Help for using HMRbase

HMRbase is a collection of manually curated Hormones and their receptors. This database basically provide the information about Peptide hormones, Non-peptide hormones and their receptors. Each record of HMRbase for Peptide hormone and receptors is more or less similar but the Non-peptide hormones have different schema. All data in this database is collected after extensive manual literature search and review of other publicly available general databases like SWISSPROT. HMRbase can be searched by keywords, organism name, molecular weight, number of amino acids, log P, water solubility, melting point, PDB ID, KEGG ID, DrugBank ID, HMDB ID etc. This database has been developed by Dr. GPS Raghava's group at Institute of Microbial Technology, New Delhi, INDIA. Each record of HMRbase may contain following information.

Fields for Peptide Hormone and Receptor table

• HMRbase Accession Number:: This is a five digit unique identifier provided to each entry of the Peptide Hormones and Receptors .The entries can be searched from the database by using this unique identifier.

• Swiss-Prot Accession Number:: This contains Swiss-Prot protein entry from which hormone/receptor is formed. On clicking the hyperlink user can directly navigate to the corropsonding Swiss-Prot page.

• Receptor:: This contains the information about the receptor. It is directly hyperlinked to the Swiss-Prot database. On clicking the hyperlink user can directly navigate to the corropsonding Swiss-Prot page. Moreover, an internal link is also there to enter into the corresponding entry page.

• Description:: The field contains the general descriptive information about the hormones/receptors.

• Source Organism:: Source organism specifies is the organism which was the source of the stored sequence

• Taxonomic classification:: Data about taxonomic classification of the source organism. The taxonomic classification is based on EMBL/GenBank/DDBJ nucleotide sequence databases.

• Subcellular localization:: Description of the subcellular location of the mature protein.

• Developmental stage:: It provides information about the development-specific expression of mRNA or protein

• Similarity:: Description of the similaritie(s) (sequence or structural) of a protein with other proteins

• Tissue specificity:: Tissue-specific expression of mRNA or protein. This information may be quite useful in unravelling the localized physiological role about a particular hormone or their receptors.

• Post-translational modification:: Detail of any chemical alternation of a polypeptide (proteolytic cleavage, amino acid modifications etc). It adds functional attribute to a hormone or hormonal receptors.

• Function:: This field contains the information about the function of hormones/receptors. All the information provided in this group are either collected manually by literature search or by Swiss-Prot.

• Protein length:: It provides the total number of amino acids present in the protein.

• Moluecular weight:: It contains the molecular weight. The unit is Dalton.

• References:: It provides the list of work that describes about the property of hormone/receptor. Wherever possible corrosponding PubMed id has also been given. PubMed id is hyperlinked to the NCBI PubMed database. By clicking user can directly go to the NCBI Pubmed abstract.

• Hormone Name:: This column contains the name of active hormone.

• Gene ID:: External link to NCBI's Gene Database.

• PDB ID:: External link to PDB Database.

• Binding Hormone:: This column contains the name of hormone(s) which binds to the receptor that you are viewing.

• Mature Hormone Sequence:: This contains the amino acid sequence of active hormone.

• Position:: Specifies the position of active hormone in full length protein.

• Receptor:: Lists the name of receptor(s) to which hormone binds.

• Domain:: A structurally and functionally defined protein region. In proteins with multiple domains, the combination of the domains determines the function of the protein. A Pfam domain search facility is incorporated into "hmrbase".

  Fields for Non-peptide Hormone Table

• ID:: This is a four digit number, unique identifier for all the entries present in Non-peptide Hormone database.

• PubChem ID:: Link to NCBI's PubChem database.

• Name:: This is the name of Non-peptide hormone to which all the given information belongs.

• Molecular weight:: Molecular weight of given Non-peptide hormone.

• Molecular formula:: Molecular formula of given Non-peptide hormone.

• IUPAC Name:: IUPAC name of given Non-peptide hormone.

• Canonical SMILE:: Canonical SMILE of given Non-peptide hormone.

• Isomeric SMILE:: Isomeric SMILE of given Non-peptide hormone.

• Structure:: This 2-D & 3-D structure visualization tool.By right click in 3D structure visualization tool window you can generate the vander wall surface area,molecular surface area and other command that used in jmol.

• PDB file:: You can download PDB file of Non-peptide hormone here.

• SDF file:: You can download SDF file of Non-peptide hormone here.

• MOL file:: You can download MOL file of Non-peptide hormone here.

• PDB ID:: External link to RCSB database.

• KEGG ID:: External link to KEGG database.

• HMDB ID:: External link to Human Metabolome database.

• Melting Point:: Melting point experimental as well as predicted in degree celcious.

• Log P:: Log P experimental as well as predicted.

• Water Solubility:: Water solubility experimental as well as predicted at a particular temperature.

• DrugBank ID:: Exteranl link to DrugBank database.

• Drugpedia:: External link to Drugpedia where lot of information about hormones and their receptors is available. User can also add new and valuable information about the hormones and their receptors.

• Receptor:: Link to receptor to which a particular Non-peptide hormone binds.

• Comment:: Any comments about receptor or Hormone in an entry.