Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1898A phenol-soluble modulin

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NANANANANaturalCytokine IL-10, IL-6 and IL-12) secretion in DCs and macrophages to induce immunological tolerance through secretion og TGF- βToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NAHeLa cell lineLeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_1898A phenol-soluble modulin

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NANANANANaturalCytokine IL-10, IL-6 and IL-12) secretion in DCs and macrophages to induce immunological tolerance through secretion og TGF- βToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NAHeLa cell lineLeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_1903Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Activate NF-KBNA280491422017Pubchem_assay
PRRID_1903Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Activate NF-KBNA280491422017Pubchem_assay
PRRID_1906Aeromonas hydrophila

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalPathogenic infectionCcToll-like receptor (TLR18)Toll-like receptor (TLR)Common Carp (Cyprinus carpio L)head kidney, foregut, hindgut and skin.LRR motifs, a transmembrane region and a TIR domainNANANANAReal-time PCR291113942017NA
PRRID_1906Aeromonas hydrophila

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalPathogenic infectionCcToll-like receptor (TLR18)Toll-like receptor (TLR)Common Carp (Cyprinus carpio L)head kidney, foregut, hindgut and skin.LRR motifs, a transmembrane region and a TIR domainNANANANAReal-time PCR291113942017NA
PRRID_1907Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_1907Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_1909Aggrecan

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Proteoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1909Aggrecan

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Proteoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1916analog poly I:C

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1916analog poly I:C

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1949Bacterial flagella

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495Fatty acid NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA292639322017Pubchem_assay
PRRID_1949Bacterial flagella

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495Fatty acid NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA292639322017Pubchem_assay
PRRID_1950Bacterial lipoprotein

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BacteriaNANANANaturalEnhance antigen uptake and simultaneously increases cytokine production ,IL- production, DC maturation, cell activation, induce NFκB activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_1950Bacterial lipoprotein

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BacteriaNANANANaturalEnhance antigen uptake and simultaneously increases cytokine production ,IL- production, DC maturation, cell activation, induce NFκB activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_1951Bacterial LPS

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BacteriaNANAGlycoproteinNaturalpathogenic infectionToll-like receptor 4 /MD2 (TLR4/MD2)Toll-like receptor (TLR)NAmembrane-associatedTIR domainsNANANANANA281150372017NA
PRRID_1951Bacterial LPS

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BacteriaNANAGlycoproteinNaturalpathogenic infectionToll-like receptor 4 /MD2 (TLR4/MD2)Toll-like receptor (TLR)NAmembrane-associatedTIR domainsNANANANANA281150372017NA
PRRID_1953Bacterial RNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)Epinephelus coioidesendoplasmic reticulum and early endosomeextracellular LRR region, a transmembrane domain and an intracellular TIR domainNANANANANA293053352017NA
PRRID_1953Bacterial RNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)Epinephelus coioidesendoplasmic reticulum and early endosomeextracellular LRR region, a transmembrane domain and an intracellular TIR domainNANANANANA293053352017NA
PRRID_1957Biglycan

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Proteoglycan (others)MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1957Biglycan

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Proteoglycan (others)MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1958Biglycan

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Proteoglycan (others)MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1958Biglycan

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Proteoglycan (others)MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1960Biglycan

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NAMWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalInduce the secretion of TNF-α, MIP-2 and IL-1β by murine macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA289610192017Pubchem_assay
PRRID_1960Biglycan

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NAMWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalInduce the secretion of TNF-α, MIP-2 and IL-1β by murine macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA289610192017Pubchem_assay
PRRID_1961Biglycan

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NAMWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalInduce the secretion of TNF-α, MIP-2 and IL-1β by murine macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesQ9QUK6Q9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_1961Biglycan

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NAMWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalInduce the secretion of TNF-α, MIP-2 and IL-1β by murine macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesQ9QUK6Q9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_1964Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNANANaturalInduce production of inflammatory cytokinesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290283692017Pubchem_assay
PRRID_1964Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNANANaturalInduce production of inflammatory cytokinesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290283692017Pubchem_assay
PRRID_1967Capsule polysaccharide

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NANANANANaturalImmune activation, in ammationToll-like receptor (TLR1/2 (triacylated lipoproteins)Toll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_1967Capsule polysaccharide

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NANANANANaturalImmune activation, in ammationToll-like receptor (TLR1/2 (triacylated lipoproteins)Toll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_1968CBLB502

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Salmonella flagellin (Bacteria)NANANANaturaldirect radioprotective effect in vitro via anti-apoptosis and promotes cell cycle recoveryToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHEK293-N-T cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAReal-time PCR284070322017Pubchem_assay
PRRID_1968CBLB502

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Salmonella flagellin (Bacteria)NANANANaturaldirect radioprotective effect in vitro via anti-apoptosis and promotes cell cycle recoveryToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHEK293-N-T cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAReal-time PCR284070322017Pubchem_assay
PRRID_1975Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR) HumanLungs and gutTIR domainO60603.fastaO60603784Activate immune cells to induce cytokine productionNA282515812017Pubchem_assay
PRRID_1975Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR) HumanLungs and gutTIR domainO60603.fastaO60603784Activate immune cells to induce cytokine productionNA282515812017Pubchem_assay
PRRID_1977Chlyamydia components

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Chlamydia(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulant and cause chlaymydia infections.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAleucine-rich repeat (LRR), hydrophobic transmembrane and cytoplasmic Toll/interleukin-1 receptor (TIR) domainsNANANApromote transcription from pro-inflammatory cytokines including IL-1 and IL-12NA285040912017NA
PRRID_1977Chlyamydia components

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Chlamydia(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulant and cause chlaymydia infections.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAleucine-rich repeat (LRR), hydrophobic transmembrane and cytoplasmic Toll/interleukin-1 receptor (TIR) domainsNANANApromote transcription from pro-inflammatory cytokines including IL-1 and IL-12NA285040912017NA
PRRID_1979Chromatin-IgG complexes

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NANANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanlymphoid tissueLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_1979Chromatin-IgG complexes

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NANANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanlymphoid tissueLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_1980Chromogranin A

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)Naturalactivate microglial cellsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAActivate NF-KBNA280491422017NA
PRRID_1980Chromogranin A

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)Naturalactivate microglial cellsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAActivate NF-KBNA280491422017NA
PRRID_1983CL075

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)SyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1983CL075

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)SyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1984CL097

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)NNANucleic AcidSyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1984CL097

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)NNANucleic AcidSyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1985CL097

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)NNANucleic AcidSyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1985CL097

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)NNANucleic AcidSyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1988CpG-ODN

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BacteriaNANANucleic AcidSyntheticOral carcinogenesisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032interferon-β production and activation of caspases 3 and 9NA289828472017Pubchem_assay
PRRID_1988CpG-ODN

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BacteriaNANANucleic AcidSyntheticOral carcinogenesisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032interferon-β production and activation of caspases 3 and 9NA289828472017Pubchem_assay
PRRID_1995Decorin

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Proteoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1995Decorin

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Proteoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1996Decorin

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Proteoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1996Decorin

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Proteoglycan (others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1997diacylated and triacylated lipopeptides

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NANANANANaturalNAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNANAQ15399.fastaQ15399786NANA290662552017Pubchem_assay
PRRID_1997diacylated and triacylated lipopeptides

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NANANANANaturalNAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNANAQ15399.fastaQ15399786NANA290662552017Pubchem_assay
PRRID_1998Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_1998Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_1999Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA292639322017Pubchem_assay
PRRID_1999Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA292639322017Pubchem_assay
PRRID_2001DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154Activate NF-KBNA280491422017Pubchem_assay
PRRID_2001DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154Activate NF-KBNA280491422017Pubchem_assay
PRRID_2004DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanDendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154NANA289610192017Pubchem_assay
PRRID_2004DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanDendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154NANA289610192017Pubchem_assay
PRRID_2005DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA289610192017Pubchem_assay
PRRID_2005DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA289610192017Pubchem_assay
PRRID_2006DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289610192017Pubchem_assay
PRRID_2006DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289610192017Pubchem_assay
PRRID_2008dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNANAO15455.fastaO15455904NANA290662552017Pubchem_assay
PRRID_2008dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNANAO15455.fastaO15455904NANA290662552017Pubchem_assay
PRRID_2010dsRNA

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NANANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2010dsRNA

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NANANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2013dsRNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2013dsRNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2014dsRNA-polyinosinic- polycytidilic acid

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BacteriaNANANASyntheticOral carcinogenesisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904promote tumour growth through inflammation dependent mechanism in epithelial cells.NA289828472017Pubchem_assay
PRRID_2014dsRNA-polyinosinic- polycytidilic acid

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BacteriaNANANASyntheticOral carcinogenesisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904promote tumour growth through inflammation dependent mechanism in epithelial cells.NA289828472017Pubchem_assay
PRRID_2018endogenous nucleic acids

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Host (Endogenous) (others)NANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2018endogenous nucleic acids

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Host (Endogenous) (others)NANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2019endogenous nucleic acids

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Host (Endogenous) (others)NANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2019endogenous nucleic acids

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Host (Endogenous) (others)NANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2020Envelope F protein

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NANANANANaturalinduce proinflammatory cytokine production through NF-KB signaling, Activates the innate immune response by driving NF-κB-mediated cytokine expression, Activate macrophages through MyD88 and TRAF6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHuman PBMCsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290283692017Pubchem_assay
PRRID_2020Envelope F protein

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NANANANANaturalinduce proinflammatory cytokine production through NF-KB signaling, Activates the innate immune response by driving NF-κB-mediated cytokine expression, Activate macrophages through MyD88 and TRAF6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHuman PBMCsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290283692017Pubchem_assay
PRRID_2025fHbp

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NANANANANaturalMarcophages Adjuvant activity in fHbp vaccineToll-like receptor (TLR1/2 (triacylated lipoproteins)Toll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2025fHbp

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NANANANANaturalMarcophages Adjuvant activity in fHbp vaccineToll-like receptor (TLR1/2 (triacylated lipoproteins)Toll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2026Fibrinogen

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ECM glycoprotein(others)MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG211Damage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2026Fibrinogen

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ECM glycoprotein(others)MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG211Damage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2027Fibrinogen

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Host (Endogenous) (others)MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG211Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMouse podocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2027Fibrinogen

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Host (Endogenous) (others)MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG211Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMouse podocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2028Fibronectin

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ECM glycoprotein(others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANAFN-derived domainsNANANANANA292901392017NA
PRRID_2028Fibronectin

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ECM glycoprotein(others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANAFN-derived domainsNANANANANA292901392017NA
PRRID_2029Fibronectin

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ECM glycoprotein(others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAFN-derived domainsNANANANANA292901392017NA
PRRID_2029Fibronectin

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ECM glycoprotein(others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAFN-derived domainsNANANANANA292901392017NA
PRRID_2030Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the production of TNF-α, IL-6 and IL-1β in mast cells.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)mast cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2030Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the production of TNF-α, IL-6 and IL-1β in mast cells.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)mast cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2031Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the production of TNF-α and IL-6 in murine in splenocytes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)SplenocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2031Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the production of TNF-α and IL-6 in murine in splenocytes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)SplenocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2032Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the biosynthesis of leukotriene B4 in human neutrophils and monocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNeutrophils and monocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2032Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the biosynthesis of leukotriene B4 in human neutrophils and monocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNeutrophils and monocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2033FLA-ST Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495NANaturalanti- inflammatory activityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA291137972017Pubchem_assay
PRRID_2033FLA-ST Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495NANaturalanti- inflammatory activityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA291137972017Pubchem_assay