The total number of records retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_19	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	1 MOI	70% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_20	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	5 MOI	58% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_21	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	10 MOI	38% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_22	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	1 MOI	100% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_23	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	5 MOI	95% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_24	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	10 MOI	94% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_25	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	1 MOI	77% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_26	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	5 MOI	72% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_27	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	ATCC	Human lung cancer cell line	A549	Grown to 70% confluence	NA	MTT assay	10 MOI	58% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_40	Adenovirus	AdCMV/GFP	DNA	Adenoviridae	Mutant with E1 deletion carrying a green fluorescent protein (GFP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	Desnity of 1000000 in 60mm dish	Highly toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI	MTT assay	3.5 MOI	13% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26475304
OV_41	Adenovirus	Ad dl1520	DNA	Adenoviridae	E1b mutant with 827-bp deletion and a point mutation with premature stop codon in the E1B55K coding region	Yes	No	No	ATCC	Human lung cancer cell line	A549	Desnity of 1000000 in 60mm dish	Minimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI	MTT assay	3.5 MOI	54% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26475304
OV_42	Adenovirus	Ad-cycE	DNA	Adenoviridae	E1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	Desnity of 1000000 in 60mm dish	Minimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI	MTT assay	3.5 MOI	18% cancer cell viability	No	No	NA	No response	NA	NA	Activates CDK2 and targets the transcriptional repressor pRb	NA	26475304
OV_47	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	NA	MTT assay	0.1 MOI	57% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_48	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	No	Viral strain in combination with etoposide (0.5 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.67 CDI	MTT assay	0.1 MOI	24% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_49	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	No	Viral strain in combination with epirubicin (0.5 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.46 CDI	MTT assay	0.1 MOI	16% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_50	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	No	Viral strain in combination with doxorubicin (0.1 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.88 CDI	MTT assay	0.1 MOI	26% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_51	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	No	Viral strain in combination with vincristine (0.1 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.79 CDI	MTT assay	0.1 MOI	25% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_52	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	No	Viral strain in combination with colchcine (0.02 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.81 CDI	MTT assay	0.1 MOI	28% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_53	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	NA	MTT assay	0.1 MOI	18% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_54	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	No	Viral strain in combination with etoposide (0.5 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.27 CDI	MTT assay	0.1 MOI	4% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_55	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	No	Viral strain in combination with epirubicin (0.5 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.31 CDI	MTT assay	0.1 MOI	4% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_56	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	No	Viral strain in combination with doxorubicin (0.1 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.33 CDI	MTT assay	0.1 MOI	6% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_57	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	No	Viral strain in combination with vincristine (0.1 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.89 CDI	MTT assay	0.1 MOI	12% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_58	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	No	Viral strain in combination with colchcine (0.02 μg/ml)	No	NA	Human lung cancer cell line	A549	1.0E+6 cells per well	0.78 CDI	MTT assay	0.1 MOI	10% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_314	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	0.5 MOI	28% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_315	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	0.5 MOI	78% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_316	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	0.5 MOI	24% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_317	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 MOI	24% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_318	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 MOI	57% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_319	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 MOI	18% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_320	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	2 MOI	22% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_321	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	2 MOI	45% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_322	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	2 MOI	11% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_325	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	2.5E+4 cells per well	NA	Crystal violet staining	1 MOI	98% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_326	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	Crystal violet staining	1 MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_327	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	Crystal violet staining	1 MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_328	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	Crystal violet staining	1 MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_329	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	2.5E+4 cells per well	NA	Crystal violet staining	2.5 MOI	98% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_330	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	Crystal violet staining	2.5 MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_331	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	Crystal violet staining	2.5 MOI	2% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_332	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	Crystal violet staining	2.5 MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_333	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	2.5E+4 cells per well	NA	Crystal violet staining	5 MOI	98% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_334	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	Crystal violet staining	5 MOI	92% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_335	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	Crystal violet staining	5 MOI	3% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_336	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	Crystal violet staining	5 MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_337	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	2.5E+4 cells per well	NA	Crystal violet staining	10 MOI	99% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_338	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	Crystal violet staining	10 MOI	92% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_339	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	Crystal violet staining	10 MOI	20% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_340	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	Crystal violet staining	10 MOI	2% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_341	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H-1299	2.5E+4 cells per well	NA	Crystal violet staining	20 MOI	100% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_342	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	Crystal violet staining	20 MOI	100% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_343	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	Crystal violet staining	20 MOI	80% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_344	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	Crystal violet staining	20 MOI	45% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_345	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	58% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_346	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	MTT assay	10 MOI	62% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_347	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	MTT assay	10 MOI	74% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_348	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) - 0.6 mM	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	2.5 MOI	18% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy	NA	NA	26561948
OV_349	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) - 0.75 mM	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	MTT assay	20 MOI	22% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy	NA	NA	26561948
OV_350	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) - 1 mM	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	MTT assay	10 MOI	12% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy	NA	NA	26561948
OV_351	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	49% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_352	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	26% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_353	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	62% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)	NA	NA	26561948
OV_354	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	44% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)	NA	NA	26561948
OV_355	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and BAF-A1 at -0.75 mM and 10 nM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	65% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by Baf-A1)	NA	NA	26561948
OV_356	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and BAF-A1 at -0.75 mM and 10 nM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	47% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by Baf-A1)	NA	NA	26561948
OV_1100	Adenovirus	ZD55-IL-24	DNA	Adenoviridae	Adenovirus expressing ZD55 gene and IL-24 gene	Yes	No	Expressing IL-24 gene	Shanghai cell collection	Human lung fibroblast cell line	NHLF	2.0E+6 cells per well	NA	MTT assay	5 MOI	No cell killing after 80 hours	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1101	Adenovirus	Ad-IL-24	DNA	Adenoviridae	Adenovirus expressing IL-24 gene	Yes	No	Expressing IL-24 gene	Shanghai cell collection	Human lung fibroblast cell line	NHLF	2.0E+6 cells per well	NA	MTT assay	5 MOI	No cell killing after 80 hours	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1102	Adenovirus	ZD55-EGFP	DNA	Adenoviridae	Adenovirus expressing EGFP gene	Yes	No	No	Shanghai cell collection	Human lung fibroblast cell line	NHLF	2.0E+6 cells per well	NA	MTT assay	5 MOI	No cell killing after 80 hours	No	No	NA	No response	NA	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_2065	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung cancer cell line	MRC-5	NA	NA	Crystal violet staining	0.1 MOI	No cell death observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2066	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung cancer cell line	MRC-5	NA	NA	Crystal violet staining	1 MOI	No cell seath observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2067	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung cancer cell line	MRC-5	NA	NA	Crystal violet staining	10 MOI	No cell death observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2068	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung cancer cell line	MRC-5	NA	NA	Crystal violet staining	100 MOI	Cell death observed	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	21794078
OV_2069	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung bronchi cell line	BEAS-2B	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2070	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung bronchi cell line	BEAS-2B	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2071	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung bronchi cell line	BEAS-2B	NA	NA	Crystal violet staining	10 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2072	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung bronchi cell line	BEAS-2B	NA	NA	Crystal violet staining	100 MOI	All cells was dead	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	21794078
OV_2077	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2078	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	1 MOI	All cells was dead	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2079	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	10 MOI	All cells was dead	No	No	NA	No response	NA	Induction of senescence	NA	NA	21794078
OV_2080	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	100 MOI	All cells was dead	No	No	NA	No response	NA	Induction of apoptosis	NA	NA	21794078
OV_2106	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2107	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2108	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	10 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2109	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	100 MOI	Most of the cells are died	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2126	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2127	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2128	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	10 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2129	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human lung adenocarcinoma cell line	A549	NA	NA	Crystal violet staining	100 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2211	Newcastle disease virus	wild type	RNA	Paramyxoviridae	None	No	Virus in combination with cisplatin	No	Chinese academy of sciece	Human small cell lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549 cell line	1.0E+7 pfu	NA	Tumor volume decreased to 500mm after 57 days	Intratumoral	Induction of caspase and apoptotic pathway as detected by Hoechst staining and TUNEL assay	NA	NA	22095029
OV_2437	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2438	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2439	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	90% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2440	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	90% cell survival after day 7	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2441	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	80% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2477	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2478	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	60% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2479	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	50% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2480	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	45% cell survival after day 7	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2481	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	100% cell death after day 9	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2514	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human lung cancer cell line	H1650	3.0E+4 cells per well	NA	LDH release and spectrophometer	1 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22258815