| Detailed information |
|---|
| CancerLivER ID | 2319 |
| Biomarker | AFP |
| Biomarker Name/Symbol (given in Publication) | AFP |
| Biomolecule | Protein |
| Subject | Human |
| Degree of Validity | CSTB and AFP in combination might be a potential marker for diagnosing HCC and validated on independent dataset |
| Experimental Condition | HCC v/s cirrhosis/healthy/non-tumor HCC |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Upegulated in HCC than non-tumor |
| Level of significance | p < 0.05 |
| Source | Serum |
| PMID | 18281540 |
| Type of Biomarker | Diagnostic |
| Pathway | Glucocorticoid receptor regulatory network and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers |
| Cohort | Normal healthy subjects (group 1, n = 52) and patients with noncirrhotic chronic hepatitis (group 2, n = 53), cirrhosis (group 3, n = 43), and HCC (group 4, n = 62); HCC cell lines, including HepG2, Hep3B, PLC/PRF/5, Huh7, and SK-HEP-1 cells, and immortalized epithelial cell lines, such as THLE-3 an |
| Sensitivity | 72.60% |
| Specificity | 76.00% |
| Accuracy | NA |
| AUC | 0.802 |
| Disease | HCC v/s cirrhosis/healthy/non-tumor HCC |
| Year of Publication | 2008 |
| Clinical trial | YES |
| NCT No# (Clinical trial) | NCT00005629,NCT03132792,NCT00513461,NCT00093548,NCT01350167,NCT02435433,NCT02072356,NCT02582918,NCT02232490,NCT01128803,NCT02312817,NCT01849588,NCT03156582,NCT03533582,NCT03767764,NCT01078311,NCT03493763,NCT00980460,NCT00629421,NCT01392131,NCT0174764 |