Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_5108Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5109Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5110Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5111Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5112Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5113Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5114Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5115Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5116Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5117Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result40% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5118Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5119Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5120Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result90% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5121Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result70% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5122Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5123Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineSK-MEL-2Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5124Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismC57BL/6 mice xenograft for B16-OVA (1.0E+5 cells)In-vivo virus concentration3.0E+6 on day 0 and 1.0E+6 on day 2In-vivo toxicityNA In-vivo resultReduction in tumor volume to 100 cubic mm compared to control 500 cubic mm after 12 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5125Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismC57BL/6 mice xenograft for B16-OVA (1.0E+5 cells)In-vivo virus concentration3.0E+6 on day 0 and 1.0E+6 on day 2In-vivo toxicityNA In-vivo resultComplete reduction in tumor volumecompared to control 500 cubic mm after 12 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5413Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine lymphosarcoma cell lineCell lineRLSConcentration of cell line80% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5414Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine lymphosarcoma cell lineCell lineRLSConcentration of cell line80% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5415Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine lymphosarcoma cell lineCell lineRLSConcentration of cell line80% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5416Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine lymphosarcoma cell lineCell lineRLS-40Concentration of cell line80% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5417Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine lymphosarcoma cell lineCell lineRLS-40Concentration of cell line80% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5418Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine lymphosarcoma cell lineCell lineRLS-40Concentration of cell line80% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5419Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine melanomaCell lineB16Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result57% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5420Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine melanomaCell lineB16Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result42% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5421Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineMurine melanomaCell lineB16Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result22% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5422Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineHuman cervical carcinomaCell lineKB-3-1Concentration of cell line9.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result64% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5423Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineHuman cervical carcinomaCell lineKB-3-1Concentration of cell line9.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5424Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineHuman cervical carcinomaCell lineKB-3-1Concentration of cell line9.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result17% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5425Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineHuman cervical carcinomaCell lineKB-8-5Concentration of cell line9.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5426Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineHuman cervical carcinomaCell lineKB-8-5Concentration of cell line9.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5427Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineRussian academy of scienceOrigin of cell lineHuman cervical carcinomaCell lineKB-8-5Concentration of cell line9.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result35% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5428Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismC57Bl6 mice subcutaneous injected for 1.0E+5 B16 cellsIn-vivo virus concentration5.0E+7 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume to below 0.3 cubic cm compared to control 1.2 cubic cm after 20 daysMode of deliveryIntratumoralPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5429Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismCBA mice sintramuscularly injected for 5.0E+7 RLS-40 cellsIn-vivo virus concentration5.0E+7 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume to below 0.2 cubic cm compared to control 0.8 cubic cm after 15 daysMode of deliveryIntratumoralPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520
IDOV_5457Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c mice injected with tumorIn-vivo virus concentration1.0E+4 pfuIn-vivo toxicityNA In-vivo resultMice failed to develop cancerMode of deliverySubcutaneousPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS41098983
IDOV_5458Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c mice injected with tumorIn-vivo virus concentration1.0E+5 pfuIn-vivo toxicityNA In-vivo resultMice failed to develop cancerMode of deliverySubcutaneousPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS41098983
IDOV_5459Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c mice injected with tumorIn-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultMice failed to develop cancerMode of deliverySubcutaneousPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS41098983
IDOV_5682Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 261.8mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5683Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 248.4mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5684Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 216.8mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5685Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 208.8mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5686Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 157.2mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5687Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 280.3mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5688Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 301.9mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5689Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 273.5mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5690Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 243.8mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5691Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 286mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5692Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 267.1mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5693Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 155.6mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5694Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 310.9mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5695Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 416.9mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5696Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 536.1mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5697Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 5550.4mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5698Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 463.4mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5699Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 543.3mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5700Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 320.1mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5701Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 679mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5702Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 660mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5703Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 701.4mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5704Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 761.3mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5705Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 706.6mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5706Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 721.3mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5707Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 476.3mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5708Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 864.1mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5709Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 828.6mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5710Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 978.4mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5711Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 852mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5712Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 985.5mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5713Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 936.1mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5714Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 695mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5715Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1179.9mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5716Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 897.4mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5717Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1485mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5718Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1053mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5719Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 852mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5720Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 606mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5721Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 751mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5722Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 166.7mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5723Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor volume after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5724Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1536.9mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5725Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 962.2mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5726Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 579.2mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5727Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 546.9mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5728Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 720.1mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5729Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 117.8mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5730Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor volume after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5731Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 412.9mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5732Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 350.2mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5733Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 341.1mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5734Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 353.4mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5735Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 392.25mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5736Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 305.6mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5737Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 350.65mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5738Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 419.55mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5739Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 750.4mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5740Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 722.3mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5741Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 819.8mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5742Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1081.2mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5743Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1222.25mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968