMed abstract 15276593 45 PubMed abstract 15292341 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 2908 |
| PDB ID | 1M2Z 1NHZ 1P93 3BQD 3CLD |
| Drugpedia | wiki |
| Comments |