| Primary information |
|---|
| OV_ID | OV_5429 |
| Virus Name | Vaccinia virus |
| Strain | LIVP-GFP |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Deletion mutant for tk gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | CBA mice sintramuscularly injected for 5 × 10ⷠRLS-40 cells |
| In-vivo virus concentration | 5 × 10ⷠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to below 0.2 cubic cm compared to control 0.8 cubic cm after 15 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Reduction production of IL-6 indicating tumor inhibition |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27538520 |