Detailed description page of Selected OV_ID


OV_5428 details
Primary information
OV_IDOV_5428
Virus Name Vaccinia virus
StrainLIVP-GFP
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeDeletion mutant for tk gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC57Bl6 mice subcutaneous injected for 1 × 10⁵ B16 cells
In-vivo virus concentration5 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to below 0.3 cubic cm compared to control 1.2 cubic cm after 20 days
Mode of deliveryIntratumoral
Pathway inductionReduction production of IL-6 indicating tumor inhibition
Immunogenic effectNA
Clinical trialNA
PMID27538520