Detailed description page of PRRDB2.0
| This page displays user query in tabular form. |
PRRID_2324 details |
| Primary information | |
|---|---|
| PRRID | PRRID_2324 |
| Ligand Name | Mannan |
| Source | Fungi(Yeast) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Polysaccharides |
| Occurence | Natural |
| Role of Ligand | Activate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophages |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | NA |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | NA |
| Assay used | NA |
| PMID | 29028369 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |
| Primary information | |
|---|---|
| PRRID | PRRID_2324 |
| Ligand Name | Mannan |
| Source | Fungi(Yeast) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Polysaccharides |
| Occurence | Natural |
| Role of Ligand | Activate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophages |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | NA |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | NA |
| Assay used | NA |
| PMID | 29028369 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |