Detailed description page of Selected OV_ID


OV_5124 details
Primary information
OV_IDOV_5124
Virus Name Vaccinia virus
Strainvvdd-tdTomato-hDAI
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeDeletion of tk gene and vaccinia growth gene and addition of human DAI
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing human DAI gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC57BL/6 mice xenograft for B16-OVA (1 × 10⁵ cells)
In-vivo virus concentration3 × 10⁶ on day 0 and 1 × 10⁶ on day 2
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 100 cubic mm compared to control 500 cubic mm after 12 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectInduction of Immunogenic gene such as T cell activation
Clinical trialNA
PMID27626058