Browse Epitopes |
This module is created to browse the epitopes predicted from vaccine candidates of all mycobacterial strains. This epitopes were predicted by creating 9mer overlapping peptides from the vaccine candidates from each mycobacterial species. We used a prediction pipeline for predicting the epitopes. Currently, you are browsing B cell epitopes from our compiled results. Here, the first column represent the unique Mtbeveb ID for each peptide sequences. The ID and peptide sequence is hyperlinked to epitope card. The next column contains Gene ID, which is hyperlinked to antigen card. The next column displays the detail of protien from NCBI notation. The fourth column presents the position of the peptide in that protein.
This pipeline have the package for predicting linear B cell epitopes using LBtope, promiscous binder of MHC class I (Propred1) and MHC class II (Propred), CTL epitope (CTLpred), interferon-gamma inducing peptides (IFNepitope) and Interleukine 4 inducing peptides (IL4pred). The peptides can sorted at any header.
The last five columns present the fields related to MHC class II prediction using Propred followed by prediction of interferon-gamma inducing peptides. The sixth column tells us the MHC class II alleles to which peptide is binding. The seventh column counts the number of MHC class II alleles for that peptide.
The eighth column depicts the prediction result of IFNepitope server with ninth column present the alogirithm of IFNepitope program. The last column display the score of peptides from IFNepitope server.
Total number of predicted 9mer peptides are 108182 (corresponding to browse type th1)
ID | gene ID | Protein Detail | Position | Sequence (9mer) | MHC class II Alleles | MHC class II alleles (count) | IFN-gamma inducing algorithm | IFN-gamma inducing Score |
---|---|---|---|---|---|---|---|---|
VIR000033 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 33 | LFRRVVSWG | DRB1_0402, DRB1_0801, DRB1_0802, DRB1_0804, DRB1_0806, DRB1_0813, DRB1_0817 | 7 | SVM | 0.03 |
VIR000040 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 40 | WGRSSNVFL | DRB1_0101, DRB1_0401, DRB1_0421, DRB1_0426, DRB1_0701, DRB1_0703 | 6 | SVM | 0.42 |
VIR000055 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 55 | YLDVGSHPE | DRB1_0405 | 1 | SVM | 0.06 |
VIR000072 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 72 | LVQLVTHDR | DRB1_0102, DRB1_0401, DRB1_0402, DRB1_0404, DRB1_0405, DRB1_0408, DRB1_0410, DRB1_0421, DRB1_0423, DRB1_0426, DRB1_0804, DRB1_1101, DRB1_1102, DRB1_1104, DRB1_1106, DRB1_1114, DRB1_1120, DRB1_1121, DRB1_1128, DRB1_1301, DRB1_1302, DRB1_1304, DRB1_1305, DRB1_1307, DRB1_1311, DRB1_1322, DRB1_1323, DRB1_1327, DRB1_1328, DRB5_0101, DRB5_0105 | 31 | SVM | 0.13 |
VIR000120 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 120 | YGCHENYLI | DRB1_0402, DRB1_0421, DRB1_0701, DRB1_0703, DRB1_1502 | 5 | SVM | 0.11 |
VIR000126 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 126 | YLIVRAGEF | DRB1_0101, DRB1_0309, DRB1_0701, DRB1_0703, DRB1_0801, DRB1_0802, DRB1_1101, DRB1_1128, DRB1_1305, DRB1_1307, DRB1_1321, DRB5_0101, DRB5_0105 | 13 | SVM | 0.70 |
VIR000127 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 127 | LIVRAGEFS | DRB1_0813 | 1 | SVM | 0.42 |
VIR000128 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 128 | IVRAGEFSR | DRB5_0101, DRB5_0105 | 2 | SVM | 0.34 |
VIR000166 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 166 | YCLSQRAEH | DRB1_0305, DRB1_0801, DRB1_0802, DRB1_1101, DRB1_1114, DRB1_1307, DRB1_1321, DRB1_1323 | 8 | SVM | 0.10 |
VIR000208 | 169629269 | YP 001702918.1 hypotheticalproteinMAB 2183[MycobacteriumabscessusATCC19977] | 208 | VIVGDSNMA | DRB1_0306, DRB1_0307, DRB1_0308, DRB1_0311, DRB1_0402 | 5 | SVM | 0.00 |
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