Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2291Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Human(hippocampus, entorhinal cortex, superior frontal gyrus, post-central gyrus)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784mRNA ‚Üë in aging and ADNA288015212017Pubchem_assay
PRRID_2291Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Human(hippocampus, entorhinal cortex, superior frontal gyrus, post-central gyrus)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784mRNA ‚Üë in aging and ADNA288015212017Pubchem_assay
PRRID_2292Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Rathippocampus (microglia)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784mRNA ‚Üë in postoperative cognitive dysfunction in senile animalsNA288015212017Pubchem_assay
PRRID_2292Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Rathippocampus (microglia)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784mRNA ‚Üë in postoperative cognitive dysfunction in senile animalsNA288015212017Pubchem_assay
PRRID_2293Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2293Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2294Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanBrain(neurons)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784protein ‚Üë in PDNA288015212017Pubchem_assay
PRRID_2294Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanBrain(neurons)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784protein ‚Üë in PDNA288015212017Pubchem_assay
PRRID_2295Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Ratbrain (vasculature)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784protein ‚Üë, activation in ischemic strokeNA288015212017Pubchem_assay
PRRID_2295Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Ratbrain (vasculature)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784protein ‚Üë, activation in ischemic strokeNA288015212017Pubchem_assay
PRRID_2296Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNeurons(cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2296Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNeurons(cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2297Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNFκB activation and cytokine productionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman embryonic kidney 293 (HERK 293 ) cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_2297Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNFκB activation and cytokine productionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman embryonic kidney 293 (HERK 293 ) cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_2306LMW-HA

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Glycosaminoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANANANA292901392017NA
PRRID_2306LMW-HA

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Glycosaminoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANANANA292901392017NA
PRRID_2307LMW-HA

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Glycosaminoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANANANA292901392017NA
PRRID_2307LMW-HA

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Glycosaminoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANANANA292901392017NA
PRRID_2311Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2311Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2314Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2314Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2315Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2315Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2316polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2316polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2317Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2317Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2318Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2318Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2319polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2319polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2320Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2320Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2323Mannan

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Fungi(Yeast)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalActivate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2323Mannan

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Fungi(Yeast)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalActivate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2324Mannan

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Fungi(Yeast)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalActivate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290283692017Pubchem_assay
PRRID_2324Mannan

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Fungi(Yeast)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalActivate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290283692017Pubchem_assay
PRRID_2342methanol extract

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C.atratum(others)NANANANaturalanti- inflammatory activity against mastitisToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemammary tissueLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835LPS from Gram-negative bacteria (Miyake et al., 2002). LPS activates the TLR4-mediated signal pathway and leads to the activation of NF-κB, MAPKs to regulate the release of pro-inflammatory cytokines.NA291138062017Pubchem_assay
PRRID_2342methanol extract

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C.atratum(others)NANANANaturalanti- inflammatory activity against mastitisToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemammary tissueLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835LPS from Gram-negative bacteria (Miyake et al., 2002). LPS activates the TLR4-mediated signal pathway and leads to the activation of NF-κB, MAPKs to regulate the release of pro-inflammatory cytokines.NA291138062017Pubchem_assay
PRRID_2344Microfilarial protein (MfP)

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W. bancrofti (others)NANAPattern-associated molecular patterns (PAMPs)Naturalbinds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NF-κB activation that up-regulates secretion of proinflammatory cytokines.co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis.284538502017Pubchem_assay
PRRID_2344Microfilarial protein (MfP)

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W. bancrofti (others)NANAPattern-associated molecular patterns (PAMPs)Naturalbinds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NF-κB activation that up-regulates secretion of proinflammatory cytokines.co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis.284538502017Pubchem_assay
PRRID_2347mt-DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanGranulocytes and monocytesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154release of interferon type 1 and TNF-a through the activation of IL-1R-associated kinase 1, 2, and 4 and the phosphorylation of p38 MAPKNA280491422017Pubchem_assay
PRRID_2347mt-DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanGranulocytes and monocytesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154release of interferon type 1 and TNF-a through the activation of IL-1R-associated kinase 1, 2, and 4 and the phosphorylation of p38 MAPKNA280491422017Pubchem_assay
PRRID_2348mt-DNA

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Mitochondria (others)NANANucleic AcidNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA292901392017Pubchem_assay
PRRID_2348mt-DNA

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Mitochondria (others)NANANucleic AcidNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA292901392017Pubchem_assay
PRRID_2354Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2354Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2355polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2355polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracoisolated peripheral blood lymphocytesLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2356Mycoplasma

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Pathogens (others)NANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2356Mycoplasma

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Pathogens (others)NANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2357Mycotoxin

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FungiNANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation btTOLLBtTollToll-like receptor (TLR)NA3rd nymphal instar.TIR domainNANANAmicrobe detection, AMPs production, phagosome regulations, inflammatory signaling and activationqRT-PCR286489962017NA
PRRID_2357Mycotoxin

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FungiNANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation btTOLLBtTollToll-like receptor (TLR)NA3rd nymphal instar.TIR domainNANANAmicrobe detection, AMPs production, phagosome regulations, inflammatory signaling and activationqRT-PCR286489962017NA
PRRID_2358Myosin

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Cytosol, endosome(others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2358Myosin

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Cytosol, endosome(others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2359Myosin

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Cytosol, endosome(others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2359Myosin

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Cytosol, endosome(others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2363NA

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H. pylori (Bacteria)NANANANAH. pylori infection.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanthe apical and the basolateral pole of the gastric epitheliumLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2363NA

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H. pylori (Bacteria)NANANANAH. pylori infection.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanthe apical and the basolateral pole of the gastric epitheliumLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2364NA

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H. pylori (Bacteria)NANANANAH. pylori infection.Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanapical and basolateral surface in adult non-inflamed gastric epithelial cells but these receptors were localized exclusively to the basolateral surface in adults with H. pylori gastritisLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2364NA

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H. pylori (Bacteria)NANANANAH. pylori infection.Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanapical and basolateral surface in adult non-inflamed gastric epithelial cells but these receptors were localized exclusively to the basolateral surface in adults with H. pylori gastritisLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2365NA

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H. pylori (Bacteria)NANANANAH. pylori infection.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanapical and basolateral surface in adult non-inflamed gastric epithelial cells but these receptors were localized exclusively to the basolateral surface in adults with H. pylori gastritisLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2365NA

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H. pylori (Bacteria)NANANANAH. pylori infection.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanapical and basolateral surface in adult non-inflamed gastric epithelial cells but these receptors were localized exclusively to the basolateral surface in adults with H. pylori gastritisLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2366NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2366NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2367NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2367NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2368NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basal poles of mu- rine crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032cells responded with increased mitogenic activity and cytokine productionNA293306752017Pubchem_assay
PRRID_2368NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basal poles of mu- rine crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032cells responded with increased mitogenic activity and cytokine productionNA293306752017Pubchem_assay
PRRID_2369NA

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NANANANANANAToll-like receptor 2 (TLR2) Toll-like receptor (TLR)presuckling pigletscytoplasm and on the apical surface of intes- tinal M cellsLeucine-rich Repeat (LRR) DomainNANANANANA293306752017NA
PRRID_2369NA

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NANANANANANAToll-like receptor 2 (TLR2) Toll-like receptor (TLR)presuckling pigletscytoplasm and on the apical surface of intes- tinal M cellsLeucine-rich Repeat (LRR) DomainNANANANANA293306752017NA
PRRID_2370NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)presuckling pigletscytoplasm and on the apical surface of intes- tinal M cellsLeucine-rich Repeat (LRR) DomainNANANANANA293306752017NA
PRRID_2370NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)presuckling pigletscytoplasm and on the apical surface of intes- tinal M cellsLeucine-rich Repeat (LRR) DomainNANANANANA293306752017NA
PRRID_2372NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2372NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2373NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2373NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2374NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanmature villous epithelial cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905NANA293306752017Pubchem_assay
PRRID_2374NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanmature villous epithelial cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905NANA293306752017Pubchem_assay
PRRID_2375NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancrypt epithelial cells,Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2375NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancrypt epithelial cells,Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2376NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humancrypt epithelial cells,Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2376NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humancrypt epithelial cells,Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2377NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA293306752017Pubchem_assay
PRRID_2377NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA293306752017Pubchem_assay
PRRID_2378NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA293306752017Pubchem_assay
PRRID_2378NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA293306752017Pubchem_assay
PRRID_2379NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2379NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2380NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humansecretory glands of the endocervixLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2380NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humansecretory glands of the endocervixLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2381NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanintracellular in human cer- vical epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904functionally responsive to their respective agonistsNA293306752017Pubchem_assay
PRRID_2381NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanintracellular in human cer- vical epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904functionally responsive to their respective agonistsNA293306752017Pubchem_assay
PRRID_2382NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanintracellular in human cer- vical epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032functionally responsive to their respective agonistsNA293306752017Pubchem_assay
PRRID_2382NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanintracellular in human cer- vical epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032functionally responsive to their respective agonistsNA293306752017Pubchem_assay
PRRID_2383NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Female pigapical surface of uterine epithelial cellsLeucine-rich Repeat (LRR) DomainNANANANAimmunohistofluorescent analysis293306752017NA
PRRID_2383NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Female pigapical surface of uterine epithelial cellsLeucine-rich Repeat (LRR) DomainNANANANAimmunohistofluorescent analysis293306752017NA
PRRID_2384NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Female pigapical surface of uterine epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NAimmunohistofluorescent analysis293306752017Pubchem_assay
PRRID_2384NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Female pigapical surface of uterine epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NAimmunohistofluorescent analysis293306752017Pubchem_assay