Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2632Soluble factors

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NANANANANaturalnduction of the IL-ÔôÄ promoterToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NAHela cell linesLeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2632Soluble factors

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NANANANANaturalnduction of the IL-ÔôÄ promoterToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NAHela cell linesLeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2634ssRNA40/LyoVec

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NANANANASyntheticanti- inflammatory activityToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA291137972017Pubchem_assay
PRRID_2634ssRNA40/LyoVec

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NANANANASyntheticanti- inflammatory activityToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA291137972017Pubchem_assay
PRRID_2637sulfoglycolipids

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Mycobacterium tuberculosis (Bacteria)CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCCNAPattern-associated molecular patterns (PAMPs)NaturalTuberculosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784inhibit NF-κB activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonistsTLR2 Binding assay289739282017Pubchem_assay
PRRID_2637sulfoglycolipids

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Mycobacterium tuberculosis (Bacteria)CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCCNAPattern-associated molecular patterns (PAMPs)NaturalTuberculosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784inhibit NF-κB activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonistsTLR2 Binding assay289739282017Pubchem_assay
PRRID_2638synthetic dsRNA

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2638synthetic dsRNA

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2644Taxol

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NACC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)NaturalEnhancement of dendritic cell maturation and alloreactive T-cell responses, Upregulate mRNA expressions of MCP-Ôõú, TNF- a, induction of proinflammatory cytokines, accelerate podocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2644Taxol

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NACC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)NaturalEnhancement of dendritic cell maturation and alloreactive T-cell responses, Upregulate mRNA expressions of MCP-Ôõú, TNF- a, induction of proinflammatory cytokines, accelerate podocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2649Tenascin C

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ECM glycoprotein(others)MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS2201Damage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2649Tenascin C

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ECM glycoprotein(others)MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS2201Damage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2652TLR 2 ligand

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NANANANANaturalEnhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAEToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surface and in the cytoplasm of bronchiolar epithelial cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2652TLR 2 ligand

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NANANANANaturalEnhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAEToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surface and in the cytoplasm of bronchiolar epithelial cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2653TLR 2 ligand

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NANANANANaturalEnhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAEToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanapical membrane of murine small IECsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2653TLR 2 ligand

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NANANANANaturalEnhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAEToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanapical membrane of murine small IECsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2654TLR4 ligand

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NANANANANaturalEnhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAEToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surface and in the cytoplasm of bronchiolar epithelial cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2654TLR4 ligand

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NANANANANaturalEnhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAEToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surface and in the cytoplasm of bronchiolar epithelial cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2655TMX-20x

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NANANAPhospholipidSyntheticcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanhTLR7 CellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NADLS, EPR and cytotoxicity assessment292003062017Pubchem_assay
PRRID_2655TMX-20x

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NANANAPhospholipidSyntheticcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanhTLR7 CellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NADLS, EPR and cytotoxicity assessment292003062017Pubchem_assay
PRRID_2656TMX-30x

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NANANA1V209-PEGSyntheticcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanhTLR7 CellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA292003062017Pubchem_assay
PRRID_2656TMX-30x

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NANANA1V209-PEGSyntheticcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanhTLR7 CellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA292003062017Pubchem_assay
PRRID_2658Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA292639322017Pubchem_assay
PRRID_2658Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA292639322017Pubchem_assay
PRRID_2659Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2659Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2660Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalInduce IL-Ôòæ production in human tonsillar B cellsToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA290283692017Pubchem_assay
PRRID_2660Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalInduce IL-Ôòæ production in human tonsillar B cellsToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA290283692017Pubchem_assay
PRRID_2661Unknown

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BacteriaNANAProteinNaturalNATRl OToll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2661Unknown

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BacteriaNANAProteinNaturalNATRl OToll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2662Unknown (uropathogenic bacteria)

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BacteriaNANAProteinNaturalNAToll-like receptor (TLRll)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2662Unknown (uropathogenic bacteria)

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BacteriaNANAProteinNaturalNAToll-like receptor (TLRll)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2663Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA292639322017Pubchem_assay
PRRID_2663Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA292639322017Pubchem_assay
PRRID_2664Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNANAQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2664Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNANAQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2665Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2665Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2666Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2666Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2667Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2667Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2668Unmethylated CpG DNA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2668Unmethylated CpG DNA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2669Unmethylated CpG DNA

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BacteriaNANAProteinNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2669Unmethylated CpG DNA

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BacteriaNANAProteinNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2676Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9QUK7511NANA289610192017Pubchem_assay
PRRID_2676Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9QUK7511NANA289610192017Pubchem_assay
PRRID_2677Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2677Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2678Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2678Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2679Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.NAToll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2679Uric acid

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NAC12=C(NC(=O)N1)NC(=O)NC2=ONADamage-associated molecular patterns (DAMPs)NaturalInduce the synthesis of IL-1, IL-6, IL-8, TNF-α, TXA2 and PGE2 by human monocytes.NAToll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2680Uropathogenic E. coli

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E. coli(Bacteria)NANANANaturalNAToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292639322017NA
PRRID_2680Uropathogenic E. coli

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E. coli(Bacteria)NANANANaturalNAToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292639322017NA
PRRID_2683Versican

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Proteoglycan (others)COP(=O)(OC)OC=C(Cl)ClNAproteoglycanNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2683Versican

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Proteoglycan (others)COP(=O)(OC)OC=C(Cl)ClNAproteoglycanNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2684Versican

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Proteoglycan (others)COP(=O)(OC)OC=C(Cl)ClNAproteoglycanNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2684Versican

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Proteoglycan (others)COP(=O)(OC)OC=C(Cl)ClNAproteoglycanNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2693Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA292639322017Pubchem_assay
PRRID_2693Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA292639322017Pubchem_assay
PRRID_2694Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA292639322017Pubchem_assay
PRRID_2694Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA292639322017Pubchem_assay
PRRID_2695Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA292639322017Pubchem_assay
PRRID_2695Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA292639322017Pubchem_assay
PRRID_2696Zymosan

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Fungi(Yeast)NANAGlucanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2696Zymosan

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Fungi(Yeast)NANAGlucanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2701CBLB502

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NANANANASyntheticalleviate bone marrow and intestinal injuriesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293644992018Pubchem_assay
PRRID_2701CBLB502

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NANANANASyntheticalleviate bone marrow and intestinal injuriesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293644992018Pubchem_assay
PRRID_2702CBLB502

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NANANANASyntheticalleviate bone marrow and intestinal injuriesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)rhesus monkeyNALeucine-rich Repeat (LRR) DomainNANANANANA293644992018NA
PRRID_2702CBLB502

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NANANANASyntheticalleviate bone marrow and intestinal injuriesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)rhesus monkeyNALeucine-rich Repeat (LRR) DomainNANANANANA293644992018NA
PRRID_2731polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor (TLR19)Toll-like receptor (TLR)Grass Carp (Ctenopharyngodon idella)internal membrane.LRR,TIR domainNANANANALuciferase assay292296762018NA
PRRID_2731polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor (TLR19)Toll-like receptor (TLR)Grass Carp (Ctenopharyngodon idella)internal membrane.LRR,TIR domainNANANANALuciferase assay292296762018NA