Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_2531	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	NA	Synthetic	anti- inflammatory activity	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29113797	2017	NA
PRRID_2531	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	NA	Synthetic	anti- inflammatory activity	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29113797	2017	NA
PRRID_2534	PBP2 Click for more detail	NA	NA	NA	NA	Natural	Dendritic cell maturation	Toll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBP	Toll-like receptor (TLR)	NA	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28334203	2017	NA
PRRID_2534	PBP2 Click for more detail	NA	NA	NA	NA	Natural	Dendritic cell maturation	Toll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBP	Toll-like receptor (TLR)	NA	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28334203	2017	NA
PRRID_2535	PEDV S-INDEL Click for more detail	Virus	NA	NA	NA	Natural	enteric disease	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	neonatal pigs	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NF-Œ∫B activation	Antibacterial activity assay	29249266	2017	NA
PRRID_2535	PEDV S-INDEL Click for more detail	Virus	NA	NA	NA	Natural	enteric disease	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	neonatal pigs	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NF-Œ∫B activation	Antibacterial activity assay	29249266	2017	NA
PRRID_2536	PEDV S-INDEL Click for more detail	Virus	NA	NA	NA	Natural	enteric disease	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	neonatal pigs	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NF-Œ∫B activation	Antibacterial activity assay	29249266	2017	NA
PRRID_2536	PEDV S-INDEL Click for more detail	Virus	NA	NA	NA	Natural	enteric disease	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	neonatal pigs	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NF-Œ∫B activation	Antibacterial activity assay	29249266	2017	NA
PRRID_2537	PEDV S-INDEL Click for more detail	Virus	NA	NA	NA	Natural	enteric disease	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	neonatal pigs	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NF-Œ∫B activation	Antibacterial activity assay	29249266	2017	NA
PRRID_2537	PEDV S-INDEL Click for more detail	Virus	NA	NA	NA	Natural	enteric disease	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	neonatal pigs	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NF-Œ∫B activation	Antibacterial activity assay	29249266	2017	NA
PRRID_2538	Peptidoglycan (PG) (Legionella recognized) Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2538	Peptidoglycan (PG) (Legionella recognized) Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2540	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Increased gene expression and secretion of proinflammatory cytokines (IL-Ôòæ) and chemokines (IL-ÔôÄ),Activate macrophages and produce inflammatory responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2540	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Increased gene expression and secretion of proinflammatory cytokines (IL-Ôòæ) and chemokines (IL-ÔôÄ),Activate macrophages and produce inflammatory responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2548	IRS 945 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29039348	2017	Pubchem_assay
PRRID_2548	IRS 945 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29039348	2017	Pubchem_assay
PRRID_2550	periplasmic flagella Click for more detail	T. denticola (Bacteria)	MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ	349	Pattern-associated molecular patterns (PAMPs)	Natural	periodontal inflammation;	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29084899	2017	Pubchem_assay
PRRID_2550	periplasmic flagella Click for more detail	T. denticola (Bacteria)	MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ	349	Pattern-associated molecular patterns (PAMPs)	Natural	periodontal inflammation;	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29084899	2017	Pubchem_assay
PRRID_2552	phosphatidyl-myo-inositol mannosides (PIM) Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	THP‚Äê1 macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	Pubchem_assay
PRRID_2552	phosphatidyl-myo-inositol mannosides (PIM) Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	THP‚Äê1 macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	Pubchem_assay
PRRID_2554	Phospholipomannan Click for more detail	NA	NA	NA	NA	Natural	induce cardiomyocyte inflammation, activate NF-Œ∫B, and up-regulate the expression of pro-inflammatory cytokines in human monocytes in a CDÔõúÔòº-dependent fashion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human keratinocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2554	Phospholipomannan Click for more detail	NA	NA	NA	NA	Natural	induce cardiomyocyte inflammation, activate NF-Œ∫B, and up-regulate the expression of pro-inflammatory cytokines in human monocytes in a CDÔõúÔòº-dependent fashion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human keratinocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2557	poli I/C, resveratrol Click for more detail	NA	NA	NA	NA	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	ELISA	29039348	2017	Pubchem_assay
PRRID_2557	poli I/C, resveratrol Click for more detail	NA	NA	NA	NA	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	ELISA	29039348	2017	Pubchem_assay
PRRID_2559	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29353310	2017	Pubchem_assay
PRRID_2559	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29353310	2017	Pubchem_assay
PRRID_2562	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	anti- inflammatory activity	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29113797	2017	Pubchem_assay
PRRID_2562	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	anti- inflammatory activity	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29113797	2017	Pubchem_assay
PRRID_2567	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	tbToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Scophthalmus maximus	Liver and spleen	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	ELISA	28495564	2017	NA
PRRID_2567	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	tbToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Scophthalmus maximus	Liver and spleen	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	ELISA	28495564	2017	NA
PRRID_2568	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2568	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2569	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2569	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2570	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	CcToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Cyprinus carpio L	All tested tissue	A signal peptide, 16 LRR domains, a LRRCT domain in the extracellular region and a TIR domain.	NA	NA	NA	activate NF-Œ∫B.	RT-qPCR	28192255	2017	NA
PRRID_2570	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	CcToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Cyprinus carpio L	All tested tissue	A signal peptide, 16 LRR domains, a LRRCT domain in the extracellular region and a TIR domain.	NA	NA	NA	activate NF-Œ∫B.	RT-qPCR	28192255	2017	NA
PRRID_2572	Polysaccharide fragments of heparan sulfate Click for more detail	NA	CO[C@@H]1[C@H]([C@@H]([C@@H](O[C@@H]1C(=O)[O-])O[C@H]2[C@@H](O[C@H]([C@H]([C@@H]2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	NA	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	29028369	2017	Pubchem_assay
PRRID_2572	Polysaccharide fragments of heparan sulfate Click for more detail	NA	CO[C@@H]1[C@H]([C@@H]([C@@H](O[C@@H]1C(=O)[O-])O[C@H]2[C@@H](O[C@H]([C@H]([C@@H]2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	NA	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	29028369	2017	Pubchem_assay
PRRID_2573	Porin PorB Click for more detail	NA	NA	NA	NA	Natural	Induce TLRÔõú signaling after binding to TLRÔò∫	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29028369	2017	Pubchem_assay
PRRID_2573	Porin PorB Click for more detail	NA	NA	NA	NA	Natural	Induce TLRÔõú signaling after binding to TLRÔò∫	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29028369	2017	Pubchem_assay
PRRID_2574	Porins Click for more detail	NA	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	NA	Natural	Cell activation, induce NFŒ∫B activation, Induction of the IL-ÔôÄ promoter	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2574	Porins Click for more detail	NA	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	NA	Natural	Cell activation, induce NFŒ∫B activation, Induction of the IL-ÔôÄ promoter	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2575	potassium peroxychromate (PPC) Click for more detail	NA	NA	NA	Reactive oxygen species (ROS)	Synthetic	PPC decomposition can release several oxygen- centered free radicals such as superoxide anion and hydroxyl radicals	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	RAW-Blue cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	RT-PCR and Western blot,	29175419	2017	Pubchem_assay
PRRID_2575	potassium peroxychromate (PPC) Click for more detail	NA	NA	NA	Reactive oxygen species (ROS)	Synthetic	PPC decomposition can release several oxygen- centered free radicals such as superoxide anion and hydroxyl radicals	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	RAW-Blue cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	RT-PCR and Western blot,	29175419	2017	Pubchem_assay
PRRID_2576	Profilin and bacterial rRNA respectively (not found in humans) Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Toll-like receptor 12 (TLR12)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2576	Profilin and bacterial rRNA respectively (not found in humans) Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Toll-like receptor 12 (TLR12)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2577	Profilin and bacterial rRNA respectively (not found in humans) Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2577	Profilin and bacterial rRNA respectively (not found in humans) Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2578	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	NA	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29263932	2017	NA
PRRID_2578	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	NA	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29263932	2017	NA
PRRID_2580	R837 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes. Innate immune cells except neutrophils and pDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2580	R837 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes. Innate immune cells except neutrophils and pDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2581	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2581	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2582	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2582	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2583	rb-dsRNA Click for more detail	Rice- bran (plant)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	activate caspase 1 via TRIF, resulting in the release of IL-1b and LDH	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasome	RT-qPCR	28848065	2017	Pubchem_assay
PRRID_2583	rb-dsRNA Click for more detail	Rice- bran (plant)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	activate caspase 1 via TRIF, resulting in the release of IL-1b and LDH	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasome	RT-qPCR	28848065	2017	Pubchem_assay
PRRID_2585	rBanLec Click for more detail	E. coli(Bacteria)	NA	NA	NA	Synthetic	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Peritoneal macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	production of TNFŒ± and NO in BALB/c macrophages.	ELISA	28235050	2017	Pubchem_assay
PRRID_2585	rBanLec Click for more detail	E. coli(Bacteria)	NA	NA	NA	Synthetic	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Peritoneal macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	production of TNFŒ± and NO in BALB/c macrophages.	ELISA	28235050	2017	Pubchem_assay
PRRID_2589	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	NA	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29049886	2017	NA
PRRID_2589	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	NA	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29049886	2017	NA
PRRID_2590	RNA Click for more detail	Streptococcus (Bacteria)	NA	NA	NA	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	23S rRNA motif,	Q9NR97.fasta	Q9NR97	1041	NA	NA	29042860	2017	Pubchem_assay
PRRID_2590	RNA Click for more detail	Streptococcus (Bacteria)	NA	NA	NA	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	23S rRNA motif,	Q9NR97.fasta	Q9NR97	1041	NA	NA	29042860	2017	Pubchem_assay
PRRID_2591	RNA Click for more detail	Type B coxsackieviruses (CVBs) (others)	NA	NA	Nucleic Acid	Natural	myocarditis and acute pancreatitis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	NA	NA	28973047	2017	Pubchem_assay
PRRID_2591	RNA Click for more detail	Type B coxsackieviruses (CVBs) (others)	NA	NA	Nucleic Acid	Natural	myocarditis and acute pancreatitis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	NA	NA	28973047	2017	Pubchem_assay
PRRID_2592	RNA Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2592	RNA Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2593	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q99MB1.fasta	Q99MB1	905	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2593	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q99MB1.fasta	Q99MB1	905	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2594	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	P58681.fasta	P58681	1050	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2594	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	P58681.fasta	P58681	1050	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2601	S100 proteins Click for more detail	Cytosol(others)	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2601	S100 proteins Click for more detail	Cytosol(others)	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2603	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2603	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2604	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2604	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2615	SIN-1 Click for more detail	NA	NA	NA	Reactive oxygen species (ROS)	Synthetic	SIN-1 produces cell permeable peroxynitrite anions that can react with lipids, DNA and proteins by direct oxidative reaction or by indirect radical-induced mechanisms	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	RAW-Blue cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	RT-PCR and Western blot,	29175419	2017	Pubchem_assay
PRRID_2615	SIN-1 Click for more detail	NA	NA	NA	Reactive oxygen species (ROS)	Synthetic	SIN-1 produces cell permeable peroxynitrite anions that can react with lipids, DNA and proteins by direct oxidative reaction or by indirect radical-induced mechanisms	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	RAW-Blue cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	RT-PCR and Western blot,	29175419	2017	Pubchem_assay
PRRID_2617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29066255	2017	Pubchem_assay
PRRID_2617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29066255	2017	Pubchem_assay
PRRID_2618	single-stranded RNA Click for more detail	exogenous viruses (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	cellular endosomal compartments,	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2618	single-stranded RNA Click for more detail	exogenous viruses (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	cellular endosomal compartments,	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2619	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	29038956	2017	Pubchem_assay
PRRID_2619	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	29038956	2017	Pubchem_assay
PRRID_2620	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	NA	NA	29038956	2017	Pubchem_assay
PRRID_2620	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	NA	NA	29038956	2017	Pubchem_assay
PRRID_2621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Induce production of inflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	airway and lung epithelial Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29028369	2017	Pubchem_assay
PRRID_2621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Induce production of inflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	airway and lung epithelial Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29028369	2017	Pubchem_assay
PRRID_2622	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29028369	2017	Pubchem_assay
PRRID_2622	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29028369	2017	Pubchem_assay
PRRID_2627	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2627	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2628	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2628	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2629	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2629	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2630	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2630	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA

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