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The total number entries retrieved from this search are 178
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Note: Potential Biomarker with * indicates these signatures are candidate biomarkers extracted from experiments on mice, rat or cell lines and they are not validated on human patients'cohort.
Biomarker IDBiomarkerBiomoleculeSubjectRegulationBiomarker's typeExperimentLevel of significanceSourcePMID
2278Cyclophilin B (Peptidyl-prolyl cis-trans isomerase B)ProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.53) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2279ORP150ProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.59) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2280VinculinProteinHumanUpregulated in recurrence HCC than non-recurrence HCC (with fold change 1.82) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2281Flavin reductaseProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.52) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2282StathminProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.56) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2283Protein kinase C inhibitor protein-1ProteinHumanUpregulated in recurrence HCC than non-recurrence HCC (with fold change 2.7) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2284Heterogeneous nuclear ribonucleoprotein A2/B1ProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.55) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
228526S proteasome non-ATPase regulatory subunit 8ProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.64) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2286Glutamine amidotransferaseProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.69) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2287Phosphoglycerate kinase 1ProteinHumanUpregulated in recurrence HCC than non-recurrence HCC (with fold change 1.57) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2288TCP-1 chaperonin cofactor AProteinHumanUpregulated in recurrence HCC than non-recurrence HCC (with fold change 1.57) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2289TCP-1-gammaProteinHumanDownregulated in recurrence HCC than non-recurrence HCC (with fold change 0.64) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2290Multidrug resistance-associ ated protein MGr1-AgProteinHumanUpregulated in recurrence HCC than non-recurrence HCC (with fold change 1.51) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2291Nuclear chloride ion channel 27ProteinHumanUpregulated in recurrence HCC than non-recurrence HCC (with fold change 1.64) PrognosticEarly recurrence v/s No recurrence HCC p < 0.05Tissue17391314
2317NDRG2Protein and RNAsHumanDownregulated in HCC than non-tumor Diagnostic and PrognosticHCC v/s cirrhosis/healthy/non-tumor HCC; associated with recurrence and tumor grade p < 0.05Tissue18519680
2318CSTBProtein and RNAsHumanUpegulated in HCC than non-tumor DiagnosticHCC v/s cirrhosis/healthy/non-tumor HCC p < 0.05Serum18281540
2319AFPProteinHumanUpegulated in HCC than non-tumor DiagnosticHCC v/s cirrhosis/healthy/non-tumor HCC p < 0.05Serum18281540
2320CSTB, AFPProteinHumanUpegulated in HCC than non-tumor DiagnosticHCC v/s cirrhosis/healthy/non-tumor HCC p < 0.05Serum18281540
2324ID2Protein and RNAsHumanDownregulated in HCCs with PVI in comparison with HCCs without PVI (with Fisher ratio 1.4) PrognosticHCC with PVI v/s HCC without PVI p < 0.005Tissue17088983
2359RhoCProtein and RNAHumanUpregulated in highly invasive NHCC than in less invasive SLHCC and upregulated in EHML (Extrahepatic Metastatic Lesions) than HCC and PCLT (Pericarcinomatous liver tissues). PrognosticEHML (Extrahepatic Metastatic Lesions) v/s HCC and PCLT(pericarcinomatous liver tissues); increased RhoC expression strongly correlates with vein invasion p < 0.01Tissue15150600
2419IGF2ProteinHumanUpregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2420ADAM9ProteinHumanUpregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2421STAT3ProteinHumanUpregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2422SOCS3ProteinHumanUpregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2423cyclin D1ProteinHumanUpregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2424COL1A1ProteinHumanDownregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2425SMAD4ProteinHumanDownregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2426FHITProteinHumanDownregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2427SOCS1ProteinHumanDownregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2428IGFBP7Protein and RNAsHumanDownregulated in IFN-resistant cells (with fold change 2.963) PredictiveIGFBP7-positive HCC patients v/s IGFBP7-negative HCC patients p < 0.05Cell line and Tissue20407444
2467GRP94, GRP78, GRP75, HSC71, HSP90, HSP70, HSP60, Aconitase, EF-2, Nucleophosmin, VIM, NDK-A, Argininosuccinate synthase, CPSASE-I,ProteinHumanDifferentially expressed (Argininosuccinate synthase, Carbamoyl-phosphate synthase (CPSASE I) are Downregulated and rest 12 are Upregulated) in HCC tumor v/s non-tumorous DiagnosticHCC tumor v/s non-tumorous p < 0.05Tissue14654528
2468hnRNP K, HSP70RY, Lamin B1, 40S ribosomal protein SA, FTCD, SOD, Arginase, SMP-30, P5C dehydrogenase, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Thiosulfate sulfurtransferase (Rhodanese), Betaine-himocysteine S-methyltransferase, NCC27, FGB, RACK1, PDI, SARDHProteinHumanDifferentially expressed (hnRNP K, HSP70 RY, Lamin B1, 40S ribosomal protein SA, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Rhodanese, Betaine-himocysteine S-methyltransferase, NCC27, Fibrinogen β chain, RACK1 are Upregulated and rest 12 are Downregulated) DiagnosticHBV associated HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2469GABA-AT, Cytosol aminopepsidase, AFB1-AR2, Acyl-CoA dehydrogenase, GDH,ProteinHumanDifferentially expressed (GABA-AT, AFB1-AR2) are Upregulated and rest 3 are Downregulated) in HCC tumor v/s non-tumorous DiagnosticHCV associated HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2470HSP27, Enoyl-CoA hydratase, Tubulin β chain, Galactose kinase, Ubiquinol-cytochrome C reductase complex core protein I, Annexin V, P-PST, Ribosome binding protein, Fumarylacetoacetase, ALDH, Catalase,ProteinHumanDifferentially expressed (P-PST, Ribosome binding protein, Fumarylacetoacetase, Catalase and ALDH are Downregulated and rest 6 are Upregulated) in HCC tumor v/s non-tumorous DiagnosticBoth HBV- and HCV associated HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2471Protein disulfide isomerase ER-60, PRBP, Tropomyosin 3, ATP synthase, Dihydropipoamide dehydrogenase, FABP, Cathepsin B1,ProteinHumanDifferentially expressed (FABP, Cathepsin B1 are Downregulated and rest 5 are Upregulated) in HCC tumor v/s non-tumorous Diagnosticboth (HBV and HCV) negative HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2472AURKBProtein and RNAsHumanUpregulated in HCC tissues in association with aggressive recurrence v/s non-recurrence PrognosticAggressive recurrence HCC v/s non-recurrence HCC p < 0.001Tissue18311747
2473hnRNP C1/C2ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2474Hcp70/Hsp90-organizing protein (HOP)ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2475GRP-78ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2476heat shock 70-kDa protein 1ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2477heat shock 70-kDa protein 4ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2478T-complex protein 1ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2479MATProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2480GNMTProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2481BHMTProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2482COMTProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2487Protein disulfide isomerase A3ProteinHumanUpregulated in HCC than non tumor (with mean ratio of 4.3 +/- 3.7) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2488Heat shock 27 kDa proteinProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 8.4 +/- 5.8) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2489Glycerol-3-phosphate dehydrogenaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 9.9 +/- 9.6) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2490Senescence marker protein-30ProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 7.9 +/- 11.1) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271

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