CancerLivER: Biomarker Card

Biomarker Card: Comprehensive information about a biomarker


Biomarker ID 2419
Detailed information
CancerLivER ID2419
Biomarker IGF2
Biomarker Name/Symbol (given in Publication)IGF (insulin growth factor) II
BiomoleculeProtein
SubjectHuman
Degree of ValidityPotenial Diagnostic marker for HCC; but not validated on independent patient cohort
Experimental ConditionHCC v/s normal
Cancer typeHepatocellular carcinoma
RegulationUpregulated in HCC than normal
Level of significance (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)
SourceTissue
PMID14517841
Type of BiomarkerDiagnostic
Pathwaygrowth factor activity and insulin receptor binding
Cohort210 HCC specimens and corresponding liver tissue: 108 patients had concomitant liver cirrhosis (51%) due to HBV infection (n = 29), HCV infection (n = 23), alcohol consumption (n = 39), autoimmune disorders (n = 10), haemochromatosis (n = 2), or other (unknown) reasons (n = 5); 30 HCC patients witho
SensitivityNA
SpecificityNA
AccuracyNA
AUCNA
DiseaseHCC v/s normal liver
Year of Publication2003
Clinical trialYES
NCT No# (Clinical trial) NCT01498952,NCT00495846

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