Browse result page of TopicalPdb

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The total number entries retrieved from this search are

ID	Sequence	Name	Nature of peptide or cargo	Assay	Tissue permeability	Tissue Sample	PUBMED ID
ID1002	SequenceAAPV	NameAAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=0.46 μg/cm2/h, Permeability coefficient=1.50×10−4Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1003	SequenceAAPV	NameC6(D)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=2.29 μg/cm2/h, Permeability coefficient=7.6×10−4 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1004	SequenceAAPV	NameC6(L)-Laa- AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=0.50 μg/cm2/h, Permeability coefficient=1.6×10−4 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1005	SequenceAAPV	NameC8(D,L)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=10.08 μg/cm2/h, Permeability coefficient= 3.3×10−3 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1006	SequenceAAPV	NameC8(D)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=7.42 μg/cm2/h, Permeability coefficient=1.90×10−2 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1007	SequenceAAPV	NameC8(L)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=1.37 μg/cm2/h, Permeability coefficient=4.50×10−4 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1008	SequenceAAPV	NameC10(D,L)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=8.92 μg/cm2/h, Permeability coefficient=2.9×10−3 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1010	SequenceGKRR	NameR4 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1011	SequenceGKRR	NameR4 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 43.74 ± 4.15 , Q48(mg) 2064.72 ± 100.05 Drug content in skin (mg/cm2) 180 ± 8.23	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1012	SequenceGKRR	NameR4 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1028	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1029	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1030	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>1% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1031	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1032	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1033	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>1.5% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1034	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~2% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1035	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<4% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1036	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~0.5% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1037	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<1% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1038	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>8% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1039	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<4% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1040	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<18% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1041	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1042	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>8% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1043	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1044	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~6% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1045	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~1.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1046	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1047	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1048	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~2% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1049	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~7% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1050	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1051	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability2% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1052	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~11% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1053	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~9% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1054	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1055	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~10% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1056	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~7% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1057	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~5% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1058	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~12% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1059	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>4% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1060	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~4% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1061	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>36% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1062	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>26% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1063	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~26% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1064	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability25% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1065	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability20% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1066	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~20% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1067	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~26% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441