Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_2550	periplasmic flagella Click for more detail	T. denticola (Bacteria)	MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ	349	Pattern-associated molecular patterns (PAMPs)	Natural	periodontal inflammation;	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29084899	2017	Pubchem_assay
PRRID_2550	periplasmic flagella Click for more detail	T. denticola (Bacteria)	MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ	349	Pattern-associated molecular patterns (PAMPs)	Natural	periodontal inflammation;	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29084899	2017	Pubchem_assay
PRRID_2552	phosphatidyl-myo-inositol mannosides (PIM) Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	THP‚Äê1 macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	Pubchem_assay
PRRID_2552	phosphatidyl-myo-inositol mannosides (PIM) Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	THP‚Äê1 macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	Pubchem_assay
PRRID_2553	phosphatidyl-myo-inositol mannosides (PIM) Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	CR3	Complement Receptor	Human	THP‚Äê1 macrophages	NA	NA	NA	NA	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	NA
PRRID_2553	phosphatidyl-myo-inositol mannosides (PIM) Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	CR3	Complement Receptor	Human	THP‚Äê1 macrophages	NA	NA	NA	NA	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	NA
PRRID_2554	Phospholipomannan Click for more detail	NA	NA	NA	NA	Natural	induce cardiomyocyte inflammation, activate NF-Œ∫B, and up-regulate the expression of pro-inflammatory cytokines in human monocytes in a CDÔõúÔòº-dependent fashion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human keratinocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2554	Phospholipomannan Click for more detail	NA	NA	NA	NA	Natural	induce cardiomyocyte inflammation, activate NF-Œ∫B, and up-regulate the expression of pro-inflammatory cytokines in human monocytes in a CDÔõúÔòº-dependent fashion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human keratinocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2557	poli I/C, resveratrol Click for more detail	NA	NA	NA	NA	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	ELISA	29039348	2017	Pubchem_assay
PRRID_2557	poli I/C, resveratrol Click for more detail	NA	NA	NA	NA	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	ELISA	29039348	2017	Pubchem_assay
PRRID_2558	polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT]) Click for more detail	Bacteria	CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2558	polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT]) Click for more detail	Bacteria	CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2559	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29353310	2017	Pubchem_assay
PRRID_2559	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29353310	2017	Pubchem_assay
PRRID_2562	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	anti- inflammatory activity	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29113797	2017	Pubchem_assay
PRRID_2562	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	anti- inflammatory activity	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29113797	2017	Pubchem_assay
PRRID_2565	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2565	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2571	Polyman26 Click for more detail	NA	NA	NA	Agonist	Synthetic	Activation of CLRs.	Dectin-2	C type Lectin (CTL/CLR)	Human	Plasma membrane	carbohydrate recognition domain (CRD)	Q6EIG7.fasta	Q6EIG7	209	inhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.	Flow cytometry	28776416	2017	Pubchem_assay
PRRID_2571	Polyman26 Click for more detail	NA	NA	NA	Agonist	Synthetic	Activation of CLRs.	Dectin-2	C type Lectin (CTL/CLR)	Human	Plasma membrane	carbohydrate recognition domain (CRD)	Q6EIG7.fasta	Q6EIG7	209	inhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.	Flow cytometry	28776416	2017	Pubchem_assay
PRRID_2573	Porin PorB Click for more detail	NA	NA	NA	NA	Natural	Induce TLRÔõú signaling after binding to TLRÔò∫	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29028369	2017	Pubchem_assay
PRRID_2573	Porin PorB Click for more detail	NA	NA	NA	NA	Natural	Induce TLRÔõú signaling after binding to TLRÔò∫	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29028369	2017	Pubchem_assay
PRRID_2574	Porins Click for more detail	NA	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	NA	Natural	Cell activation, induce NFŒ∫B activation, Induction of the IL-ÔôÄ promoter	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2574	Porins Click for more detail	NA	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	NA	Natural	Cell activation, induce NFŒ∫B activation, Induction of the IL-ÔôÄ promoter	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2578	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	NA	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29263932	2017	NA
PRRID_2578	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	NA	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	29263932	2017	NA
PRRID_2579	Quil-A Click for more detail	Quillaja sponaria tree (plant)	NA	NA	steroidal or triterpenoid aglycones	Natural	Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-Œ∫B-mediated expression of inflammatory cytokines	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Intracellular	C-terminal leucine-rich regions and NOD domains	Q96P20.fasta	Q96P20	1036	triggering production of Œ≤-defensins via an NF-Œ∫B signaling pathway	NA	28776416	2017	Pubchem_assay
PRRID_2579	Quil-A Click for more detail	Quillaja sponaria tree (plant)	NA	NA	steroidal or triterpenoid aglycones	Natural	Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-Œ∫B-mediated expression of inflammatory cytokines	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Intracellular	C-terminal leucine-rich regions and NOD domains	Q96P20.fasta	Q96P20	1036	triggering production of Œ≤-defensins via an NF-Œ∫B signaling pathway	NA	28776416	2017	Pubchem_assay
PRRID_2580	R837 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes. Innate immune cells except neutrophils and pDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2580	R837 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes. Innate immune cells except neutrophils and pDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2581	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2581	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2582	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2582	R848 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2590	RNA Click for more detail	Streptococcus (Bacteria)	NA	NA	NA	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	23S rRNA motif,	Q9NR97.fasta	Q9NR97	1041	NA	NA	29042860	2017	Pubchem_assay
PRRID_2590	RNA Click for more detail	Streptococcus (Bacteria)	NA	NA	NA	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	23S rRNA motif,	Q9NR97.fasta	Q9NR97	1041	NA	NA	29042860	2017	Pubchem_assay
PRRID_2592	RNA Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2592	RNA Click for more detail	All vertebrates(others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	Cellular injury and necrosis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2597	ROS Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2597	ROS Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Brain	NA	Q96P20.fasta	Q96P20	1036	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_2603	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2603	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2604	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2604	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2605	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	NA	NA	Q15109.fasta	Q15109	404	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2605	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	acts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	NA	NA	Q15109.fasta	Q15109	404	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2606	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Promote human neutrophil migration	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2606	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Promote human neutrophil migration	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2607	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Promote human neutrophil migration	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2607	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Promote human neutrophil migration	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2608	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the production of TNF-Œ±, IL-1Œ≤, and IL-12 by human monocytes	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Monocyte	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2608	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the production of TNF-Œ±, IL-1Œ≤, and IL-12 by human monocytes	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Monocyte	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2609	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the production of TNF-Œ±, IL-1Œ≤, and IL-12 by human monocytes	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Monocyte	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2609	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the production of TNF-Œ±, IL-1Œ≤, and IL-12 by human monocytes	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Monocyte	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2610	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the expression levels of the adhesion	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils and HUVECs	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2610	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the expression levels of the adhesion	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils and HUVECs	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2611	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the expression levels of the adhesion	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils and HUVECs	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2611	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	Induce the expression levels of the adhesion	RAGE	Receptor for advanced glycation endproducts (RAGE)	Human	Neutrophils and HUVECs	NA	Q15109.fasta	Q15109	404	NA	NA	28961019	2017	Pubchem_assay
PRRID_2612	SAP130 Click for more detail	dead or dying cells(others)	NA	NA	NA	Natural	NA	CLEC4E	C type Lectin (CTL/CLR)	Human	NA	C-Type Lectin domain family 4, member E	Q9ULY5.fasta	Q9ULY5	219	NA	NA	29066255	2017	Pubchem_assay
PRRID_2612	SAP130 Click for more detail	dead or dying cells(others)	NA	NA	NA	Natural	NA	CLEC4E	C type Lectin (CTL/CLR)	Human	NA	C-Type Lectin domain family 4, member E	Q9ULY5.fasta	Q9ULY5	219	NA	NA	29066255	2017	Pubchem_assay
PRRID_2614	short dsRNA Click for more detail	EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	K63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerization	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm, all mammalian cell types	NA	O95786.fasta	O95786	925	MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2614	short dsRNA Click for more detail	EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	K63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerization	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm, all mammalian cell types	NA	O95786.fasta	O95786	925	MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29066255	2017	Pubchem_assay
PRRID_2617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29066255	2017	Pubchem_assay
PRRID_2618	single-stranded RNA Click for more detail	exogenous viruses (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	cellular endosomal compartments,	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2618	single-stranded RNA Click for more detail	exogenous viruses (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	cellular endosomal compartments,	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Induce production of inflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	airway and lung epithelial Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29028369	2017	Pubchem_assay
PRRID_2621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Induce production of inflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	airway and lung epithelial Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29028369	2017	Pubchem_assay
PRRID_2622	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29028369	2017	Pubchem_assay
PRRID_2622	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29028369	2017	Pubchem_assay
PRRID_2627	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2627	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2628	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2628	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2634	ssRNA40/LyoVec Click for more detail	NA	NA	NA	NA	Synthetic	anti- inflammatory activity	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29113797	2017	Pubchem_assay
PRRID_2634	ssRNA40/LyoVec Click for more detail	NA	NA	NA	NA	Synthetic	anti- inflammatory activity	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29113797	2017	Pubchem_assay
PRRID_2637	sulfoglycolipids Click for more detail	Mycobacterium tuberculosis (Bacteria)	CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCC	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Tuberculosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	inhibit NF-Œ∫B activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonists	TLR2 Binding assay	28973928	2017	Pubchem_assay
PRRID_2637	sulfoglycolipids Click for more detail	Mycobacterium tuberculosis (Bacteria)	CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCC	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Tuberculosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	inhibit NF-Œ∫B activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonists	TLR2 Binding assay	28973928	2017	Pubchem_assay
PRRID_2638	synthetic dsRNA Click for more detail	MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	dsRNA induced dimerization	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes. Innate immune cells except neutrophils and pDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2638	synthetic dsRNA Click for more detail	MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	dsRNA induced dimerization	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Endosomes. Innate immune cells except neutrophils and pDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2646	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mcl (Clec4d)	Syk-coupled CLR	Human	NA	NA	Q8WXI8.fasta	Q8WXI8	215	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2646	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mcl (Clec4d)	Syk-coupled CLR	Human	NA	NA	Q8WXI8.fasta	Q8WXI8	215	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2648	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Human	NA	NA	Q9ULY5.fasta	Q9ULY5	219	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2648	TDM Click for more detail	Mycobacterium spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Human	NA	NA	Q9ULY5.fasta	Q9ULY5	219	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2652	TLR 2 ligand Click for more detail	NA	NA	NA	NA	Natural	Enhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAE	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cell surface and in the cytoplasm of bronchiolar epithelial cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29330675	2017	Pubchem_assay
PRRID_2652	TLR 2 ligand Click for more detail	NA	NA	NA	NA	Natural	Enhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAE	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cell surface and in the cytoplasm of bronchiolar epithelial cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29330675	2017	Pubchem_assay
PRRID_2653	TLR 2 ligand Click for more detail	NA	NA	NA	NA	Natural	Enhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAE	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	apical membrane of murine small IECs	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29330675	2017	Pubchem_assay
PRRID_2653	TLR 2 ligand Click for more detail	NA	NA	NA	NA	Natural	Enhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAE	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	apical membrane of murine small IECs	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29330675	2017	Pubchem_assay
PRRID_2654	TLR4 ligand Click for more detail	NA	NA	NA	NA	Natural	Enhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAE	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Cell surface and in the cytoplasm of bronchiolar epithelial cells	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	NA	NA	29330675	2017	Pubchem_assay
PRRID_2654	TLR4 ligand Click for more detail	NA	NA	NA	NA	Natural	Enhanced mu- rine FAE transport of microparticles and induced migration of subepithelial DCs into the FAE	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Cell surface and in the cytoplasm of bronchiolar epithelial cells	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	NA	NA	29330675	2017	Pubchem_assay
PRRID_2655	TMX-20x Click for more detail	NA	NA	NA	Phospholipid	Synthetic	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	hTLR7 Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	DLS, EPR and cytotoxicity assessment	29200306	2017	Pubchem_assay
PRRID_2655	TMX-20x Click for more detail	NA	NA	NA	Phospholipid	Synthetic	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	hTLR7 Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	DLS, EPR and cytotoxicity assessment	29200306	2017	Pubchem_assay
PRRID_2656	TMX-30x Click for more detail	NA	NA	NA	1V209-PEG	Synthetic	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	hTLR7 Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29200306	2017	Pubchem_assay
PRRID_2656	TMX-30x Click for more detail	NA	NA	NA	1V209-PEG	Synthetic	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	hTLR7 Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29200306	2017	Pubchem_assay
PRRID_2657	trehalose 6,6‚Ä≤-dimycolate Click for more detail	Mycobacteria (Bacteria)	CCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)C(=O)OCC2C(C(C(C(O2)OC3C(C(C(C(O3)COC(=O)C(CCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O)O	NA	Glycolipid	Natural	NA	CLEC4E	C type Lectin (CTL/CLR)	Human	NA	C-Type Lectin domain family 4, member E	Q9ULY5.fasta	Q9ULY5	219	NA	NA	29066255	2017	Pubchem_assay
PRRID_2657	trehalose 6,6‚Ä≤-dimycolate Click for more detail	Mycobacteria (Bacteria)	CCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)C(=O)OCC2C(C(C(C(O2)OC3C(C(C(C(O3)COC(=O)C(CCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O)O	NA	Glycolipid	Natural	NA	CLEC4E	C type Lectin (CTL/CLR)	Human	NA	C-Type Lectin domain family 4, member E	Q9ULY5.fasta	Q9ULY5	219	NA	NA	29066255	2017	Pubchem_assay
PRRID_2658	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29263932	2017	Pubchem_assay
PRRID_2658	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29263932	2017	Pubchem_assay
PRRID_2659	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29263932	2017	Pubchem_assay
PRRID_2659	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29263932	2017	Pubchem_assay

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