Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1361	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1361	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1362	hyaluronic acid oligosaccharides Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1362	hyaluronic acid oligosaccharides Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1363	hyaluronic acid oligosaccharides Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1363	hyaluronic acid oligosaccharides Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1518	oxidized lipids Click for more detail	Gram-negative bacteria	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1518	oxidized lipids Click for more detail	Gram-negative bacteria	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1561	peroxiredoxins Click for more detail	NA	MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK	199	Damage-associated molecular patterns (DAMPs)	Natural	released in brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1561	peroxiredoxins Click for more detail	NA	MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK	199	Damage-associated molecular patterns (DAMPs)	Natural	released in brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1562	peroxiredoxins Click for more detail	NA	MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK	199	Damage-associated molecular patterns (DAMPs)	Natural	released in brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O00206.fasta	O00206	839	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1562	peroxiredoxins Click for more detail	NA	MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK	199	Damage-associated molecular patterns (DAMPs)	Natural	released in brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O00206.fasta	O00206	839	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1609	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1609	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1671	Uric acid Click for more detail	Host (Endogenous) (others)	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1671	Uric acid Click for more detail	Host (Endogenous) (others)	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1672	Uric acid Click for more detail	Host (Endogenous) (others)	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1672	Uric acid Click for more detail	Host (Endogenous) (others)	C12=C(NC(=O)N1)NC(=O)NC2=O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1715	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1715	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1899	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	NA	NA	Q96P20.fasta	Q96P20	1036	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1899	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	NA	NA	Q96P20.fasta	Q96P20	1036	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1900	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	NA	NA	Q9C000.fasta	Q9C000	1473	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1900	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	NA	NA	Q9C000.fasta	Q9C000	1473	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1901	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	cluster of differentiation 36 (CD36)	Pattern recognition receptor (PRR)	Human	NA	NA	P16671.fasta	P16671	472	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1901	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	cluster of differentiation 36 (CD36)	Pattern recognition receptor (PRR)	Human	NA	NA	P16671.fasta	P16671	472	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1902	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	cluster of differentiation 14 (CD14)	Pattern recognition receptor (PRR)	Human	NA	NA	P08571.fasta	P08571	375	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1902	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	cluster of differentiation 14 (CD14)	Pattern recognition receptor (PRR)	Human	NA	NA	P08571.fasta	P08571	375	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1903	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1903	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1904	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	NA	NA	Q15109.fasta	Q15109	404	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1904	Ab Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	NA	NA	Q15109.fasta	Q15109	404	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1905	Actin Click for more detail	Cytosol(others)	MDGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF	376	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Dendritic cell NK lectin group receptor	NA	NA	NA	NA	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1905	Actin Click for more detail	Cytosol(others)	MDGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF	376	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Dendritic cell NK lectin group receptor	NA	NA	NA	NA	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1909	Aggrecan Click for more detail	Proteoglycan (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1909	Aggrecan Click for more detail	Proteoglycan (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1911	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28805121	2017	Pubchem_assay
PRRID_1911	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28805121	2017	Pubchem_assay
PRRID_1912	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1912	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1913	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1913	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1914	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Rat	primary astrocytes	NA	D4A523.fasta	D4A523	1035	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1914	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Rat	primary astrocytes	NA	D4A523.fasta	D4A523	1035	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1915	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1915	Amyloid-Œ≤ fibrils Click for more detail	NA	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Damage-associated molecular patterns (DAMPs)	Natural	Immunostimulant	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1925	ATP Click for more detail	Mitochondria (others)	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	P2X7	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1925	ATP Click for more detail	Mitochondria (others)	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	P2X7	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1926	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28805121	2017	Pubchem_assay
PRRID_1926	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Microglia	NA	Q8R4B8.fasta	Q8R4B8	1033	NLRP3 inflammasome activation in AD models	NA	28805121	2017	Pubchem_assay
PRRID_1927	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1927	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1928	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1928	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1929	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Rat	primary astrocytes	NA	D4A523.fasta	D4A523	1035	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1929	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Rat	primary astrocytes	NA	D4A523.fasta	D4A523	1035	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1930	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1930	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_1931	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Activate human dendritic cells	P2X7R	NOD-like receptor (NLR)	Human	Dendritic cells	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1931	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Activate human dendritic cells	P2X7R	NOD-like receptor (NLR)	Human	Dendritic cells	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1932	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Activate human dendritic cells	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Dendritic cells	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1932	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Activate human dendritic cells	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Dendritic cells	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1933	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ and IL-18 by human monocytes	P2X7R	NOD-like receptor (NLR)	Human	Monocyte	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1933	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ and IL-18 by human monocytes	P2X7R	NOD-like receptor (NLR)	Human	Monocyte	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1934	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ and IL-18 by human monocytes	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Monocyte	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1934	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ and IL-18 by human monocytes	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Monocyte	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1935	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ by murine and human neutrophils	P2X7R	NOD-like receptor (NLR)	Human	Neutrophils	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1935	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ by murine and human neutrophils	P2X7R	NOD-like receptor (NLR)	Human	Neutrophils	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1936	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ by murine and human neutrophils	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Neutrophils	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1936	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Induce the secretion of IL-1Œ≤ by murine and human neutrophils	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Neutrophils	NA	Q96P20.fasta	Q96P20	1036	NA	NA	28961019	2017	Pubchem_assay
PRRID_1980	Chromogranin A Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	activate microglial cells	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Activate NF-KB	NA	28049142	2017	NA
PRRID_1980	Chromogranin A Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	activate microglial cells	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Activate NF-KB	NA	28049142	2017	NA
PRRID_1981	Chromogranin A Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	activate microglial cells	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	NA	NA	Q96P20.fasta	Q96P20	1036	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1981	Chromogranin A Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	activate microglial cells	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	NA	NA	Q96P20.fasta	Q96P20	1036	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1982	Chromogranin A Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	activate microglial cells	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	NA	NA	Q15109.fasta	Q15109	404	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1982	Chromogranin A Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	activate microglial cells	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	NA	NA	Q15109.fasta	Q15109	404	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_1995	Decorin Click for more detail	Proteoglycan (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1995	Decorin Click for more detail	Proteoglycan (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1996	Decorin Click for more detail	Proteoglycan (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_1996	Decorin Click for more detail	Proteoglycan (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2016	endogenous glycoproteins Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Mannose Receptor 1	Mannose receptor (MR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2016	endogenous glycoproteins Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Mannose Receptor 1	Mannose receptor (MR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2017	endogenous glycoproteins Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Dectin-1	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2017	endogenous glycoproteins Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Dectin-1	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2026	Fibrinogen Click for more detail	ECM glycoprotein(others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2026	Fibrinogen Click for more detail	ECM glycoprotein(others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2027	Fibrinogen Click for more detail	Host (Endogenous) (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Mouse podocytes	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	29028369	2017	Pubchem_assay
PRRID_2027	Fibrinogen Click for more detail	Host (Endogenous) (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Mouse podocytes	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	29028369	2017	Pubchem_assay
PRRID_2097	Heat shock protein Click for more detail	Cytosol(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2097	Heat shock protein Click for more detail	Cytosol(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2098	Heat shock protein Click for more detail	Cytosol(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2098	Heat shock protein Click for more detail	Cytosol(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2099	Heat shock protein Click for more detail	Cytosol(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	cluster of differentiation 91 (CD91)	Pattern recognition receptor (PRR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2099	Heat shock protein Click for more detail	Cytosol(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	cluster of differentiation 91 (CD91)	Pattern recognition receptor (PRR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2102	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	plays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2102	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	plays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2103	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	plays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosis	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2103	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	plays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosis	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2104	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	plays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosis	cluster of differentiation 91 (CD91)	Pattern recognition receptor (PRR)	Human	NA	NA	Q71UW0.fasta	Q71UW0	92	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2104	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	plays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosis	cluster of differentiation 91 (CD91)	Pattern recognition receptor (PRR)	Human	NA	NA	Q71UW0.fasta	Q71UW0	92	Activate NF-KB	NA	28049142	2017	Pubchem_assay

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