Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2408NA

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Respiratory syncytial virus (virus) NANANANAsignificantly increased the risk of RSV bronchiolitisrs2228570*VDRVitamin D receptior (VDR)HumanNANANANANANANA292536102017NA
PRRID_2408NA

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Respiratory syncytial virus (virus) NANANANAsignificantly increased the risk of RSV bronchiolitisrs2228570*VDRVitamin D receptior (VDR)HumanNANANANANANANA292536102017NA
PRRID_2409NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsrs7656411*Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2409NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsrs7656411*Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2423NA

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pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2423NA

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pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2436NA

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Enterovirus 71 (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2436NA

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Enterovirus 71 (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2451NA

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Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2451NA

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Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2452NA

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Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2452NA

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Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2466NA

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HIRRV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusGills and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2466NA

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HIRRV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusGills and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2469NA

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Grass carp reovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantScToll-like receptor 2 (TLR2)2Toll-like receptor (TLR)Squaliobarbus curriculushead kidney and spleen19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain.NANANANF-κB activation that up-regulates secretion of proinflammatory cytokines.qRT-PCR284424182017NA
PRRID_2469NA

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Grass carp reovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantScToll-like receptor 2 (TLR2)2Toll-like receptor (TLR)Squaliobarbus curriculushead kidney and spleen19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain.NANANANF-κB activation that up-regulates secretion of proinflammatory cytokines.qRT-PCR284424182017NA
PRRID_2471NA

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white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPcToll4Toll-like receptor (TLR)Procambarus clarkiiAll tested tissueA single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain.NANANAregulates the expressions of AMPs against WSSVqRT-PCR282130412017NA
PRRID_2471NA

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white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPcToll4Toll-like receptor (TLR)Procambarus clarkiiAll tested tissueA single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain.NANANAregulates the expressions of AMPs against WSSVqRT-PCR282130412017NA
PRRID_2533pathogen ssRNA

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flu virus, SeV and bacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2533pathogen ssRNA

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flu virus, SeV and bacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2580R837

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2580R837

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2581R848

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2581R848

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2582R848

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2582R848

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2591RNA

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Type B coxsackieviruses (CVBs) (others)NANANucleic AcidNaturalmyocarditis and acute pancreatitisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Micedendritic cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905NANA289730472017Pubchem_assay
PRRID_2591RNA

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Type B coxsackieviruses (CVBs) (others)NANANucleic AcidNaturalmyocarditis and acute pancreatitisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Micedendritic cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905NANA289730472017Pubchem_assay
PRRID_2614short dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANAPattern-associated molecular patterns (PAMPs)NaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2614short dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANAPattern-associated molecular patterns (PAMPs)NaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2618single-stranded RNA

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exogenous viruses (virus)NANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humancellular endosomal compartments,Leucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2618single-stranded RNA

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exogenous viruses (virus)NANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humancellular endosomal compartments,Leucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2623single-stranded RNA

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Respiratory syncytial virus (virus) NANANucleic AcidNaturalRespiratory syncytial virus infection, activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2623single-stranded RNA

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Respiratory syncytial virus (virus) NANANucleic AcidNaturalRespiratory syncytial virus infection, activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2624single-stranded RNA

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Vesicular stomatitis (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2624single-stranded RNA

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Vesicular stomatitis (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2625single-stranded RNA

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Parainfluenza (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2625single-stranded RNA

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Parainfluenza (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2626single-stranded RNA

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Influenza A (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2626single-stranded RNA

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Influenza A (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2627single-stranded RNA

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANANucleic AcidNaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2627single-stranded RNA

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANANucleic AcidNaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2628single-stranded RNA

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANANucleic AcidNaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2628single-stranded RNA

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANANucleic AcidNaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2638synthetic dsRNA

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2638synthetic dsRNA

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2688Viral effector epitope

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Tospovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of SW-5bSW-5bNOD-like receptor (NLR)Solanum LycopersicumNALRR domainNANANAConfers broad spectrum against American-type tospoviruses by recognizing a conserved 21-amino acid peptide region within viral movement protein NSm (NSm21)NA288146462017NA
PRRID_2688Viral effector epitope

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Tospovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of SW-5bSW-5bNOD-like receptor (NLR)Solanum LycopersicumNALRR domainNANANAConfers broad spectrum against American-type tospoviruses by recognizing a conserved 21-amino acid peptide region within viral movement protein NSm (NSm21)NA288146462017NA
PRRID_2689Viral RNA

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RSV, IAV, and HCMV (virus)NANANucleic AcidNaturalLikely tetramerization into washer- locker structureNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanCytoplasm. Macrophages, monocytes, Paneth cells, DCsNAQ9HC29.fastaQ9HC291040NANA283749032017Pubchem_assay
PRRID_2689Viral RNA

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RSV, IAV, and HCMV (virus)NANANucleic AcidNaturalLikely tetramerization into washer- locker structureNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanCytoplasm. Macrophages, monocytes, Paneth cells, DCsNAQ9HC29.fastaQ9HC291040NANA283749032017Pubchem_assay