| Primary information |
|---|
| OV_ID | OV_5125 |
| Virus Name | Vaccinia virus |
| Strain | vvdd-tdTomato-mDAI |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Deletion of tk gene and vaccinia growth gene and addition of murine DAI |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | Virus expressing murine DAI gene |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C57BL/6 mice xenograft for B16-OVA (1 × 10ⵠcells) |
| In-vivo virus concentration | 3 × 10ⶠon day 0 and 1 × 10ⶠon day 2 |
| In-vivo toxicity | NA |
| In-vivo result | Complete reduction in tumor volumecompared to control 500 cubic mm after 12 days |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | Induction of Immunogenic gene such as T cell activation |
| Clinical trial | NA |
| PMID | 27626058 |