| Primary information |
|---|
| OV_ID | OV_667 |
| Virus Name | Reovirus |
| Strain | RT3D (Reolysin) |
| Virus type | RNA |
| Virus family | Reoviridae |
| Modification in virus genome | None |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Viral strain in combination with radiation, 5 Gy (antagonism) |
| Immune gene induction in virus genome | No |
| Source of cell line | Prof. Richard Marais lab |
| Origin of cell line | Human cutaneous melanoma cell line |
| Cell line | WM1791c |
| Concentration of cell line | 1 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 0.5 MOI |
| In-vitro result | 91% cancer cell viability (calculated as relative to non-infected group) |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3 |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27384486 |