Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1816NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1816NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1817NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1817NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1818NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1818NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1819NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1819NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1820NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 21 (TLR21)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1820NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 21 (TLR21)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1821NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1821NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1827NA

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Streptococus agalactiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteriaqRT-PCR274172332016NA
PRRID_1827NA

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Streptococus agalactiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteriaqRT-PCR274172332016NA
PRRID_1828NA

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Vibrio harveyi (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KBqRT-PCR274172332016NA
PRRID_1828NA

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Vibrio harveyi (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KBqRT-PCR274172332016NA
PRRID_1829NA

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V. parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1829NA

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V. parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1831NA

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viral hemorrhagic septicemia (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantEcToll-like receptor 2b (TLR2b)Toll-like receptor (TLR)ZebrafishGills and spleenleucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.NANANAActivate NF-KbNA270372192016NA
PRRID_1831NA

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viral hemorrhagic septicemia (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantEcToll-like receptor 2b (TLR2b)Toll-like receptor (TLR)ZebrafishGills and spleenleucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.NANANAActivate NF-KbNA270372192016NA
PRRID_1832NA

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C. irritans (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantEcToll-like receptor 14 (TLR14)Toll-like receptor (TLR)ZebrafishGills and spleenleucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.NANANAActivate NF-KbNA270372192016NA
PRRID_1832NA

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C. irritans (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantEcToll-like receptor 14 (TLR14)Toll-like receptor (TLR)ZebrafishGills and spleenleucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.NANANAActivate NF-KbNA270372192016NA
PRRID_1833NA

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Vibrio anguillarum (Bacteria)NANANANaturalImmunostimulantMmiToll-like receptor 13 (TLR13) Toll-like receptor (TLR)miiuy croakerliver, spleen, and kidney,TIR domainNANANAactives the ISRE Luciferase assay269527672016NA
PRRID_1833NA

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Vibrio anguillarum (Bacteria)NANANANaturalImmunostimulantMmiToll-like receptor 13 (TLR13) Toll-like receptor (TLR)miiuy croakerliver, spleen, and kidney,TIR domainNANANAactives the ISRE Luciferase assay269527672016NA
PRRID_1834Nucleic acid

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H9N2(Avian influezna virus) (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses Avian influenza and act as immunostimulant for TLR.goToll-like receptor 7 (TLR7)Toll-like receptor (TLR)WaterfowllungsTIR domainNANANAProliferation of cytokines and activation of NF-kBqRT-PCR278329632016NA
PRRID_1834Nucleic acid

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H9N2(Avian influezna virus) (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses Avian influenza and act as immunostimulant for TLR.goToll-like receptor 7 (TLR7)Toll-like receptor (TLR)WaterfowllungsTIR domainNANANAProliferation of cytokines and activation of NF-kBqRT-PCR278329632016NA
PRRID_1835Nucleic acid

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Newcastle Disease Virus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses Newcastle disease and act as immunostimulant for TLR.goToll-like receptor 21 (TLR21)Toll-like receptor (TLR)WaterfowlEndoplasmic recticulumTIR domainNANANAProliferation of cytokines and activation of NF-kBqRT-PCR278329632016NA
PRRID_1835Nucleic acid

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Newcastle Disease Virus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses Newcastle disease and act as immunostimulant for TLR.goToll-like receptor 21 (TLR21)Toll-like receptor (TLR)WaterfowlEndoplasmic recticulumTIR domainNANANAProliferation of cytokines and activation of NF-kBqRT-PCR278329632016NA
PRRID_1837Pam3CSk4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QWS9.fastaF1QWS9818induce IFN expressionNA277214562016Pubchem_assay
PRRID_1837Pam3CSk4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QWS9.fastaF1QWS9818induce IFN expressionNA277214562016Pubchem_assay
PRRID_1845phenol-soluble modulin

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S. aureus (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInhibit proinflammatory cytokines TNF, IL-12 and IL-6NA267757992016NA
PRRID_1845phenol-soluble modulin

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S. aureus (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInhibit proinflammatory cytokines TNF, IL-12 and IL-6NA267757992016NA
PRRID_1847polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainB8JIL3.fastaB8JIL3903induce IFN expressionNA277214562016Pubchem_assay
PRRID_1847polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainB8JIL3.fastaB8JIL3903induce IFN expressionNA277214562016Pubchem_assay
PRRID_1848polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainB3DJL6.fastaB3DJL6947induce IFN expressionNA277214562016Pubchem_assay
PRRID_1848polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainB3DJL6.fastaB3DJL6947induce IFN expressionNA277214562016Pubchem_assay
PRRID_1849polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1849polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1850polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNANAO15455.fastaO15455904TLR3 (Poly I:C)-mediated, NO-dependent antiviral response [89] in murine embryonic fibroblastsNA272337992016Pubchem_assay
PRRID_1850polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNANAO15455.fastaO15455904TLR3 (Poly I:C)-mediated, NO-dependent antiviral response [89] in murine embryonic fibroblastsNA272337992016Pubchem_assay
PRRID_1851polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantMmiToll-like receptor 13 (TLR13) Toll-like receptor (TLR)miiuy croakerliver, spleen, and kidney,TIR domainNANANAactives the ISRE Luciferase assay269527672016NA
PRRID_1851polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticImmunostimulantMmiToll-like receptor 13 (TLR13) Toll-like receptor (TLR)miiuy croakerliver, spleen, and kidney,TIR domainNANANAactives the ISRE Luciferase assay269527672016NA
PRRID_1854Proteases

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Fasciola hepatica (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1854Proteases

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Fasciola hepatica (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Mice (Murine)NANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1855PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1855PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1856PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1856PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1857PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1857PS lipids

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üìp38NA271202222016Pubchem_assay
PRRID_1858PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1858PS lipids

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Ascaris lumbricoides/small intestine (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üì p38NA271202222016Pubchem_assay
PRRID_1859pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4ÔòºNA271202222016Pubchem_assay
PRRID_1859pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4ÔòºNA271202222016Pubchem_assay
PRRID_1860pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependentNA271202222016Pubchem_assay
PRRID_1860pseudocoelomic fluid (PCF)

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Ascaris suum/Intestine (pigs and human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependentNA271202222016Pubchem_assay
PRRID_1861PSM

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Staphylococcus epidermidis (Bacteria)NANANANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduce cytokine releaseNA267757992016NA
PRRID_1861PSM

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Staphylococcus epidermidis (Bacteria)NANANANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduce cytokine releaseNA267757992016NA
PRRID_1862rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üë Treg via TLR2 dependentNA271202222016Pubchem_assay
PRRID_1862rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784‚Üë Treg via TLR2 dependentNA271202222016Pubchem_assay
PRRID_1863rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üë Treg viaNA271202222016Pubchem_assay
PRRID_1863rAs-MIF

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Anisakis simplex/intestine (marine mammals, human)(others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784‚Üë Treg viaNA271202222016Pubchem_assay
PRRID_1864Resistin

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1864Resistin

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1865SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent ERK signaling and retinoic acidNA271202222016Pubchem_assay
PRRID_1865SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent ERK signaling and retinoic acidNA271202222016Pubchem_assay
PRRID_1866SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4NA271202222016Pubchem_assay
PRRID_1866SEA

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784Through either TLR2 or TLR4NA271202222016Pubchem_assay
PRRID_1867SHP-1

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Leishmania mexicana (others)NANANANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANALeads to TNF- alpha, IL-12, IL-10, and nitric oxide release in phagocytesNA267757992016NA
PRRID_1867SHP-1

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Leishmania mexicana (others)NANANANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANALeads to TNF- alpha, IL-12, IL-10, and nitric oxide release in phagocytesNA267757992016NA
PRRID_1869SJMHEÔõú

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathway TLRÔò∫-dependentNA271202222016Pubchem_assay
PRRID_1869SJMHEÔõú

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathway TLRÔò∫-dependentNA271202222016Pubchem_assay
PRRID_1870SJMHEÔõú

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Schistosoma japonicum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathwayNA271202222016Pubchem_assay
PRRID_1870SJMHEÔõú

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Schistosoma japonicum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependent induction of cRAF signaling pathwayNA271202222016Pubchem_assay
PRRID_1871SM-16

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicebloodNAQ9QUK6.fastaQ9QUK6835Inhibits degradation of the IRAK1 signalingNA271202222016Pubchem_assay
PRRID_1871SM-16

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S. mansoni (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicebloodNAQ9QUK6.fastaQ9QUK6835Inhibits degradation of the IRAK1 signalingNA271202222016Pubchem_assay
PRRID_1872SMÔõú-16Ôòæ

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Inhibits degradation of the IRAK1 signalingNA271202222016Pubchem_assay
PRRID_1872SMÔõú-16Ôòæ

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Inhibits degradation of the IRAK1 signalingNA271202222016Pubchem_assay
PRRID_1873TcES

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Taenia crassiceps (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2Ôò∫-dependent induction of cRAF signaling pathway TLR2Ôò∫-dependentNA271202222016Pubchem_assay
PRRID_1873TcES

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Taenia crassiceps (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUN7.fastaQ9QUN7784TLR2Ôò∫-dependent induction of cRAF signaling pathway TLR2Ôò∫-dependentNA271202222016Pubchem_assay
PRRID_1874TcES

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Taenia crassiceps (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependent ERK signaling and retinoic acidNA271202222016Pubchem_assay
PRRID_1874TcES

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Taenia crassiceps (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNANAQ9QUN7.fastaQ9QUN7784TLR2-dependent ERK signaling and retinoic acidNA271202222016Pubchem_assay
PRRID_1876Tenascin C

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NAMGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS2201Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1876Tenascin C

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NAMGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS2201Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1877TLR1–TLR2 heterodimer

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Zebrafishplasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainA0A0R4IW15.fastaA0A0R4IW15795induce IFN expressionNA277214562016Pubchem_assay
PRRID_1877TLR1–TLR2 heterodimer

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Zebrafishplasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainA0A0R4IW15.fastaA0A0R4IW15795induce IFN expressionNA277214562016Pubchem_assay
PRRID_1878Triacetylated lipoproteins

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Mycobacteria (Bacteria)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9EPQ1.fastaQ9EPQ1795increase TNF-a and IL-6NA277566042016Pubchem_assay
PRRID_1878Triacetylated lipoproteins

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Mycobacteria (Bacteria)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9EPQ1.fastaQ9EPQ1795increase TNF-a and IL-6NA277566042016Pubchem_assay
PRRID_1879Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)ColitisNANANANANA↑ TGF-β via TLR4-dependent mannerNA271202222016NA
PRRID_1879Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)ColitisNANANANANA↑ TGF-β via TLR4-dependent mannerNA271202222016NA
PRRID_1880Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Suppression of DC response to TRLsNA271202222016Pubchem_assay
PRRID_1880Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Suppression of DC response to TRLsNA271202222016Pubchem_assay
PRRID_1881Unknown

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H. polygyrus (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micesmall intestineNAQ9QUK6.fastaQ9QUK6835↑ TGF-β via TLR 4-dependent mannerNA271202222016Pubchem_assay
PRRID_1881Unknown

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H. polygyrus (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micesmall intestineNAQ9QUK6.fastaQ9QUK6835↑ TGF-β via TLR 4-dependent mannerNA271202222016Pubchem_assay
PRRID_1882Unmethylated CpG DNA

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Bacterial, viral genomeNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceDendritic cellextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9NR96.fastaQ9NR961032dendritic cells activation for innate and adaptive immunityNA277566042016Pubchem_assay
PRRID_1882Unmethylated CpG DNA

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Bacterial, viral genomeNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceDendritic cellextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9NR96.fastaQ9NR961032dendritic cells activation for innate and adaptive immunityNA277566042016Pubchem_assay
PRRID_189323S rRNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ6R5N8.fastaQ6R5N8991NALuciferase assay293077702017Pubchem_assay
PRRID_189323S rRNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ6R5N8.fastaQ6R5N8991NALuciferase assay293077702017Pubchem_assay
PRRID_18979-substituted 8-oxoade- nines

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NACC(C)(C)NC1=NC(=NC2=C1C=C(C=C2)C(F)(F)F)C(F)(F)FNAimidazoquinolinesSyntheticNAToll-like receptor 7/8 (TLR7/8)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA290498862017NA
PRRID_18979-substituted 8-oxoade- nines

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NACC(C)(C)NC1=NC(=NC2=C1C=C(C=C2)C(F)(F)F)C(F)(F)FNAimidazoquinolinesSyntheticNAToll-like receptor 7/8 (TLR7/8)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA290498862017NA