| 1037 | Colutellin A | VISIIPV | 7 | L | None | None | None | Cyclic | Natural | Endophytic fungus Colletotrichum dematium | Inhibit IL-2 production by activated CD4+ T-cells | Inhibiting the calcineurin pathway | Both | Peripheral blood mononuclear cells (PBMCs) | 167.3±0.38 nM for CD4+ T cell activation of IL-2 production | C57/B6 mice | MIC assay, Immunosuppression and toxicity test | MIC of 3.6 mg/ml (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum. | NA | 18599825 | 2008 |
| 1045 | Cyclolinopeptide A (CLA) | VPPFFLIIL | 9 | L | None | None | None | Cyclic | Natural | isolated from linseed oil | Cyclophilin A, IL-1α, IL-2 | it binds to cyclophilin A and inhibits the action of Interleukin-1-alpha and Interleukin-2 | Both | SRBC (Sheep red blood cells) | dose combinations: 0.1 mg/ml of CLA and 0.25 mM of MTX exhibited suppressive, synergistic action | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | Methotrexate (MTX) | 21839548 | 2011 |
| 1046 | CLA analogue1 | LVPPFFLII | 9 | L | None | None | Ethylene bridge (-CH2-CH2-) between phenylalanine nitrogens | Cyclic | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1047 | CLA analogue2 | LVPPffLII | 9 | Mix | None | None | Ethylene bridge (-CH2-CH2-) between phenylalanine nitrogens | Cyclic | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1048 | CLA analogue3 | LVPPFFLII | 9 | L | None | None | Ethylene bridge (-CH2-CH2-) between phenylalanine nitrogens | Linear | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1049 | CLA analogue4 | LVPPffLII | 9 | Mix | None | None | Ethylene bridge (-CH2-CH2-) between phenylalanine nitrogens | Linear | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1050 | CLA analogue5 | LVPPFFLII | 9 | L | None | None | None | Linear | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1064 | Antamanide | VPPAFFPPFF | 10 | L | None | None | None | Cyclic | Natural | Isolated from the poisonous mushroom Amanita phalloides | Peptidyl-prolyl cis-trans isomerase CyP-D | Inhibit mitochondrial permeability transition pore | Both | HeLa Cells | NA | C57BL/6 mice | Cell Viability assay, Ca2+ retention capacity assay | NA | NA | 21297983 | 2011 |
| 1065 | Cyclolinopeptide A (CLA) | VPPFFLIIL | 9 | L | None | None | None | Cyclic | Synthetic | NA | NA | Inhibition of the action of interleukin-1 and interleukin-2 | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1066 | Antamanide | VPPAFFPPFF | 10 | L | None | None | None | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1067 | Cycloamanide A (CyA A) | VFFAGP | 6 | L | None | None | None | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1068 | [D-Phe3]CyA A | VFfAGP | 6 | Mix | None | None | None | Cyclic | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1069 | Cycloamanide B (CyA B) | FFFPIPS | 7 | L | None | None | None | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1070 | [D-Ser]CyA B | FFFPIPs | 7 | Mix | None | None | None | Cyclic | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1071 | Cycloamanide C | LPMLGFLV | 8 | L | None | None | R and S sulfoxide on methionine | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1072 | Cycloamanide D | LPMLGFLP | 8 | L | None | None | R and S sulfoxide on methionine | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1073 | Retro-[D-Phe3]CyA A | fFVPGA | 6 | Mix | None | None | None | Cyclic | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1074 | Retro-[D-Phe3]CyA A | fFVPGA | 6 | Mix | None | None | None | Linear | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1086 | Ac1-9 | ASQKRPSQR | 9 | L | Acetylation | None | None | Linear | Protein Derived | From myelin basic protein | IL-10 and IL-2 | peptide-induced regulatory cells suppress the response of naive T cells and leads to the generation of IL-10-secreting regulatory cells | Both | purified T cells | NA | Tg4 transgenic mouse | CD4 T cell Proliferation assays, Cytokine protein levels assays | NA | NA | 12538682 | 2003 |
| 1087 | MHC-binding analog (Ac1-9[4Y]) | ASQYRPSQR | 9 | L | Acetylation | None | None | Linear | Synthetic | Analog of Ac1-9 | IL-10 and IL-3 | peptide-induced regulatory cells suppress the response of naive T cells and leads to the generation of IL-10-secreting regulatory cells | Both | purified T cells | NA | Tg4 transgenic mouse | CD4 T cell Proliferation assays, Cytokine protein levels assays | NA | NA | 12538682 | 2003 |
| 1092 | CKS-17 | LQNRRGLD | 8 | L | None | None | None | Linear | Protein Derived | murine leukemia virus pl5E TM protein | NA | Unknown | In vitro | Normal brain tissue, kidney, lymphocytes, cultured embryonic lung cells, rhabdomyosarcoma cell line | NA | NA | Evolutionary conservation and PCR-based assay | NA | NA | 8419641 | 1992 |
| 1097 | HLA-B2702 (75-84) | WIEQEGPEYW | 10 | L | None | None | None | Linear | Protein Derived | MHC molecule | NA | NA | Both | NA | NA | LEW rat | T cell assay | NA | NA | 8573307 | 1995 |
| 1098 | HLA-B38 (75-84) | WIEQEGPEYW | 10 | L | None | None | None | Linear | Protein Derived | MHC molecule | NA | NA | Both | NA | NA | LEW rat | Graft transplation assay | NA | NA | 8573307 | 1995 |
| 1105 | Heme oxygenase-1 (HO-1) Peptide D2702.75-84 | RENLRIALRY | 10 | L | None | None | None | Linear | Protein Derived | α1-helix of HLA-B2702 | HSC70 and HSP70 | Not Available | Both | Human T cell leukemia cell line Jurkat (clone E6-1) and a mouse lymphoma cell line Yac-1 | NA | Male, 7-8-week-old CBA/J (H-2k) and C57BL/6/J (H-2b) mice | NA | NA | NA | 9446574 | 1997 |
| 1106 | Heme oxygenase-1 (HO-1) Peptide D2702.75-84(E-V) | rvnlrialry | 10 | D | None | None | None | Linear | Protein Derived | α1-helix of HLA-B2703 | NA | Not Available | Both | Human T cell leukemia cell line Jurkat (clone E6-1) and a mouse lymphoma cell line Yac-2 | NA | C57Bl/6 and CBA mice | NA | NA | NA | 9446574 | 1997 |
| 1108 | Core peptide (CP) | GLRILLLKV | 9 | L | None | None | None | Linear | Synthetic | NA | NA | Not Available | In vivo | NA | NA | Female Wistar rat | NA | NA | NA | 245138095 | 2014 |
| 1111 | Collutellin A | VISIIPV | 7 | L | None | None | None | Cyclic | Natural | Colletotrichum dematium (fungus) | IL-2 | Reduces IL2 production | In vitro | C57/B6 mice spleen cells | 167.3+/-0.38 nM | C57/B6 mice | NA | NA | NA | 24333193 | 2014 |
| 1112 | Antamides | VPPAFFPPFF | 10 | L | None | None | None | Cyclic | Natural | Amanita phalloides spp. (fungus) | NA | Inhibition of mitochondrial permeability transition pores | Both | fibroblasts | NA | C57BL/6 mice | NA | NA | NA | 24333193 | 2014 |
| 1122 | Curcacycline B (Orbitide) | LGSPILLGI | 9 | L | None | None | None | Cyclic | Natural | Jatropha curcas (plant) | PPIase | PPIase inhbitior | In vitro | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1124 | Cyclolinopeptide A/B (Orbitide) | IMLIPPFFV | 9 | L | None | None | None | Cyclic | Natural | Linum usitatissimum (plant) | Calcineurin | CYPA binding and calcineurin inhibition | In vivo | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1131 | core peptide (CP) | GLRILLLKV | 9 | L | None | None | None | Linear | Protein Derived | T-cell antigen receptor alpha-chain transmembrane region | IL-2 | Inhibits IL-2 production | In vitro | Alanine scan, LK antigen-presenting cells | NA | NA | Antigen presentation assay, CTLL assay | NA | NA | 23066996 | 2013 |
| 1136 | Nonapeptide of HLA-DR | VPRSGEVYT | 9 | L | None | None | None | Linear | Synthetic | NA | NA | NA | Both | Spleen Cells | NA | CBA, BALB/c and C57BL, 8-12 weeks old mice | Plaque-forming cells (PFC) and delayed type hypersensitivity (DTH) assay | NA | NA | 15063002 | 2004 |
| 1143 | HLA B-2702 (2702.75-84) | RENLRIALRY | 10 | L | None | None | None | Linear | Natural | NA | T-cell | Inhibits the differentiation of cytotoxic T cells and also decrease natural killer (NK) cell-mediated cytotoxicity | In vivo | NA | NA | Eight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')rats | Graft transplation assay | NA | NA | 10666482 | 2000 |
| 1144 | B-0701 (07.75-84) | RESLRNLRGY | 10 | L | None | None | None | Linear | Natural | NA | T-cell | Inhibits the differentiation of cytotoxic T cells and also decrease natural killer (NK) cell-mediated cytotoxicity | In vivo | NA | 200 micromolar | Eight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')rats | Graft transplation assay | NA | NA | 10666482 | 2000 |
| 1146 | HLA-B2702 (2702.75-84) | RENLRIALRY | 10 | L | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 1.0±0.4 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1147 | 2702.84-75 | YRLAIRLNER | 10 | L | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 1.2 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1148 | D2702.75-84 | renrialry | 9 | D | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.15±0.05 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1149 | D2702.84-75 | yrlairlner | 10 | D | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.3 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1150 | P2 | RVNLRIALRY | 10 | L | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.15±0.08 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1151 | RP2 | YRLAIRLNVR | 10 | L | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.2 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1152 | D2 | rvnlrialry | 10 | D | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.17±0.09 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1153 | RD2 | yrlairlnvr | 10 | D | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.3 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1154 | P15 | NLRIALAYYW | 10 | L | None | None | None | Linear | Natural | Heavy chain of HLA class I | NA | Not Available | Both | In silico screening (MD simulations) | 0.2 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1155 | RDP1257 | RLLLRLLLGY | 10 | L | None | None | None | Linear | Natural | HLA/MHC molecule | NA | Not Available | Both | In silico screening (MD simulations) | 1.4±0.2 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1156 | RDP1259 | RVLLRLLLGY | 10 | L | None | None | None | Linear | Natural | HLA/MHC molecule | NA | Not Available | Both | In silico screening (MD simulations) | 1.4±0.15 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1157 | RDP1271 | RWLLRLLLGY | 10 | L | None | None | None | Linear | Natural | HLA/MHC molecule | NA | Not Available | Both | In silico screening (MD simulations) | 1.4±0.3 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1158 | RDP1277 | RYLLALLLGY | 10 | L | None | None | None | Linear | Natural | HLA/MHC molecule | NA | Not Available | Both | In silico screening (MD simulations) | 1.4±0.2 micromolar | CBA and C57BI/6 mice | Graft transplation assay | NA | NA | 9702773 | 1998 |
| 1168 | HIV-env 854-863 | IRQGLERILL | 10 | L | None | None | None | Linear | Synthetic | NA | NA | Not Available | In vitro | Human sera | NA | NA | NA | NA | NA | 2455899 | 1988 |
| 1202 | A1HS1 | II-Sta-PYVPL | 8 | L | None | None | Sta = (3S, 4S) -4- amino-3-hydroxy-6-methyl-heptanoic acid(C8H17NO3) | Cyclic | Synthetic | NA | Lymphocytes, Macrophages | Influence of phagocytic function of macrophages, and the retarding effect of the proliferation of Lymphocytes | Both | Spleen Lymphocyte | NA | BALB / C mice | Delayed-type hypersensitivity (DTH) test, Lymphocyte Proliferation test, MTT | NA | | CN 101289499 B | 2010 |
| 1203 | A3HS1 | IIPPYV-Sta-L | 8 | L | None | None | Sta = Statine | Cyclic | Synthetic | NA | Lymphocytes, Macrophages | Influence of phagocytic function of macrophages, and the retarding effect of the proliferation of Lymphocytes | Both | Spleen Lymphocyte | NA | BALB / C mice | Delayed-type hypersensitivity (DTH) test, Lymphocyte Proliferation test, MTT | NA | | CN 101289498 B | 2010 |
