The total number record retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_652	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	75% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_653	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_654	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	106% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_655	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	95% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_656	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	89% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_657	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	39% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_658	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_659	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_660	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	96% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_661	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_662	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_663	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_664	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	88% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_665	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	94% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_666	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_667	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	91% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_668	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	88% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_669	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	98% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_670	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	78% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_671	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_672	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	20% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_673	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	12% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_674	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_675	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_676	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	17% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_677	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	8% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_678	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	8% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_679	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to mock-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_680	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_681	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_682	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_683	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_684	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_685	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_686	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_687	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_688	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	1 MOI	30% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_689	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_690	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	126% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_691	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_692	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	72% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_693	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	1 MOI	61% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_694	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_695	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_696	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_697	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	99% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_698	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_699	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	108% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_700	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_701	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_702	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	85% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_703	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_704	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_705	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_706	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_707	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_708	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	19% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_727	Vaccinia virus	VV-Onco	DNA	Poxviridae	The viral thymidine kinase (TK) gene is insertionally inactivated	Yes	No	No	Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China	Human hepatocellular carcinoma cell line	MHCC97-H	5000 to 7000 cells per well	NA	MTT assay	1 MOI	70% cancer cell viability at 96 hours post-infection	No	No	NA	No response	NA	NA	NA	NA	27441866
OV_728	Vaccinia virus	VV-Onco	DNA	Poxviridae	The viral thymidine kinase (TK) gene is insertionally inactivated	Yes	No	No	Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China	Human hepatocellular carcinoma cell line	MHCC97-H	5000 to 7000 cells per well	NA	MTT assay	10 MOI	50% cancer cell viability at 96 hours post-infection	No	No	NA	No response	NA	NA	NA	NA	27441866
OV_729	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	10 MOI	97% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_730	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	10 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_731	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	52% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_732	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	50% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_733	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	33% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_734	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	38% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_735	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_736	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_737	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	50 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_738	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	50 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_739	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2	1.0E+4 cells per well	NA	MTT assay	100 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_740	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	100 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_741	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	80% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_742	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	50% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_743	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	65% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_744	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	45% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_745	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	61% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_746	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	61% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_747	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	46% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_748	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with negative control	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	46% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_856	Adenovirus	CV890	DNA	Adenoviridae	E1A and E1B gene under control of Adenovirus promoter	No	Virus strain in combination with Doxorubicin (10ng/ml)	No	ATCC	Human hepatoma cell line	Hep3B	NA	NA	MTT assay	0.01pfu/cell	90% cancer cell killing after day 9, showing synergism with drug	No	No	NA	No response	NA	NA	NA	NA	11522637
OV_857	Adenovirus	CV890	DNA	Adenoviridae	E1A and E1B gene under control of Adenovirus promoter	Yes	No	No	ATCC	Human hepatoma cell line	Hep3B	NA	NA	MTT assay	0.01pfu/cell	35% cancer cell killing after day 9	No	No	NA	No response	NA	NA	NA	NA	11522637
OV_860	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	1 MOI	94% cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_861	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Triple-negative breast cancer cell line	MDA-MB-231	NA	NA	MTT assay	1 MOI	75 % cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_862	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human colorectal adenocarcinoma cell line	HT-29	NA	NA	MTT assay	1 MOI	80 % cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_863	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	1 MOI	99% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_864	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Triple-negative breast cancer cell line	MDA-MB-231	NA	NA	MTT assay	1 MOI	92% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_865	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human colorectal adenocarcinoma cell line	HT-29	NA	NA	MTT assay	1 MOI	96% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_866	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	0.1 MOI	60% cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_867	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Triple-negative breast cancer cell line	MDA-MB-231	NA	NA	MTT assay	0.1 MOI	40 % cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_868	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human colorectal adenocarcinoma cell line	HT-29	NA	NA	MTT assay	0.1 MOI	60 % cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_869	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	0.1 MOI	95% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_870	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Triple-negative breast cancer cell line	MDA-MB-231	NA	NA	MTT assay	0.1 MOI	80% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_871	Herpes simplex virus	BL1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human colorectal adenocarcinoma cell line	HT-29	NA	NA	MTT assay	0.1 MOI	80% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_872	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	1 MOI	94% cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_873	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Triple-negative breast cancer cell line	MDA-MB-231	NA	NA	MTT assay	1 MOI	85 % cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_874	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human colorectal adenocarcinoma cell line	HT-29	NA	NA	MTT assay	1 MOI	85 % cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_875	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	1 MOI	98% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_876	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Triple-negative breast cancer cell line	MDA-MB-231	NA	NA	MTT assay	1 MOI	96% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_877	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human colorectal adenocarcinoma cell line	HT-29	NA	NA	MTT assay	1 MOI	97% cancerous cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12595888
OV_878	Herpes simplex virus	JS1	DNA	Herpesviridae	None	Yes	No	No	ATCC	Cellosaurus cell line	SK-MEL-28	NA	NA	MTT assay	0.1 MOI	60% cancerous cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12595888