Detailed description page of Selected OV_ID


OV_673 details
Primary information
OV_IDOV_673
Virus Name Reovirus
StrainRT3D (Reolysin)
Virus typeRNA
Virus familyReoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with radiation, 3 Gy (synergism)
Immune gene induction in virus genomeNo
Source of cell lineProf. Richard Marais lab
Origin of cell lineHuman cutaneous melanoma cell line
Cell linePMWK
Concentration of cell line1
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration1 MOI
In-vitro result12% cancer cell viability (calculated as relative to non-infected group)
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionDown-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3
Immunogenic effectNA
Clinical trialNA
PMID27384486